Lee, M., Kim, S.Y., Park, T., Yoon, S.-E., Kim, Y.-J., Joo, K.M., Kwon, J.Y., Kim, K., and Kang, K. (2025). An evolutionarily conserved cation channel tunes the sensitivity of gustatory neurons to ephaptic inhibition in Drosophila. Proceedings of the National Academy of Sciences 122, e2413134122. https://doi.org/10.1073/PNAS.2413134122.
Lee, M., Park, S. H., Joo, K. M., Kwon, J. Y., Lee, K.-H., & Kang, K. (2024). Drosophila HCN mediates gustatory homeostasis by preserving sensillar transepithelial potential in sweet environments. eLife, 13. https://doi.org/10.7554/ELIFE.96602.1
Lee, M., Kim, S. Y., Park, T., Joo, K. M., Kwon, J. Y., Kim, K., & Kang, K. (2023). Unilateral ephaptic program underlying sweetness dominance. BioRxiv, 2023.08.04.551918. https://doi.org/10.1101/2023.08.04.551918
Du, E. J., & Kang, K. (2020). A Single Natural Variation Determines Cytosolic Ca2+-Mediated Hyperthermosensitivity of TRPA1s from Rattlesnakes and Boas. Molecules and Cells, 43(6), 572–580. https://doi.org/10.14348/MOLCELLS.2020.0036
Du, E.J., Ahn, T.J., Sung, H., Jo, H., Kim, H.-W., Kim, S.-T., and Kang, K. (2019). Analysis of phototoxin taste closely correlates nucleophilicity to type 1 phototoxicity. Proc. Natl. Acad. Sci. 116(24):12013-12018.
Lee, M.J., Sung, H.Y., Jo, H., Kim, H.-W., Choi, M.S., Kwon, J.Y., and Kang, K. (2017). Ionotropic Receptor 76b Is Required for Gustatory Aversion to Excessive Na+ in Drosophila. Mol. Cells 40 (10), 787-795.
Du, E.J., Ahn, T.J., Wen, X., Seo, D.-W., Na, D.L., Kwon, J.Y., Choi, M., .... Kang, K. (2016). Nucleophile sensitivity of Drosophila TRPA1 underlies light-induced feeding deterrence. Elife 5, e18425.
Du, E.J., Ahn, T.J., Kwon, I., Lee, J.H., Park, J.-H., Park, S.H., … Kang, K. (2016). TrpA1 Regulates Defecation of Food-Borne Pathogens under the Control of the Duox Pathway. PLoS Genet. 12, e1005773.
Kang, K. (2016). Exceptionally high thermal sensitivity of rattlesnake TRPA1 correlates with peak current amplitude. Biochim. Biophys. Acta 1858, 318–325.
Du, E.J., Ahn, T.J., Choi, M.S., Kwon, I., Kim, H.-W., Kwon, J.Y., and Kang, K. (2015). The Mosquito Repellent Citronellal Directly Potentiates Drosophila TRPA1, Facilitating Feeding Suppression. Mol. Cells 38, 911–917.
Kang, K.*, Panzano, V.*, Chang, E.C., Ni, L., Dainis, A.M., Jenkins, A.M. Regna, K., Muskavitch, M.A.T. and Garrity P.A. (2012) Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila. Nature, 481, 76-80.
Highlighted in
1) Research Highlight: Sian Lewis (2012) Sensory transduction: How TRPs discriminate between different stimuli. Nature Reviews Neuroscience, 13:74
2) Commentary: Andrew P Braun (2012) Structural remodeling of N-terminus tunes TRPA1 channel activation and regulates behavioral responses in Drosophila. Channels, 6(1)
Panzano, V.*, Kang, K.*, and Garrity P.A. (2010) Infrared snake eyes: TRPA1 and the thermal sensitivity of the snake pit organ. Science Signaling, 3, pe22.
Kang K., Pulver, S.R., Panzano, V.C., Chang, E.C., Griffith, L.C., Theobald, D.L. and Garrity P.A. (2010) Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception. Nature, 464, 597-600.
Highlighted in
1) News and Views: L.J. Macpherson and A. Patapoutian, (2010) Channels: flies feel your pain. Nature Chemical Biology, 6:252-253.
2) Leading Edge: M. Doucleff. (2010) Flies flee the sushi bar. Cell, 141: 375.
3) Faculty of 1000 evaluated by M. Andresen and others
Hamada, F.N., Rosenzweig, M., Kang, K., Pulver, S.R., Ghezzi, A., Jegla, T.J., and Garrity, P.A. (2008). An internal thermal sensor controlling temperature preference in Drosophila. Nature 454, 217-220.
Kinjo,T.G.*, Kang,K.*, Szerencsei,R.T., Winkfein,R., and Schnetkamp,P.P. (2005). Site-directed disulfide mapping of residues contributing to the Ca2+ and K+ binding pocket of the NCKX2 Na+/Ca2+-K+ exchanger, Biochemistry 44, 7787-7795,
Kang,K.*, Shibukawa Y.*, Szerencsei,R.T., and Schnetkamp,P.P. (2005). Substitution of a single residue, Asp575, renders the NCKX2 K+-dependent Na+/Ca2+ exchanger independent of K+. Journal of Biological Chemistry, 680, 2834-2839.
Kang,K., Kinjo,T.G., Szerencsei,R.T., and Schnetkamp,P.P. (2005). Residues contributing to the Ca2+ and K+ binding pocket of the NCKX2 Na+/Ca2+-K+ exchanger. Journal of Biological Chemistry, 680, 2823-2833.
Kang,K. and Schnetkamp,P.P. (2003). Signal sequence cleavage and plasma membrane targeting of the rod NCKX1 and cone NCKX2 Na+/Ca2+-K+ exchangers. Biochemistry 42, 9438-9445.
Kang,K., Bauer,P.J., Kinjo,T.G., Szerencsei,R.T., Bonigk,W., Winkfein,R., and Schnetkamp,P.P. (2003). Assembly of Retinal Rod and Cone Na/Ca-K exchangers oligomers with cGMP-gated channels as probed with heterologously expressed cDNAs. Biochemistry 42, 4593-4600.