Lab Research:
Our lab focuses on ultrasound transducer fabrication, focused ultrasound (HIFU/LIPUS) for therapeutic applications, AI-enabled ultrasound analysis, ultrasound neuromodulation, acoustic tweezers for precision manipulation, and non-invasive brain stimulation through sonogenetics, advancing diagnostics and therapy at the intersection of ultrasound and life sciences.
1. Ultrasound Transducer Fabrication:
Our lab develops ultrasound transducers operating between 5 and 500 MHz to enhance imaging and therapeutic precision. We apply advanced design and fabrication methods to enable real-time imaging, treatment, and cellular analysis, expanding their biomedical applications. Our goal is to advance ultrasound technology for improved healthcare outcomes.
2. Focused Ultrasound (HIFU & LIPUS):
High-Intensity Focused Ultrasound (HIFU) and Low-Intensity Pulsed Ultrasound (LIPUS) play key roles in non-invasive medical procedures. Our lab refines these technologies for both in vivo and in vitro applications, focusing on reducing side effects, improving precision, and enhancing therapeutic outcomes in areas such as tumor ablation, drug delivery, and neurological disorders. By advancing these ultrasound-based therapies, we aim to improve the effectiveness of minimally invasive treatments.
HIFU and LOFU
Ultrasound-guided HIFU therapy
HIFU treatment
Sperm stimulation
C. elegans stimulation
Plankton manipulation
3. Acoustic Tweezers:
Acoustic tweezers use sound waves to manipulate cells and microparticles. Our research focuses on improving their precision and efficiency in cell analysis, cell classification, drug delivery, and tissue engineering. We develop methods to enhance their controllability and adaptability for broader biomedical and biotechnological applications.
RBC manipulation
Single RBC trapping
Cell deformation
4. AI-enabled Ultrasound
Our lab integrates AI with ultrasound analysis to enable rapid, automated, and precise characterization. We develop algorithms that advance disease diagnosis, drug development, and biotechnology research. This approach enhances our ability to understand and control biological processes for scientific and medical applications.
AI-enabled Ultrasound (Diabetes)
AI-enabled Ultrasound (Water & Pipe)
AI-enabled Ultrasound (Plankton)
AI-enabled Ultrasound (Particle)
AI-enabled Ultrasound (RBC)
5. Cell Therapy & Cell Mechanics:
Our research investigates the mechanical properties of cells and their responses to therapeutic interventions. This knowledge supports the development of advanced cell-based therapies, including nanomedicine and cancer treatment. By studying how cells respond to different mechanical conditions, we aim to improve the design and delivery of cell therapies for greater efficacy and safety.
Cancer Cell Therapy
Cell deformation
RBC mechanics
6. Nanoparticle Fabrication and Applications:
7. Brain stimulation:
8. Acoustic Haptics & Acoustic Levitation:
Acoustic Haptics & Levitation: Using sound waves to generate tactile sensations and levitate objects, enhancing VR haptics and advancing material handling technologies. This research pushes the boundaries of sensory perception and practical applications.
Acoustic Haptics with VR
Acoustic Haptics
Acoustic Levitation
Acoustic Hand
Acoustic Tong