Publications
Articles, Preprints and Reviews
2023
Daigle SE, Doucet S, Lapierre LR. Ubiquitinated protein levels remain high during ageing in C. elegans. bioRxiv. 2023; 566011
https://www.biorxiv.org/content/10.1101/2023.11.07.566011v1
Lapierre LR. Neuronal HLH-30/TFEB modulates thermoresistance and longevity in C. elegans. Aging. 2023; Oct. 12.
https://doi.org/10.18632/aging.204849
Kumar AV, Mills J, Parker WM, Leitao JA, Rodriguez DI, Daigle S, Ng C, Patel R, Aguilera JL, Johnson JR, Wong SQ, Lapierre LR. Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics and lifespan in C. elegans. iScience. 2023; Sep 16.
https://www.cell.com/iscience/fulltext/S2589-0042(23)02037-0
Wong SQ, Ryan C, Bonal DM, Mills J, Lapierre LR. Neuronal HLH-30/TFEB modulates muscle mitochondria fragmentation to improve thermoresistance in C. elegans. Aging Cell. 2023; Mar. 22:(3)e13741.
https://onlinelibrary.wiley.com/doi/10.1111/acel.13741
2022
de Lima Camillo LP, Lapierre LR, Singh R. A pan-tissue DNA-methylation epigenetic clock based on deep learning. NPJ Aging and Mechanisms of Disease. 2022; Apr. 19.
https://www.nature.com/articles/s41514-022-00085-y
Wong SQ, Ryan C, Lapierre LR. Neuronal HLH-30/TFEB modulates muscle mitochondria fragmentation to improve thermoresistance in C. elegans. bioRxiv. 2022; Apr. 10.
https://www.biorxiv.org/content/10.1101/2022.04.07.487519v1
Kumar AV, Kang T, Thakurta TG, Ng C, Rogers AN, Larsen MR, Lapierre LR. Exportin 1 modulates life span by regulating nucleolar dynamics via autophagy protein LGG-1/GABARAP. Science Advances. 2022; Apr 1;8(13):eabj1604.
https://www.science.org/doi/10.1126/sciadv.abj1604
Lyu YJ, Gao AW, Smith RL, Janssens GE, Panneman DM, Jongejan A, van Weeghel M, Vaz FM, Silvestrini MJ, Lapierre LR, MacInnis AW, Hootkooper RH. Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans. Scientific Reports. 2022; Mar 1;12(1):3350.
https://www.nature.com/articles/s41598-022-07397-9
Kumar AV, Mills J, Lapierre LR. Selective autophagy receptor p62/SQSTM1, a pivotal player in stress and aging. Frontiers in Cell and Developmental Biology. 2022; Feb. 14;10:793328.
https://www.frontiersin.org/articles/10.3389/fcell.2022.793328/full
2021
Kumar AV, Lapierre LR. Location, location, location: subcellular protein partitioning in proteostasis and aging. Biophysical Reviews. 2021; 13:931-941
https://link.springer.com/article/10.1007/s12551-021-00890-x
de Lima Camillo LP, Lapierre LR, Singh R. AltumAge: A pan-tissue DNA-methylation clock based on deep learning. bioRxiv. 2021; Jun 1.
https://www.biorxiv.org/content/10.1101/2021.06.01.446559v1
Kumar AV, Mills J, Parker WM, Leitao JA, Rodriguez DI, Ng C, Patel R, Aguilera JL, Johnson JR, Wong SQ, Lapierre LR. Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics and lifespan in C. elegans. bioRxiv. 2021; Apr 22. https://www.biorxiv.org/content/10.1101/2021.04.22.440991v1
2020
Liu J, Gao AW, Smith RL, Janssens GE, Panneman DM, Jongejan A, van Wheegel M, Vaz FM, Silvestrini MJ, Lapierre LR, MacInnes, AW, Hootkooper RH. Reduced ech-6 expression attenuates fat-induced premature aging in C. elegans. bioRxiv. 2020; Nov 2.
