Publications
Choi HS, Bhat A, Howington M, Schaller ML, Cox RE, Huang S, Beydoun S, Miller HA, Jensen L, Tuckowski AM, Mecano J, Dean ES, Beard D, Evans C, and Leiser SF. FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans. Nat Commun 14, 562 (2023). https://doi.org/10.1038/s41467-023-36181-0
Miller HA*, Huang S*, Schaller ML, Dean ES, Tuckowski AM, Munneke AS, Beydoun S, Pletcher SD, and Leiser SF. Serotonin and dopamine modulate aging in response to food odor and availability. Nat Commun 13, 3271 (2022). https://doi.org/10.1038/s41467-022-30869-5
Beydoun S, Choi HS, Dela-Cruz G, Kruempel J, Huang S, Bazopoulou D, Miller HA, Schaller ML, Evans CR, Leiser SF (2021). "An alternative food source for metabolism and longevity studies in Caenorhabditis elegans," Comms Bio 4(258)
Huang S, Howington M, Dobry C, Evans CR, Leiser SF (2021). "Flavin-containing monooxygenases are conserved regulators of stress resistance and metabolism," Front. Cell Dev. Biol
Miller HA, Dean ES, Pletcher SD, Leiser SF (2020). "Cell non-autonomous regulation of health and longevity," Elife 10;9:e62659
Kruempel JCP, Miller HA, Schaller ML, Fretz A, Howington M, Sarker M, Huang S, Leiser SF (2020). "Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response," Geroscience 42(6):1621-1633
Kruempel JCP, Howington MB, Leiser SF (2019). "Computational tools for geroscience," Transl Med Aging 3:132-143
Miller HA, Fletcher M, Primitivo M, Leonard A, Sutphin GL, Rintala N, Kaeberlein M, and Leiser SF (2017). “Genetic interaction with temperature is an important determinant of nematode longevity,” Aging Cell 16(6): 1425-29
Mendenhall A, Crane MM, Leiser SF, Sutphin G, Tedesco PM, Kaeberlein M, Johnson TE, Brent R (2017). "Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans," J. Gerontol. A Biol. Sci. Med. Sci. 72(8): 1033-37
Rossner R, Kaeberlein M, and Leiser SF (2017) “Flavin- containing monooxygenases in aging and disease: emerging roles for ancient enzymes,” JBC 292 (27): 11138-46
Leiser SF, Jafari G, Primitivo M, Sutphin GL, Dong J, Leonard A, Fletcher M, and Kaeberlein M (2016) “Age-associated vulval integrity is an important marker of nematode healthspan,”AGE 38(5-6): 419-31
Leiser SF, Rossner RJ, and Kaeberlein M (2016). “New insights into cell non-autonomous mechanisms of the C. elegans hypoxic response,” Worm. Apr 12;5(2)
Leiser SF, Miller H, Rossner R, Fletcher M, Leonard A, Primitivo M, Rintala N, Ramos FJ, Miller DL, Kaeberlein M (2015). “Cell nonautonomous activation of Flavin-containing monooxygenase promotes longevity and health span.” Science 350 (6266): 1375-8.
Leiser SF, Fletcher M, Begun A, Kaeberlein M (2013). “Life-Span Extension From Hypoxia in Caenorhabditis elegans Requires Both HIF-1 and DAF-16 and Is Antagonized by SKN-1” J. Gerontol. A Biol. Sci. Med. Sci. Oct;68(10):1135-44.
Leiser SF, Begun A and Kaeberlein M (2011). “HIF-1 and hypoxia interact with DAF-16 and temperature to modulate life span,” Aging Cell 10(2): 318-26
Leiser SF and Kaeberlein M (2010). “The hypoxia inducible factor HIF-1 functions as both a positive and negative modulator of aging,” Biol Chem. 391(10): 1131-7,
Leiser SF and Kaeberlein M. (2010) “A role for SIRT1 in the hypoxic response,” Molecular Cell. 38(6): 779-80
Leiser SF and Miller RA (2010). “Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice,” Mol Cell Biol. 30(3): 871-84
Page MM, Salmon AB, Leiser SF, Robb EL, Brown MF, Miller RA, and Stuart JA (2009). “Mechanisms of stress resistance in Snell dwarf mouse fibroblasts: enhanced antioxidant and DNA base excision repair capacity, but no differences in mitochondrial metabolism,” Free Radic Biol Med. 46(8): 1109-18
Harper JM, Salmon AB, Leiser SF, Galecki AT, and Miller RA (2007). "Skin-derived fibroblasts from long-lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone," Aging Cell 6:1-13
Leiser SF, Salmon AB, and Miller RA (2006). "Correlated resistance to glucose deprivation and cytotoxic agents in fibroblast cell lines from long-lived pituitary dwarf mice," Mech Ageing Dev. 127:821-829