Publications
Publications
Embedded Files
这是一本深入探讨脑机接口技术发展的科普书。本书从历史进程、科学原理到最新发展和未来预测等方面，详细介绍了脑机接口技术——一 种利用思维直接控制物体的技术。作者作为该领域内的资深科学家，提供了独特 的行业视角， 揭示了技术背后的故事和挑战。通过浅显易懂的语言和丰富的实例，本书旨在填补国内该领域原创通俗读物的市场空白，让读者对这一技术有一个全面的了解，帮助读者更好地了解和评估脑机接口技术的实际应用和发展潜力。
Offers textbook coverage of the neuroelectrophysiological approaches prevalently used in neuroscience research and neuroprosthetics, including the most significant and exciting developments over the past decade
Offers clear and complete mechanistic insights to the underlying biophysics and functioning principles
Provides sound interpretations of the resulting signals and phenomena
Provides comprehensive coverage of major neural interfacing technologies
Reviews and discusses both classic and latest, emerging topics
Includes classification of technologies to provide an easy grasp of research and trends in the field
Representative Work
Representative Work
Biocircuit Engineering
Biocircuit Engineering
J. D. Prox, B. J. Seicol, H. Qi, A. Argall, N. Araya, N. Behnke, and L. Guo*, Toward Living Neuroprosthetics: Developing a Biological Brain Pacemaker as a Living Neuromodulatory Implant for Improving Parkinsonian Symptoms, Journal of Neural Engineering, vol. 18, no. 4, 046081, June 2021. [LINK]
J. D. Prox, T. Smith, C. Holl, N. Chehade, and L. Guo*, Integrated Biocircuits: Engineering Functional Multicellular Circuits and Devices, Journal of Neural Engineering, vol. 15, no. 2, 023001, April 2018. [LINK]
B. J. Seicol, S. Bejarano, N. Behnke, and L. Guo*, Neuromodulation of Metabolic Functions: From Pharmaceuticals to Bioelectronics to Biocircuits, Journal of Biological Engineering, Thematic Series on Emerging Leaders in Biological Engineering, vol. 13, no. 1, article 67, December 2019. [LINK] [Invited]
Y. Wu, M. Wang, Y. Wang, H. Yang, H. Qi, B. J. Seicol, R. Xie, and L. Guo*, A Neuronal Wiring Platform through Microridges for Rationally Engineered Neural Circuits, APL Bioengineering, vol. 4, no. 4, 046106, December 2020. [LINK]
Neural Interface Engineering
Neural Interface Engineering
L. Guo*, Principles of Functional Neural Mapping Using an Intracortical Ultra-Density Microelectrode Array (Ultra-Density MEA), Journal of Neural Engineering, vol. 17, 036018, June 2020. [LINK]
L. Guo*, On Neural Recording Using Nanoprotrusion Electrodes, Journal of Neural Engineering, vol. 17, no. 1, 016017, February 2020. [LINK]
L. Guo, G. S. Guvanasen, X. Liu, C. Tuthill, T. R. Nichols, and S. P. DeWeerth, A PDMS-Based Integrated Stretchable Microelectrode Array (isMEA) for Neural and Muscular Surface Interfacing, IEEE Transactions on Biomedical Circuits and Systems, vol. 7, no. 1, pp. 1–10, February 2013. [LINK]
L. Guo, M. Ma, N. Zhang, R. Langer, and D. G. Anderson, Stretchable Polymeric Multielectrode Array for Conformal Neural Interfacing, Advanced Materials, vol. 26, no. 9, pp. 1427–1433, March 2014. [LINK] [Inside Front Cover]
Materials and Devices
Materials and Devices
B. Yan, Y. Wang, Y. Wu, J. D. Prox, H. Yang, and L. Guo*, Fast Electrochemical Netting of Conjugated Chains for Highly Conductive Polymeric Nano Films, The Journal of Physical Chemistry B, vol. 123, no. 40, pp. 8580–8589, October 2019. [LINK] [Supplementary Cover]
