I aim to unravel the impact of Pseudomonas aeruginosa microRNAs on microbe-host interaction and drug response in chronic respiratory diseases.

This is my first awarded project as a young PI at Università Vita-Salute San Raffaele in Milan and is founded by Fondazione Cariplo. Dr. Bragonzi at the San Raffaele Scientific Institute is my project mentor, Prof. Malerba at the University of Verona and Prof. Ghanbari at Erasmus MC in Rotterdam are partners of the project.

We are characterizing a novel mouse model for Cystic Fibrosis studies, including the cell-types composition of their lungs with single-nucleus RNA sequencing.

This work is in collaboration with Dr. Bragonzi group from the Cystic Fibrosis Unit at San Raffaele Scientific Institute in Milano, and is funded by the Italian FFC foundation.

The main focus of this project is to investigate the adaptive mechanisms exploited by Pseudomonas aeruginosa during lung infection in people with cystic fibrosis following a highly effective modulator therapy.

This work is in collaboration with Dr. Bragonzi group from the Cystic Fibrosis Unit at San Raffaele Scientific Institute in Milano, and is funded by the Italian FFC foundation.

We are investigating the role of microbiota in pancreatic cancer onset and prognosis through a combination of culture methods and shotgun metagenomics approaches.

This project is in collaboration with Dott. Paiella group in the General and Pancreatic Surgery Unit, the Department of Surgery, Dentistry, Paediatrics and Gynecology, and the Department of Diagnostics and Public Health at the University of Verona.

We are exploring the interactions between human miRNAs expressed in different tissues and Plasmodium spp. UTRs to uncover regulatory networks.

This is a collaboration with Dr. Elena Pomari at IRCCS Ospedale Sacro Cuore Don Calabria.

The aim of the project is to unravel exercise-induced trascriptional dynamics in marathon runners at the single-cell level.

This is part of the RUN for SCIENCE initiative promoted by the department of Neuroscience, Biomedicine and Movement of the University of Verona.

BioVRPi is a GMLab project that focuses on Pi platforms employment in bioinformatics, with particular regards on genomics. The project aims to develop and offer a low-cost, stable, and tested bioinformatic environment for students and researchers involved in genomics and transcriptomics fields.

The main focus of this project is to investigate the adaptive mechanisms exploited by Achromobacter spp. during chronic lung infection in cystic fibrosis patients, and to unravel underlying key processes involved in the onset of a chronic rather than an occasional infection. 

This work is in collaboration with Prof. Lleò group from the Clinical Microbiology section at Università degli Studi di Verona and the Verona CF centre, and is funded by the Italian FFC foundation.

The main objectives of this work are the monitoring of environmental antibiotic resistance reservoirs and the identification of possible new resistance genes variants. This is carried out by analysing Next Generation Sequencing data obtained through single isolates Whole Genome Sequencing and shotgun metagenomics approaches.

This is a collaboration with Prof. Vignaroli group from Università Politecnica delle Marche, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche (IZSUM) and Clinical Microbiology group at Università degli Studi di Verona, and is funded by Fondazione Cariverona.

The aims of this study are to analyse the miRNome of  Strongyloides stercoralis, and to predict potential miRNA target sites in mRNA sequences. 

This is a collaboration with Dr. Elena Pomari at IRCCS Ospedale Sacro Cuore Don Calabria and Dr. Denis Voronin from NIH.