Publications

Xue, D.; Zou, H.; Qiu, Y.; Lv, W.; Madden, M. D.; Lian, X.; Xu, M.; Pulliam, C.; Older, E. A.; Campbell, A.; der Rond, T.; Awakawa, T.; Yuan, C.; Moore, B. S.; Li, J. Discovery of acylsulfenic acid-featuring natural product sulfenicin and characterization of its biosynthesis. Nature Chemistry, 2025, DOI: 10.1038/s41557-025-01833-9.

Older, E. A.; Mitchell, M.; Campbell, A.; Lian, X.; Madden, M.; Wang, Y.; VanderVeen, B.; Tatum, R.; Murphy, E. A.; Chen, Y.; Fan, D.; Ellermann, M.; Li, J. Human gut commensal Alistipes timonensis modulates the host lipidome and delivers anti-inflammatory outer membrane vesicles to suppress colitis in an Il10-deficient mouse model. Gut Microbes, 2025, 17(1), DOI: 10.1080/19490976.2025.2517380. 

Xue, D.; Wu, Q.; Hou L.; Pulliam, C.; Xu, M.; Madden, M. D.; Madu, J.; Li, Y.; Liu, S.; Fan, D.; Bugni, T. S.; Wang, T.; Li, J. Discovery and biosynthetic interrogation of a cobalt-containing terpene-polyketide-nonribosomal peptide tribrid with anticoronavirus activity. Journal of the American Chemical Society, 2025, DOI: 10.1021/jacs.5c16450.

Older, E. A.; Zhang, J.; Ferris, Z. E.; Xue, D.; Zhong, Z.; Mitchell, M.; Madden, M.; Wang, Y.; Chen, H.; Nagarkatti, P.; Nagarkatti, M.; Fan, D.; Ellermann, M.; Li, Y.; Li, J. Biosynthetic enzyme analysis identifies a protective role for TLR4-acting gut microbial sulfonolipids in inflammatory bowel disease. Nature Communications, 2024, 15, 9371, DOI: 10.1038/s41467-024-53670-y

Xue, D.; Xu, M.; Madden, M. D.; Lian, X.; Older, E. A.; Pulliam, C.; Hui, Y.; Shang, Z.; Gupta, G.; Keerthi, M. R.; Wang, Y.; Sardi, A.; Long, Y.; Chen, H.; Fan, D.; Bugni, T. S.; Testerman, L. T.; Wu, Q.; Li, J. Discovery of a chimeric polyketide family as cancer immunogenic chemotherapeutic leads. Journal of the American Chemical Society, 2024, DOI: 10.1021/jacs.4c09582.

Xue, D.; Shang, Z.; Older, E. A.; Zhong, Z.; Pulliam, C.; Peter, K.; Nagarkatti, M.; Nagarkatti, P.; Li, Y.; Li, J. Refactoring and heterologous expression of class III lanthipeptide biosynthetic gene clusters lead to the discovery of N,N-dimethylated lantibiotics from Firmicutes. ACS Chemical Biology, 2023, DOI: 10.1021/acschembio.2c00849

Hou, L.; Tian, H.; Wang, L.; Ferris, Z. E.; Wang, J.; Cai, M.; Older, E. A.; Raja, M.; Xue, D.; Sun, W.; Nagarkatti, P.; Nagarkatti, M.; Chen, H.; Fan, D.; Tang X.; Li, J. Identification and biosynthesis of pro-inflammatory sulfonolipids from an opportunistic pathogen Chryseobacterium gleum. ACS Chemical Biology, 2022, DOI: 10.1021/acschembio.2c00141.

Xue, D.; Older, E. A.; Zhong, Z.; Shang, Z.; Chen, N.; Dittenhauser, N.; Hou, L.; Cai, P.; Walla, M.; Dong, S.; Tang, X.; Chen, H.; Nagarkatti, P.; Nagarkatti, M.; Li, Y.; Li, J. Correlational networking guides the discovery of unclustered lanthipeptide protease-encoding genes. Nature Communications, 2022, 13, 1647, DOI: 10.1038/s41467-022-29325-1