B. Yan, C. Ma, Y. Zhao, N. Hu*, and L. Guo*, Geometrically Enabled Soft Electroactuators via Laser Cutting, Advanced Engineering Materials, vol. 21, no. 11, article 1900664, November 2019. [LINK] [Front Cover] [ECE News] [The Lantern]
M. Ma, L. Guo, D. G. Anderson, and R. Langer, Bio-Inspired Polymer Composite Actuator and Generator Driven by Water Gradients, Science, vol. 339, no. 6116, pp. 186–189, January 2013. [LINK] [Selected as Issue Highlights by Science Editors. Featured in a perspective paper (Science, 2013, 339, 150-151). Selected as a "Best of 2013" article by MIT]
L. Guo and S. P. DeWeerth, High-Density Stretchable Electronics: Toward an Integrated Multilayer Composite, Advanced Materials, vol. 22, no. 36, pp. 4030–4033, September 2010. [LINK]
Books
Books
Principles of Electrical Neural Interfacing: A Quantitative Approach to Cellular Recording and Stimulation, Author: L. Guo, Springer Nature Switzerland AG, August 2021. [LINK]
Neural Interface Engineering: Linking the Physical World and the Nervous System, Editor: L. Guo, Springer Nature Switzerland AG, May 2020. [LINK]
Journal Papers
Journal Papers
J. D. Prox, B. J. Seicol, H. Qi, A. Argall, N. Araya, N. Behnke, and L. Guo*, Toward Living Neuroprosthetics: Developing a Biological Brain Pacemaker as a Living Neuromodulatory Implant for Improving Parkinsonian Symptoms, Journal of Neural Engineering, vol. 18, no. 4, 046081, June 2021. [LINK]
Y. Wu, M. Wang, Y. Wang, H. Yang, H. Qi, B. J. Seicol, R. Xie, and L. Guo*, A Neuronal Wiring Platform through Microridges for Rationally Engineered Neural Circuits, APL Bioengineering, vol. 4, no. 4, 046106, December 2020. [LINK]
L. Guo*, Principles of Functional Neural Mapping Using an Intracortical Ultra-Density Microelectrode Array (Ultra-Density MEA), Journal of Neural Engineering, vol. 17, 036018, June 2020. [LINK]
L. Guo*, Perspectives on Electrical Neural Recording: A Revisit to the Fundamental Concepts, Journal of Neural Engineering, vol. 17, no. 1, 013001, February 2020. [LINK] [JNE's "Most Read" Article in March 2020]
L. Guo*, On Neural Recording Using Nanoprotrusion Electrodes, Journal of Neural Engineering, vol. 17, no. 1, 016017, February 2020. [LINK]
Y. Wu, H. Chen, and L. Guo*, Opportunities and Dilemmas of In Vitro Nano Neural Electrodes, RSC Advances, vol. 10, no. 1, pp. 187–200, January 2020. [LINK] [Invited]
B. Yan, D. An, X. Wang, B. J. DeLong, A. Kiourti, K. Dungan, J. L. Volakis, M. Ma*, and L. Guo*, Battery-Free Implantable Insulin Micropump Operating at Transcutaneously Radio Frequency-Transmittable Power, Medical Devices and Sensors, vol. 2, no. 5-6, e10055, October-December 2019. [LINK]
B. Yan, C. Ma, Y. Zhao, N. Hu*, and L. Guo*, Geometrically Enabled Soft Electroactuators via Laser Cutting, Advanced Engineering Materials, vol. 21, no. 11, article 1900664, November 2019. [LINK] [Front Cover] [ECE News] [The Lantern]
B. Yan, Y. Wang, Y. Wu, J. D. Prox, H. Yang, and L. Guo*, Fast Electrochemical Netting of Conjugated Chains for Highly Conductive Polymeric Nano Films, The Journal of Physical Chemistry B, vol. 123, no. 40, pp. 8580–8589, October 2019. [LINK] [Supplementary Cover]
B. J. Seicol, S. Bejarano, N. Behnke, and L. Guo*, Neuromodulation of Metabolic Functions: From Pharmaceuticals to Bioelectronics to Biocircuits, Journal of Biological Engineering, Thematic Series on Emerging Leaders in Biological Engineering, vol. 13, no. 1, article 67, December 2019. [LINK] [Invited]
