Limitless Makers

LIMITLESS MAKERS UYGULAMALARI

Prof.Dr.Levent ÇAVAŞ

10 Ağustos 2022 

Uluslararası Gençlik Merkezi, İstanbul, Türkiye

Uygulamalarda Kullanılacak Web Adresleri:

Uniprot: https://www.uniprot.org/

ProtParam: https://web.expasy.org/protparam/

Clustal Omega: https://www.ebi.ac.uk/Tools/msa/clustalo/

BLASTp ve BLASTn: https://blast.ncbi.nlm.nih.gov/Blast.cgi

CB-Docking: https://cadd.labshare.cn/cb-dock2/php/index.php

Protein Databank: https://www.rcsb.org/

Chemical Databank: https://pubchem.ncbi.nlm.nih.gov/

Molekül Çizmek için: http://www.swisssimilarity.ch/

UYGULAMALAR

Uygulama-1

gamma-glutamil-sisteinil-glisin yapısını çiziniz

Uygulama-2

Aşağıdaki protein örmeğindeki amino asit sayılarını ve yüzdelerini bulunuz.

>sp|P00441|SODC_HUMAN Superoxide dismutase [Cu-Zn] OS=Homo sapiens OX=9606 GN=SOD1 PE=1 SV=2

MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ

Uygulama-3

Aşağıdaki proteinlerdeki benzerlikleri uygun araçlar kullanılarak ifade ediniz.

>sp|P00441|SODC_HUMAN Superoxide dismutase [Cu-Zn] OS=Homo sapiens OX=9606 GN=SOD1 PE=1 SV=2

MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ

>sp|P10791|SODC_DROVI Superoxide dismutase [Cu-Zn] OS=Drosophila virilis OX=7244 GN=Sod1 PE=3 SV=2

MVVKAVCVINGDAKGTVFFEQEGEGCPVKVTGEVTGLAKGQHGFHVHEFGDNTNGCMSSGPHFNPYQKEHGAPTDENRHLGDLGNIIANGDGPTPVNICDCKITLLGANSIIGRTVVVHADPDDLGKGGHELSKTTGNAGARIGCGVIGIAKI

>sp|P09212|SODC_RABIT Superoxide dismutase [Cu-Zn] OS=Oryctolagus cuniculus OX=9986 GN=SOD1 PE=1 SV=3

MATKAVCVLKGDGPVEATIHFEQKGTGPVVVKGRITGLTEGLHEFHVHQFGDNRQGCTSAGPHFNPLSKKHGGPKDEERHVGDLGNVTAGSNGVADVLIEDSVISLSGDMSVIGRTLVVHEKEDDLGKGGNDESTKTGNAGSRLACGVIGISP

Uygulama-4

Hangi iki tür birbirine daha benzerdir?

>sp|P00674|RNAS1_HORSE Ribonuclease pancreatic OS=Equus caballus OX=9796 GN=RNASE1 PE=1 SV=1

KESPAMKFERQHMDSGSTSSSNPTYCNQMMKRRNMTQGWCKPVNTFVHEPLADVQAICLQ KNITCKNGQSNCYQSSSSMHITDCRLTSGSKYPNCAYQTSQKERHIIVACEGNPYVPVHFDASVEVST

>sp|P00686|RNAS1_OSPRU Ribonuclease pancreatic OS=Osphranter rufus OX=9321 GN=RNASE1 PE=1 SV=1

ETPAEKFQRQHMDTEHSTASSSNYCNLMMKARDMTSGRCKPLNTFIHEPKSVVDAVCHQE NVTCKNGRTNCYKSNSRLSITNCRQTGASKYPNCQYETSNLNKQIIVACEGQYVPVHFDAYV

>sp|P00673|RNAS1_BALAC Ribonuclease pancreatic OS=Balaenoptera acutorostrata OX=9767 GN=RNASE1 PE=1 SV=1 RESPAMKFQRQHMDSGNSPGNNPNYCNQMMMRRKMTQGRCKPVNTFVHESLEDVKAVCSQ KNVLCKNGRTNCYESNSTMHITDCRQTGSSKYPNCAYKTSQKEKHIIVACEGNPYVPVHFDNSV

Uygulama-5

Aşağıdaki sekansların ne olduğunu bulunuz.

Örnek-1

MCAARLAAAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTVRDYTQMN

ELQRRLGPRGLVVLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGA

GAHPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYS

RRFQTIDIEPDIEALLSQGPSCA

Örnek-2

ATGTGGCGCACAACGAGTTTCCTAGGCCGATAGGATTATTGTCTCCTAGCCCGTATCTCCAGGATCCAGG CCATATCCCTGCTCCCAGTGGTTTCCATCACGTGTCCTTGCTTATTTGTGTTGTGGTGATTGTGTCTCAG CCTAGGAGACACTGGGCAATCTGAGAGAGCGCTACGTGACTGGGCTAGACTTTTGTAATTGTTGGTCTTG AACGAGGAATGCCTAGTAATCGTAGGTCATTATCCTGCGATGATTATGTCCCTGCCCTTTGTACACACCG CCCGTCGCTCCTGCCGTGGCTCGTGCCGGTGAAGAGGGGGAGGCAGCGTCAACGGAGTAACATCTGATTG TACGTGGAACCCCTCTGAACCTTCGCGAGTAGAGGAAGGAGAAGTCGTAACAAGGTTTTCGTAGGTGAAC CTGCGAAAGGATCATTATCGGCAAATTCTATATATGTATACACTACTGTGTGTCTATATTCTTTGTGTAA AGACATGGCTATGTTGTAATGAATGTGTTGCTGTTATTGTCTAAAGCATGCGTAGTGGACGGCTCGGTTC CCGTGTCGATGAAGGACGTAGCGAAATACGAAAGGTGTTGCGAATTGCAAGATTTCGTGAGTCAATGAAT ATCCGAATGCATTGTCGTCCCTTCGCAGCTTCGGTTGCAAGGGGCGCGTCGGCAACATCGGCTAATTGTC GACCTTCATAGGCTCTCTAGTGAACACTCTCTTACTGAGAGAGGTTGCTCGACTCTATGAAGCAGTGGTT CAGTGAGCAAGCATTCCATACGCGATGTGGCTATGCTTGTGACGACTCCCTCTCACTATCGACTACTGAC TGAGATTAACGACAGTATTGTGACTTGCATACTCTATGTGCTTGTCCTATAGCAATCAATCGCTGAGATT GAATGCCTAGAAACTGTGCTCAGCAATAGTAGTCAGGTGTCAGAACGTGTATCTTATTA

Uygulama-6

SARS-CoV-2 için bir ilaç öneriniz. Aşağıdaki makaleyi örnek olarak kullanabilirsiniz.

https://chemrxiv.org/engage/chemrxiv/article-details/62b9de5e1278ae4154f25fca

Amino Asit Tabloları