Larry & The Negative Spirit and Shipping: Question - Is shipping with Larry polyamorous by default? The Negative Spirit is always there and it loves to interfere so at the very least it's a sort of unrequested wingman if not more. It would definitely help them on dates by projecting them into each other's minds so they could have a dream date where Larry doesn't have to be in his bandages. It did that for Larry and John when John was dying. Honestly a third partner would probably be accurate for it, although an unconventional one. It's not romantic between Larry and the Negative Spirit but it's still a partner in a way. The Negative Spirit does feel Larry’s romantic feelings for people but it doesn't process emotions the same way, but it considers Larry’s partner(s) its too.
Larry & The Negative Spirit as Parts of Each Other: Their relationship is complicated. They're one but they're not. It's almost the personification of what makes Larry "different" from everyone around him, and he kind of resents it for that (his self-loathing extends to it) but the more he accepts himself the easier their relationship becomes and its main goal is to get Larry to love and accept himself (and other people) and in that way his relationship with the Negative Spirit is like a metaphor for, at first self-hatred, then self-acceptance and self-love (both getting over his severe internalized homophobia and accepting his disabilities).
Larry/The Negative Spirit as a pseudo-romantic relationship: But it's also played a lot like a romantic relationship. A flawed but deep one. They're separate entities. They fight like an old married couple. They are terrible at communicating with each other. They love each other, they hate each other, they're stuck together, they always come back for each other. They're a part of each other. His relationship with the Negative Spirit is the only relationship he's had that he tells John about when John asked him if he had been with anyone else since they were together when they were reunited. Larry and the Negative Spirit actually have a baby together (and it leaves him which honestly is rude of it).
Autism and Social Awkwardness: Larry is definitely socially awkward. He might be autistic, although undiagnosed. All of the autistic characteristics I use for him are definitely apparent in the show, although I might use some specifically autistic terminology for it when they do not do that on the show, which puts in more of an implication of Larry’s autistic characteristics actually being autism. There are other explanations for some of them that could still make sense for his character, but as someone who has been doing a lot of research into autism lately because it seems very likely to me and many of my neurodivergent friends that I might also be on the spectrum, that’s how I’m approaching Larry here (and I am not the only one to interpret him this way): As someone who is potentially autistic writing a character who is similarly potentially autistic.