Artificial intelligence (AI) has emerged as an indispensable force, propelling oncology into an era of precision medicine. AI's ability to analyze complex datasets quickly and accurately has enabled us to tailor treatments with unprecedented accuracy. By sifting through vast health records, genetic profiles, and molecular data, AI uncovers hidden patterns and connections, guiding clinicians toward optimal therapies for individual patients. We have demonstrated the power of AI in characterizing the genomic heterogeneity of melanoma. We showed that integrating genomic data with known associations between genomic variation and melanoma prognosis can facilitate the identification of genomic features most relevant to patient outcome.