Publications

# Denotes equal contribution

* Denotes co-corresponding authors

60. Jang S, Yoon S, Yang H, Choi N, Han SH, Kim LK, Kim HP, Park JH, Lee D, Yoo KH (2025) Coordinated gene expression within sustained STAT3-associated chromatin conformations contributes to hepatocellular carcinoma progression. Cancer Commun (Lond) 45(10), 1309-1333.

59. Cho M#, Kim SM#, Lee J, Kwon OC, Woo W, Lee E, Park HJ, Lee Y, Dho SH, Kim TK, Park MC, Flavell RA*, Kim LK* (2025) Targeting eRNA-Producing Super-Enhancers Regulates TNFα Expression and Mitigates Chronic Inflammation in Mice and Patient-Derived Immune Cells. Adv Sci (Weinh) 12(39), e05214.

58. Hong S, Kim SP, Kim S, Kang SK, Jung S, Oh Y, Choi SH, Lee SB, Cha H, Kim J, Bae J, Park J, Kim K, Choi CG, Park SJ, Kim DH, Kim LK, Seong JK, Lee H (2025) Alterations in mitochondrial base editors enhance targeted editing efficiency for mouse model generation. Mol Ther Nucleic Acids 36(3), 102678.

57. Dho SH#, Cho M#, Woo W#, Jeong S, Kim LK (2025) Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyond. Exp Mol Med 57(6), 1121-1132.

56. Zhang K, Kim SM, Kwon HK, Kim SH, Kim TG, Sun Z, Kim HL, Tyo A, Kim JH, Kim RW, Kim JH, Choi JM, Park KM, Kim LK, Sohn MH, Park JW, Lee KH, Kupper TS, Park CO (2025) Peripherally induced RORγt+ skin-resident regulatory T cells mediate the efficacy of allergen-specific immunotherapy. Sci Transl Med 17(800), eado1375.

55. Lee Y#, Park HJ#, Lee JS, Jeong HJ, Kim SM, Cho M, Woo W, Dho SH, Kim SM*, Kim LK* (2025) Epigenomic profiling of papillary thyroid carcinoma reveals distinct subtypes with clinical implications. NPJ Precis Oncol 9(1), 136.

54. Kim JY, Dho SH, Kim LK (2025) Characterization of lncRNA-Driven Networks in Portal Vein Tumor Thrombosis: Implications for Hepatocellular Carcinoma Progression. J Cancer 16(6), 1754-1767.

53. Lee KH#, Kim YO#, Dho SH#, Yong JJH, Oh HS, Lee JH, Yang SJ, Cha I, Chun J, Lee EH, Jeong SJ, Woo W, Choi JP, Han SH, Choi GB, Huh JR*, Kim LK*, Song YG* (2024) Altered gut microbiome in convalescent patients with coronavirus disease 2019. Front Cell Infect Microbiol 14, 1455295.

52. Kim W, Kim SM, Oh J, Park H, Lee J, Ryu S, Kim LK, Cho HK, Park KH, Lee JH, Park JW, Park CO (2024) Biomarkers for Short-Term Omalizumab Response in Chronic Spontaneous Urticaria. Ann Dermatol 36(6), 367-375.

51. Park KM, Kim B, Woo W, Kim LK, Hyun YM (2024) Polystyrene microplastics induce activation and cell death of neutrophils through strong adherence and engulfment. J Hazard Mater 480, 136100.

50. Chu H, Jung YW, Kim SM, Bae BG, Bae JM, Kim LK, Lee KH, Park CO (2024) Exploring the Interplay: Obesity, Lipid Metabolism, and Clinical Manifestations in Atopic Dermatitis. Ann Dermatol 36(5), 310-317.

49. Lee J, Sasaki F, Koike E, Cho M, Lee Y, Dho SH, Lee J, Lee E, Toyohara E, Sunakawa M, Ishibashi M, Hung HH, Nishioka S, Komine R, Okura C, Shimizu M, Ikawa M, Yoshimura A, Morita R*, Kim LK* (2024) Gelsolin alleviates rheumatoid arthritis by negatively regulating NLRP3 inflammasome activation. Cell Death Differ 31(12), 1679-1694.

48. Park HJ#, Kim SM#, Choi UY*, Kim LK* (2024) Multifaceted roles of trained immunity in diverse pathological contexts. BMB Rep 57(10), 431-440.

