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Goal
To better understand the complex state of the brain pathology, we seek to recapitulate the brain microenvironment that can address changes in physiological activity, cell-cell network, and transcriptome specific to a neurodegenerative disease, traumatic brain injury (TBI), brain cancer, or neuroinflammation.
Towards this end, our research focuses on topics as below.
Research Topics
Experimental and analytical brain model systems
1. Brain barrier models for studying neuro-immune interaction
BBB model for studying ischemic stroke
BCSFB model for studying hydrocephalus
2. Region-specific neural organoids for modeling disorders in the central nervous system
2.1. Synaptic cross-talk between the brain and brain tumor
Recent discovery: glioma forms synapses with neurons
We demonstrated glioma alone is electrically responsive to neurotransmitter-modulating drugs
Investigating the synaptic communication between glioma and neurons
2.2. Choroid plexus dysfunction and iron metabolism
We recently demonstrated ferric iron (Fe3+) induces severe hydrocephalus during intraventricular hemorrhage
Investigating the iron-related water transport dysfunction during hydrocephalus
3. Electric field (E-Field) as a nerve regeneration cue
We previously showed the effect of E-Field on neurite outgrowth is dependent on the developmental stage of a neuron
Determining the role of E-Field in mediating glial cell differentiation and migration
4. Analytical model for a quantitative interpretation of neural connection and network
We previously employed mathematical algorithms to extract the neuronal structures and quantify the morphology from diverse image formats
Currently applying new parameters/algorithms to images to decipher the process underlying how neurites are guided and form networks
Also investigating the correlation of morphological abnormality with transcriptomic changes
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