Elizabeth B. Lange, MD, FAAP, attended Smith College as an undergraduate and Pennsylvania State University College of Medicine. She completed her pediatric residency at Rhode Island Hospital/Hasbro Children's Hospital and started practicing pediatrics in 1995.

There's no better way to prepare for the USMLE Step 2 CK and the pediatrics clerkship exam than LANGE: Q&A: Pediatrics. This board-format review offers outstanding coverage of high-yield topics in pediatrics and provides detailed explanations of both correct and incorrect answer choices.


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Cornelia de-Lange syndrome is characterized by distinctive facial dysmorphism, primordial short stature, hirsutism, and upper limb reduction defects that range from subtle phalangeal abnormalities to oligodactyly. Craniofacial features include synophrys, arched eyebrows, long eyelashes, small widely spaced teeth and microcephaly. IQ ranges from between 30 and 102 with an average of 53. Many individuals demonstrate autistic and self-destructive tendencies. It is an autosomal dominant disorder caused by specific gene mutations and occurrence is one in 10,000 to 50,000 children. This is a case report of a 2 1/2-year-old female child with Cornelia de-Lange syndrome phenotype.

CdLS has been characterized by retardation in growth, distinctive facial dysmorphism, primordial short stature, psychomotor delay, behavioural problems, hirsutism and upper limb reduction defects that range from subtle phalangeal abnormalities to oligodactyly.5 e24fc04721

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