47. Choi W#, Choe MS#, Kim SM#, Kim SJ, Lee J, Lee Y, Lee SM, Dho SH, Lee MY*, Kim LK* (2024) RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1. Cell Mol Life Sci 81(1), 99.

46. Jeong J, Lee J, Talaia G, Kim W, Song J, Hong J, Yoo K, Gonzalez DG, Athonvarangkul D, Shin J, Dann P, Haberman AM, Kim LK, Ferguson SM, Choi J, Wysolmerski J (2024) Intracellular calcium links milk stasis to lysosome dependent cell death during early mammary gland involution. Cell Mol Life Sci 81(1), 29.

45. Kim JY, Lee Y, Dho SH, Park HJ, Kim DM, Lim JC, Kim SM, Kim LK (2023) Integrative analysis of circular RNA regulatory network in papillary thyroid carcinoma. Am J Cancer Res 13(9), 4446-4465.

44. Cho M#, Dho SH#, Shin S#, Lee Y, Kim Y, Lee J, Yu SJ, Park SH*, Lee KA*, Kim LK* (2022) Caspase-10 affects the pathogenesis of primary biliary cholangitis by regulating inflammatory cell death. J Autoimmun 133, 102940.

43. Hwang JH, Lee J, Choi WY, Kim MJ, Lee J, Chu KHB, Kim LK*, Kim YJ* (2022) ZNF204P is a stemness-associated oncogenic long non-coding RNA in hepatocellular carcinoma. BMB Rep 55(6), 281-286.

42. Lee Y, Dho SH, Lee J, Hwang JH, Kim MJ, Choi WY, Lee, JY, Lee J, Chang W, Lee MY, Choi J, Kim TY*, Kim LK* (2022) Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer. Exp Mol Med 54(2), 156-168.

41. Qiao L, Dho SH, Kim JY, Kim LK (2022) SEPHS1 is dispensable for pluripotency maintenance but indispensable for cardiac differentiation in mouse embryonic stem cells. Biochem Biophys Res Commun 590, 125-131.

40. Bang J, Han M, Yoo TJ, Jung J, Na J, Carlson BA, Gladyshev VJ, Hatfield DL, Kim JH, Kim LK*, Lee BJ* (2021) Identification of signaling pathways for early embryonic lethality and developmental retardation in Sephs1-/- mice. Int J Mol Sci 22(21), 11647.

39. Jung J, Kim Y, Na J, Qiao L, Bang J, Kwon D, Yoo TJ, Kang D, Kim LK, Carlson BA, Hatfield DL, Kim JH, Lee BJ (2021) Constitutive oxidative stress by SEPHS1 deficiency induces endothelial cell dysfunction. Int J Mol Sci 22(21), 11646.

38. Lee YE#, Lee J#, Lee YS, Jang JJ, Woo H, Choi HI, Chai YG, Kim TK, Kim T, Kim LK*, Choi SS* (2021) Identification and functional characterization of two noncoding RNAs transcribed from putative active enhancers in hepatocellular carcinoma. Mol Cells 44(9), 658-669.

37. Munkhjargal A, Kim MJ, Kim DY, Jeon YJ, Kee YH, Kim LK*, Kim Y* (2021) Promyelocytic leukemia proteins regulate fanconi anemia gene expression. Int J Mol Sci 22(15), 7782.

36. Lee J#, Hwang JH#, Chun H#, Woo W, Oh S, Choi J*, Kim LK* (2021) PLEKHA8P1 promotes tumor progression and indicates poor prognosis of liver cancer. Int J Mol Sci 22(14), 7614.

35. Choi WY, Hwang JH, Cho AN, Lee AJ, Jung I, Cho SW, Kim LK*, Kim YJ* (2020) NEUROD1 intrinsically initiates differentiation of induced pluripotent stem cells into neural progenitor cells. Mol Cells 43(12), 1011-1022.

34. Choi WY#, Hwang JH#, Lee JY#, Cho AN, Lee AJ, Jung I, Cho SW, Kim LK*, Kim YJ* (2020) Chromatin interaction changes during the iPSC-NPC model to facilitate the study of biologically significant genes involved in differentiation. Genes (Basel) 11(10), 1176.

33. Choi WY, Hwang JH, Cho AN, Lee AJ, Lee J, Jung I, Cho SW, Kim LK*, Kim YJ* (2020) DNA methylation of intragenic CpG islands are required for differentiation from iPSC to NPC. Stem Cell Rev Rep 16(6), 1316-1327.

