Leiderman Research Group

RESEARCH AREAS

Mathematical biology
Mathematical modeling blood coagulation
Computational biofluid dynamics

ABOUT DR. LEIDERMAN

Professor in the Department of Biochemistry and Biophysics, Adjunct Professor in the Department of Mathematics, and faculty in the Computational Medicine Program at UNC Chapel Hill
Dr. Leiderman is a mathematical biologist interested in the biochemical and biophysical aspects of blood clotting and emergent behavior in biological fluid-structure interaction problems. She especially loves mathematical modeling, where creativity, biological knowledge, and mathematical insight meet. A major goal in the Leiderman Research Group is to use mathematical and computational modeling as a tool to learn something new about a biological system, and generate testable hypotheses. Our research includes an integration of mathematical and experimental approaches, together with statistical analyses and inference, to determine mechanisms underlying complex biological phenomena. This paradigm culminates in the contextualization of our findings to both the mathematical and biological communities.

Dr. Karin Leiderman

Contact: karinlg@unc.edu

NEWS!

November 2024
- Jamie Madrigal defends her PhD thesis! Congratulations Dr. Madrigal!!! Jamie is off to work for Certara!
- Jake Grdadolnik passes his thesis proposal defense!
- Savannah Howard passes her MS defense!
- Lexi Whiteside defends her Honor's Undergraduate Thesis!
- Kenji's paper on Concizumab is published in JTH!! Examining downstream effects of concizumab in hemophilia A with a mathematical modeling approach
- Our paper on TFPI reaction schemes in published in PLoS Comp Bio: "A new look at TFPI inhibition of factor X activation"
October 2024
- Han Cao passes his MS defense!
- Our Paper in RPTH is published: "Mathematical modeling identifies clotting factor combinations that modify thrombin generation in normal and factor VIII-, IX-, or XI-deficient blood"
June 2024
- Jamie's paper "Modeling the distribution of enzymes on lipid vesicles: A novel framework for surface-mediated reactions in coagulation" is published in Mathematical Biosciences Congratulations, Jamie!
- Showing up at SIAM Life Sciences! Dave Montgomery, Jamie Madrigal, and Dr. Leiderman all give invited talks in Portland, OR this year.
May 2024
- Laura Albrecht successfully defends PhD thesis and is off to CDC for a research fellowship!
April 2024
- Jamie Madrigal and Lexi Whiteside present posters at Hemostasis Conference. Congratulations, Jamie for winning a poster prize!

OLD NEWS, BUT STILL GREAT NEWS!

Nov 2023: Big group showing at TRICAMS at Duke University!
- Dr. Leiderman gives plenary talk
- Lexi Whiteside wins best undergraduate poster at TRICAMS on her work modeling the intrisic pathway of coagulation!!! Go, Lexi!
- Han Cao presents his poster on lipid mediated enzyme kinetics using an agent based approach.
October 2023: Dr. Leiderman gives organizes session on women's health and gives talk at AWM Research Symposium in Atlanta, GA
July 2023: Dr. Leiderman gives a talk at SMB in Columbus, OH, on modeling the effects of estrogen on platelet activation (Banff team research project).
July 2023: Dave Montgomery successfully defends his thesis! Congratulations, Dave!
June 2023: Dr. Leiderman gives two talks at ISTH in Montreal!
January 2023: Kenji Miyazawa's papers are published in Biophysical Journal
September 2022: Michael Kelley's paper "Mathematical modeling to understand the role of bivalent thrombin-fibrin binding during polymerization" is published in PLOS Comp Biol! Check it out here!
August 2022: Leiderman Research Group has moved to UNC Chapel Hill!!!!!!
Dr. Leiderman gives State-of-the-Art talk at ISTH 2022 in London
October 2021: Our review paper on mathematical modeling of fibrin polymerization is out in Current Opinion in Biomedical Engineering: Check it out here!
June 2021: Leiderman group represents at SMB!
April 2021: PhD student Jamie Madrigal wins 3rd place poster prize in the Mines Graduate Research and Discovery Symposium! Go Jamie!!!
April 2021: Dr. Leiderman wins the Mines Faculty Excellence Award!
January 2021: Dr. Leiderman wins the Mines Martin Luther King Jr. Recognition award for mentoring.
Fall 2020: Our review papers "Computationally Driven Discovery in Coagulation" and "The Art and Science of Building a Computational Model to Understand Hemostasis" were published in ATVB and Seminars in Thrombosis and Hemostasis!
October 2020: Kenji Miyazawa successfully passed his qualifying exam today with a proposal to develop a new mathematical model of Protein S interactions in coagulation. He has officially advanced to candidacy. Congratulations, Kenji!
August 2020: Joint work on "A Mathematical Model of Platelet Aggregation in an Extravascular Injury Under Flow" was accepted in SIAM Multiscale Modeling! Congratulations to students Kathryn Link (U Utah), Nick Danes (Mines) and Matt Sorrells Mines CBE)
August 2020: Jamie Madrigal successfully passed her Applied Math and Computational Math qualifying exams! She has officially advanced to candidacy. Congratulations, Jamie!
July 2020: Our paper "A Minimal Model of the Hydrodynamical Coupling of Flagella on a Spherical Body" was accepted in Physical Review E! Check it out here! Congrats Forest Mannan and Miika Jarvela!
May 2020: Dr. Leiderman wins the Mines Excellence in Research Award for Junior Faculty and the W.M. Keck Graduate Student Mentorship Award!
April 2020: Forest Mannan's paper "Weak inertial effects on arbitrarily shaped objects in the presence of a wall" published in Physical Review Fluids! Check it out here!
Our NIH R01 "An integrated computational and experimental approach to understanding the hemostatic response during treatment of bleeding" has been funded!!! I am beyond excited to start this work with Keith Neeves, Aaron Fogelson, Suzanne Sindi, and Mac Monroe!!!
September 2019: Our paper "A mathematical model of coagulation under flow identifies factor V as a modifier of thrombin generation in hemophilia A" has been accepted in Journal of Thrombosis and Hemostasis. Check it out here!
Michael Kelley's paper "A Mathematical Model of Bivalent Binding Suggests Physical Trapping of Thrombin within Fibrin Fibers" has been accepted in Biophysical Journal! Check it out here!
8/6/19 Nicholas Danes successfully defends his PhD thesis. Congratulations, Dr. Danes! Nick will move on to be a Computational Scientist at Ball Aerospace in Albuquerque, NM! Good luck, Nick!
6/24/19 Michael Stobb successfully defends his PhD thesis. Congratulations, Dr. Stobb!! Michael will move on to a tenure-track position in the Mathematics & Computer Science department at Coe College
6/20/19 Dr. Leiderman is awarded NSF CAREER Award entitled "Mathematical Modeling to Identify New Regulatory Mechanisms of Blood Clotting"
5/12/19 Michael Stobb's paper "Assessing the impact of product inhibition in a chromogenic assay" was accepted in Analytical Biochemistry and is now available online!
5/2/19 Nick Danes' paper "A density‐dependent FEM‐FCT algorithm with application to modeling platelet aggregation" was accepted in the International Journal of Numerical Methods in Bioengineering and is now available online!

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