A major interest of the lab is to find out new bacterial species which can degrade plastics including polyethylene, polypropylene, polystyrene, etc. Specifically bacteria isolated from insect larvae gut can degrade plastics.
Identification of plastic-degrading enzymes and genes
We have a long-standing interest in identifying enzymes and genes which are involved in plastic degradation.
Engineering plastic-degrading enzymes and development of new bacteria for plastic degradation
Our lab will use both in vivo and in vitro approaches to engineer plastic-degrading enzymes. Our working hypothesis is that the catalytic activity of enzyme can be significantly improved using genetic engineering. The introduction of genes encoding plastic-degrading enzymes into bacteria will be a novel solution to environmental plastic waste.
The biological effect of microplastics absorption and accumulation
We also have an interest in the biological effect of microplastics, including how microplastics are absorbed and accumulated in the body. We have been particularly interested in how microplastics affect mammalian metabolism. We will begin this project using organoid culture and animal model.