32. Hwang SS, Lim J, Yu Z, Kong P, Sefik E, Xu H, Harman CCD, Kim LK, Lee GR, Li HB, Flavell RA (2020) mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence. Science 367(6483), 1255-1260.

31. Dho SH, Cho EH, Lee JY, Lee SY, Jung SH, Kim LK*, Lim JC* (2019) A novel therapeutic anti‑CD55 monoclonal antibody inhibits the proliferation and metastasis of colorectal cancer cells. Oncol Rep 42(6), 2686-2693.

30. Cho WK*, Lee CG, Kim LK* (2019) COPD as a disease of immunosenescence. Yonsei Med J 60(5), 407-413.

29. Kim MY, Lee JE, Kim LK*, Kim T* (2018) Epigenetic memory in gene regulation and immune response. BMB Rep 52(2), 127-132.

28. Kim SY, Yeo A, Noh H, Ji YW, Song JS, Kim HC, Kim LK*, Lee HK* (2018) Downregulation of IL-7 and IL-7R reduces membrane-type matrix metalloproteinase 14 in granular corneal dystrophy type 2 keratocyte. Invest Ophthalmol Vis Sci 59(13), 5693-5703.

27. Dho SH, Kim SY, Chung C, Cho EH, Lee SY, Kim JY, Kim LK, Min SW, Lee J, Jung SH, Lim JC (2018) Development of a radionuclide-labeled monoclonal anti-CD55 antibody with theranostic potential in pleural metastatic lung cancer. Sci Rep 8(1), 8960.

26. Dho SH, Lim JC, Kim LK (2018) Beyond the role of CD55 as a complement component. Immune Netw 18(1), e11.

25. Kang JS, Hwang YS, Kim LK, Lee S, Lee WB, Kim-Ha J, Kim YJ (2018) OASL1 Traps Viral RNAs in stress granules to promote antiviral responses. Mol Cells 41(3), 214-223.

24. Zhang Q, Lee WB, Kang JS, Kim LK, Kim YJ (2018) Integrin CD11b negatively regulates Mincle-induced signaling via the Lyn-SIRPa-SHP1 complex. Exp Mol Med 50(2), e439.

23. Lee WB, Yan JJ, Kang JS, Chung S, Kim LK (2017) Mycobacterial cord factor enhances migration of neutrophil-like HL-60 cells by prolonging AKT phosphorylation. Microbiol Immunol 61(12), 523-530.

22. Lee WB, Yan JJ, Kang JS, Kim LK*, Kim YJ* (2017) Macrophage C-type lectin is essential for phagosome maturation and acidification during Escherichia coli-induced peritonitis. Biochem Biophys Res Commun 493(4), 1491-1497.

21. Seo HH, Lee SY, Lee CY, Kim R, Kim P, Oh S, Lee H, Lee MY, Kim J, Kim LK, Hwang KC, Chang W (2017) Exogenous miRNA-146a enhances the therapeutic efficacy of human mesenchymal stem cells by increasing vascular endothelial growth factor secretion in the ischemia/reperfusion-injured heart. J Vasc Res 54(2), 100-108.

20. Jeong J, Kim W, Kim LK, Van Houten J, Wysolmerski JJ (2017) HER2 signaling regulates HER2 localization and membrane retention. PLoS One 12(4), e0174849.

19. Lee WB, Yan JJ, Kang JS, Zhang Q, Choi WY, Kim LK, Kim YJ (2017) Mincle activation enhances neutrophil migration and resistance to polymicrobial septic peritonitis. Sci Rep 7, 41106.

18. Hwang SS#, Kim LK#, Lee GR, Flavell RA (2016) Role of OCT-1 and partner proteins in T cell differentiation. Biochim Biophys Acta – Gene Regulatory Mechanisms 1859(6), 825-831.

17. Hwang SS, Jang SW, Kim MK, Kim LK, Kim BS, Kim HS, Kim K, Lee W, Flavell RA, Lee GR (2016) YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity. Nat Commun 7, 10789.

16. Lim S, Kim WJ, Kim YH, Lee S, Koo JH, Lee JA, Yoon H, Kim DH, Park HJ, Kim HM, Lee HG, Kim JY, Lee JU, Shin JH, Kim LK, Doh J, Kim H, Lee SK, Bothwell ALM, Suh M, Choi JM (2015) dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis. Nat Commun 6, 8244.