https://www.biorxiv.org/content/10.1101/2020.11.02.364760v1
2019
Wong SQ, Kumar AV, Mills J, Lapierre LR. Autophagy in aging and longevity. Human Genetics. 2019; Mar;139(3):277-90 Full Text Pubmed
Mills J, McConnell E, Leitao J, Lapierre LR. Combined nucleotide and protein extractions in Caenorhabditis elegans. Journal of Visualized Experiments. 2019; Mar 17 (145) Full Text Pubmed
Denzel M, Lapierre LR, Mack HID. Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics. Mechanisms of Ageing and Development. 2019; 177:4-21 Full Text Pubmed
2018
Kumar AV, Thakurta TG, Silvestrini MJ, Johnson JR, Reenan RA, Lapierre LR. Give me a SINE: How Selective Inhibitors of Nuclear Export modulate autophagy and aging. Molecular Cellular Oncology. 2018; 5(5)e1502511 Full Text Pubmed
Silvestrini MJ, Johnson, JR, Kumar AV, Thakurta TG, Blais K, Neill ZA, Marion SW, St. Amand V, Reenan RA, Lapierre LR. Nuclear export inhibition enhances HLH-30/TFEB activity, autophagy and lifespan. Cell Reports. 2018; 23(7):1915-1921 Full Text Pubmed
De Magalhaes Filho CD, Henriquez B, Seah NE, Evans RM, Lapierre LR, Dillin A. Visible light reduces C. elegans longevity. Nature Communications. 2018; 9(1):927. Full Text Pubmed
2016
Seah NE, De Magalhaes Filho CD, Petrashen AP, Henderson HR, Laguer J, Gonzalez J, Dillin A, Hansen M, Lapierre LR. Autophagy-mediated longevity is modulated by lipoprotein biogenesis. Autophagy. 2016 ; 12(2) : 261-72 . Full Text PubMed
Klionsky DJ et al. (1000+ authors) Guidelines for the use and interpretation of assays monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222 Full Text PubMed
2015
Lapierre, LR, Kumsta, C, Sandri, M, Ballabio, A and Hansen, M. Transcriptional and epigenetic regulation of autophagy in aging. Autophagy. 2015; 11 (6) : 867-80 . Full Text PubMed
Zhang H, Chang JT, Guo B, Hansen M, Jia K, Kovács AL, Kumsta C, Lapierre LR, Legouis R, Lin L, Lu Q, Meléndez A, O'Rourke EJ, Sato K, Sato M, Wang X, Wu F. Guidelines for monitoring autophagy in Caenorhabditis elegans. Autophagy. 2015;11(1) 9-27 . Full Text PubMed
2013
Lapierre LR, De Magalhaes Filho CD, McQuary PR, Chu CC, Visvikis O, Chang JT, Gelino S, Ong B, Davis AE, Irazoqui JE, Dillin A, Hansen M. The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Nature Communications 2013; 4 : 2267 . Full Text PubMed
Lapierre LR, Silvestrini MJ, Nuñez L, Ames K, Wong S, Le TT, Hansen M, Meléndez A. Autophagy genes are required for normal lipid levels in C. elegans. Autophagy. 2013; 9 (3) : 278-86 . Full Text PubMed
2012
Lapierre LR, Meléndez A, Hansen M. Autophagy links lipid metabolism to longevity in C. elegans. Autophagy. 2012; 8 (1) : 144-6 . Full Text PubMed
Lapierre LR, Hansen M. Lessons from C. elegans: signaling pathways for longevity. Trends in Endocrinology & Metabolism. 2012; 23 (12) : 637-44 . Full Text PubMed
2011
Lapierre LR, Gelino S, Meléndez A, Hansen M. Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Current Biology. 2011; 21 (18) : 1507-14 . Full Text PubMed
Book Chapters
2020
Wong SQ, Kumar AV, Mills J and Lapierre, LR. Chapter 4. C. elegans to model autophagy-related human disorders. Progress in Molecular Biology and Translational Science. 2020; In Press April 6 Abstract
2016
Nakamura T, Lapierre LR, Hansen M and Lipton S. Chapter 11. The Neurobiology of aging: Free Radical Stress and Metabolic Pathways. BrockleHurst's Textbook of Geriatric Medicine and Gerontology, 8th edition. 2016; 63-69 Full Text