B. Yan, Y. Wang, Y. Wu, and L. Guo*, Intrinsically Passivated Polypyrrole/Polyol-borate Soft Electroactuators, Sensors & Actuators: A. Physical, vol. 293, pp. 200–206, July 2019. [LINK]
Y. Wang, J. D. Prox, B. Yan, Y. Wu, A. D. Argall, and L. Guo*, ZnO Nanorod Array as an Inhibitory Biointerface, MRS Communications, vol. 8, no. 4, pp. 1381–1386, December 2018. [LINK] [Invited]
Y. Wang, H. Zhu, H. Yang, A. D. Argall, L. Luan, C. Xie*, and L. Guo*, Nano Functional Neural Interfaces, Nano Research, Special Issue for Young Innovators in Nanobiotechnology, vol. 11, no. 10, pp. 5065–5106, October 2018. [LINK] [Invited]
M. Heard, J. Ford, N. Yene, B. Straiton, P. Havanas, and L. Guo*, Advancing the Neurocomputer, Neurocomputing, vol. 284, no. 1, pp. 36–51, April 2018. [LINK]
J. D. Prox, T. Smith, C. Holl, N. Chehade, and L. Guo*, Integrated Biocircuits: Engineering Functional Multicellular Circuits and Devices, Journal of Neural Engineering, vol. 15, no. 2, 023001, April 2018. [LINK]
Y. Wu and L. Guo*, Enhancement of Intercellular Electrical Synchronization by Conductive Materials in Cardiac Tissue Engineering, IEEE Transactions on Biomedical Engineering, vol. 65, no. 2, pp. 264–272, February 2018. [LINK] [Featured Article] [February 2018 TBME Monthly Highlights] [ECE News]
B. Yan, Y. Wu, and L. Guo*, Recent Advances on Polypyrrole Electroactuators, Polymers, Special Issue on "Electroactive Polymers and Gels", vol. 9, no. 9, article 446, September 2017. [LINK] [Invited]
B. Yan, Y. Wang, X. Jiang, K. Liu, and L. Guo*, Flexible Photocatalytic Composite Film of ZnO-Microrods/Polypyrrole, ACS Applied Materials & Interfaces, vol. 9, no. 34, pp. 29113–29119, August 2017. [LINK]
Y. Wang, Y. Wu, F. Quadri, J. D. Prox, and L. Guo*, Cytotoxicity of ZnO Nanowire Arrays on Excitable Cells, Nanomaterials, Special Issue on “Nanoparticle-Mediated Cell and Tissue Stimulation”, vol. 7, no. 4, article 80, April 2017. [LINK] [Invited]
L. Guo*, The Pursuit of Chronically Reliable Neural Interfaces: A Materials Perspective, Frontiers in Neuroscience, vol. 10, article 599, December 2016. [LINK]
Y. Wang and L. Guo*, Nanomaterial-Enabled Neural Stimulation, Frontiers in Neuroscience, vol. 10, article 69, March 2016. [LINK]
B. Yan, B. Li, F. Kunecke, Z. Gu, and L. Guo*, Polypyrrole-Based Implantable Electroactive Pump for Controlled Drug Microinjection, ACS Applied Materials & Interfaces, vol. 7, no. 27, pp. 14563–14568, July 2015. [LINK]
G. S. Guvanasen, L. Guo, R. J. Aguilar, A. L. Cheek, C. S. Shafor, S. Rajaraman, T. R. Nichols, and S. P. DeWeerth, A Stretchable Microneedle Electrode Array for Stimulating and Measuring Intramuscular Electromyographic Activity, IEEE Transactions on Neural Systems and Rehabilitation Engineering, vol. 25, no. 9, pp. 1440–1452, September 2017. [LINK]
L. Guo, M. Ma, N. Zhang, R. Langer, and D. G. Anderson, Stretchable Polymeric Multielectrode Array for Conformal Neural Interfacing, Advanced Materials, vol. 26, no. 9, pp. 1427–1433, March 2014. [Inside Front Cover]
L. Guo, G. S. Guvanasen, X. Liu, C. Tuthill, T. R. Nichols, and S. P. DeWeerth, A PDMS-Based Integrated Stretchable Microelectrode Array (isMEA) for Neural and Muscular Surface Interfacing, IEEE Transactions on Biomedical Circuits and Systems, vol. 7, no. 1, pp. 1–10, February 2013.