15. Hwang GH, Jeon YJ, Choi J, Han HJ, Lee YM, Lee S, Bae JS, Jung JW, Chang W, Kim LK, Jee JG, Lee MY (2015) The role of thioredoxin reductase and glutathione reductase in plumbagin-induced, reactive oxygen species-mediated apoptosis in cancer cell lines. Eur J Pharmacol 765, 384-393.

14. Jeon YJ, Kim SJ, Hwang GH, Wu Z, Han HJ, Park SH, Chang W, Kim LK, Lee YM, Liu KH, Lee MY (2015) Inhibition of cytochrome P450 2J2 by tanshinone IIA induces apoptotic cell death in hepatocellular carcinoma HepG2 cells. Eur J Pharmacol 764, 480-488.

13. Kim LK, Morita R, Kobayashi Y, Eisenbarth SC, Lee CG, Elias JA, Eynon EE, Flavell RA (2015) AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites. Proc Natl Acad Sci U S A 112(22), E2891-E2899.

[Highlighted in Chemical & Engineering News: Torrice M. Chopping chitin reduces allergic reactions. C&EN 93(21), p32.]

12. Hwang GH, Jeon YJ, Han HJ, Park SH, Baek KM, Chang W, Kim JS, Kim LK, Lee YM, Lee S, Bae JS, Jee JG, Lee MY (2015) Protective effect of butylated hydroxylanisole against hydrogen peroxide induced apoptosis in primary cultured mouse hepatocytes. J Vet Sci 16(1), 17-23.

11. Zorca CE#, Kim LK#, Kim YJ, Krause MR, Zenklusen D, Spilianakis CG, Flavell RA (2015) Myosin VI regulates gene pairing and transcriptional pause release in T cells. Proc Natl Acad Sci U S A 112(13), E1587-E1593.

10. Park HJ, Kim DH, Choi JY, Kim WJ, Kim JY, Senejani AG, Hwang SS, Kim LK, Tobiasova Z, Lee GR, Craft J, Bothwell ALM. Choi JM (2014) PPARγ negatively regulates T cell activation to prevent follicular helper T cells and germinal center formation. PLoS One 9(6), e99127.

9. Dilshara MG, Lee KT, Kim HJ, Lee HJ, Choi YH, Lee CM, Kim LK, Kim GY (2014) Anti-inflammatory mechanism of α-viniferin regulates lipopolysaccharide-induced release of proinflammatory mediators in BV2 microglial cells. Cell Immunol 290(1), 21-29.

8. Choi UY, Hur JY, Lee MS, Zhang Q, Choi WY, Kim LK, Lee WB, Oh GT, Kim YJ (2014) Tripartite motif-containing protein 30 modulates TCR-activated proliferation and effector functions in CD4+ T cells. PLoS One 9(4), e95805.

7. Kim LK, Esplugues E, Zorca CE, Parisi F, Kluger Y, Kim TH, Galjart NJ, Flavell RA (2014) Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells. Mol Cell 54(1), 56-66.

6. Licona-Limon P#, Kim LK#, Palm NW#, Flavell RA (2013) TH2, allergy and group 2 innate lymphoid cells. Nat Immunol 14(6), 536-542.

5. Kim LK, Choi UY, Cho HS, Lee JS, Lee WB, Kim J, Jeong K, Shim J, Kim-Ha J, Kim YJ (2007) Down-regulation of NF-κB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila. PLoS Biol 5(9), e238.

[Highlighted in preview of the issue: Schneider D. How and why does a fly turn its immune system off. PLoS Biol 5(9), e247.]

4. Park JM, Kim JM, Kim LK, Kim SN, Kim-Ha J, Kim JH, Kim YJ (2003) Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module. Mol Cell Biol 23(4), 1358-1367.

3. Kim LK, Matsufuji T, Matsufuji S, Carlson BA, Kim SS, Hatfield DL, Lee BJ (2000) Methylation of the ribosyl moiety at position 34 of selenocysteine tRNA[Ser]Sec is governed by both primary and tertiary structure. RNA 6(9), 1306-1315.

2. Xu XM, Carlson BA, Kim LK, Lee BJ, Hatfield DL, Diamond AM (1999) Analysis of selenocysteine (Ser) tRNA[Ser]Sec genes in Chinese hamsters. Gene 239(1), 49-53.

1. Xu XM, Zhou X, Carlson BA, Kim LK, Huh T, Lee BJ, Hatfield DL (1999) The zebrafish genome contains two distinct selenocystein tRNA[Ser]Sec genes. FEBS Lett 454(1-2), 16-20.