M. Ma, L. Guo, D. G. Anderson, and R. Langer, Bio-Inspired Polymer Composite Actuator and Generator Driven by Water Gradients, Science, vol. 339, no. 6116, pp. 186–189, January 2013. [LINK] [Selected as Issue Highlights by Science Editors. Featured in a perspective paper (Science, 2013, 339, 150-151). Selected as "Best of 2013" by MIT]
Media Reports: Science, MIT News, C&EN, Boston Globe, NBC News, physicsworld.com, Science Recorder, TechNewsDaily, Txchnologist, Smithsonian.com, DVICE, Ars Technica, Newscientist, ScienceDaily, gizmag, Knovel, Electronic Products
K. W. Meacham, L. Guo, S. P. DeWeerth, and S. Hochman, Selective Stimulation of the Spinal Cord Surface Using a Stretchable Microelectrode Array, Frontiers in Neuroengineering, vol. 4, article 5, April 2011.
L. Guo and S. P. DeWeerth, An Effective Lift-Off Method for Patterning High-Density Gold Interconnects on an Elastomeric Substrate, Small, vol. 6, no. 24, pp. 2847–2852, December 2010.
L. Guo, K. W. Meacham, S. Hochman, and S. P. DeWeerth, A PDMS-Based Conical-Well Microelectrode Array for Surface Stimulation and Recording of Neural Tissues, IEEE Transactions on Biomedical Engineering, vol. 57, no. 10, pp. 2485–2494, October 2010.
L. Guo and S. P. DeWeerth, High-Density Stretchable Electronics: Toward an Integrated Multilayer Composite, Advanced Materials, vol. 22, no. 36, pp. 4030–4033, September 2010.
S. A. Desai, J. D. Rolston, L. Guo, and S. M. Potter, Improving Impedance of Implantable Microwire Multi-Electrode Arrays by Ultrasonic Electroplating of Durable Platinum Black, Frontiers in Neuroengineering, vol. 3, article 5, May 2010.
K. W. Meacham, R. J. Giuly, L. Guo, S. Hochman, and S. P. DeWeerth, A Lithographically-Patterned, Elastic Multi-Electrode Array for Surface Stimulation of the Spinal Cord, Biomedical Microdevices, vol. 10, no. 2, pp. 259–269, April 2008.
Patents
Patents
B. Yan, Y. Wang, and L. Guo, Passivated Conductive Films, and Electroactuators Containing Same, WO2019165234A1.
A. Srinivasan, L. Guo, Y. Choi, and R. V. Bellamkonda, Regenerative Microchannel Electrode Array for Peripheral Nerve Interfacing, WO2012139124A1.
G. S. Guvanasen, S. Rajaraman, R. Aguilar, Jr., L. Guo, T. R. Nichols, and S. P. DeWeerth, 3D Microelectrode Device for Live Tissue Applications, US 9248273.
M. Ma, L. Guo, D. G. Anderson, O. C. Farokhzad, and R. S. Langer, A Bio-inspired Polymer Composite Actuator Driven by Water Gradient and Methods of Making the Same, US 9236556.
L. Guo and S. P. DeWeerth, Integrated Method for High-Density Interconnection of Electronic Components through Stretchable Interconnects, US 8349727.
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