Publications

Bibliography (links provided)


2018-Present

  1. Xu, R., Li, X., Boreland, A. J., Posyton, A., Kwan, K., Hart, R. P., & Jiang, P. (2020). Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain. Nature communications, 11, 1577. PubMed

  2. Song, Z., Laureano, A. S., Patel, K., Yip, S., Jadali, A., & Kwan, K. Y. (2019). Single-Cell Fluorescence Analysis of Pseudotemporal Ordered Cells Provides Protein Expression Dynamics for Neuronal Differentiation. Frontiers in cell and developmental biology, 7, 87. PubMed

  3. Rathnam, C., Chueng, S. D., Ying, Y. M., Lee, K. B., & Kwan, K. Y. (2019). Developments in Bio-Inspired Nanomaterials for Therapeutic Delivery to Treat Hearing Loss. Frontiers in cellular neuroscience, 13, 493. PubMed

  4. Chen, J. Y., Parekh, M., Seliman, H., Bakshinskaya, D., Dai, W., Kwan, K., Chen, K. Y., & Liu, A. Y. C. (2018). Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction. The Journal of biological chemistry, 293, 15581-15593. PubMed

  5. Sun, N., Nasello, C., Deng, L., Wang, N., Zhang, Y., Xu, Z., Song, Z., Kwan, K., King, R. A., Pang, Z. P., Xing, J., Heiman, G. A., & Tischfield, J. A. (2018). The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family. Molecular psychiatry, 23, 1487-1495. PubMed


2017

  1. Song Z., Jadali A., Fritzsch B., Kwan K.Y. (2017) Neurog1 Promotes Proliferation by Regulating CDK2, Stem Cell Reports

  2. Ebeid M., Sripal P., Pecka J., Beisel K., Kwan K.Y., Soukup G, (2017) Transcriptome-Wide Comparison of the Impact of Atoh1 and miR-183 Family on Pluripotent Stem Cells and Multipotent Otic Progenitor Cells, PLOS One

  3. Jadali A., Ying Y.M., Kwan K.Y. (2017) Activation of CHK1 in Supporting Cells Indirectly Promotes Hair Cell Survival, Frontiers in Cellular and Developmental Biology


2016

  1. Zappia K.J., O’Hara C.L., Moehring F., Kwan K.Y., Stucky C.L.(2016) Sensory neuron-specific deletion of TRPA1 results in mechanical cutaneous sensory deficits, eNeuro

  2. Kwan K.Y. (2016) Single-Cell Transcriptome Analysis of Developing and Regenerating Spiral Ganglion Neurons ,Current Pharmacology Report

  3. Li Y., Tzatzalos E., Kwan K.Y., Grumet M., Cai L. (2016) Transcriptional Regulation of Notch1 Expression by Nkx6.1 in Neural Stem/Progenitor Cells during Ventral Spinal Cord Development. Sci. Rep. 6:38665.

  4. Vogl C., Panou I., Yamanbaeva G., Wichmann C., Mangosing S.J., Vilardi F., Indzhykulian A.A., Pangršič T., Santarelli R., Rodriguez-Ballesteros M., Weber T., Jung S., Cardenas E., Wu X., Wojcik S.M., Kwan K.Y., Del Castillo I., Schwappach B., Strenzke N., Corey D.P., Lin S.Y., Moser T. (2016) Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing. EMBO J. Dec 1;35(23):2536-2552.

  5. Norris A., Tammineni P., Wang S., Gerdes J., Murr A., Kwan K.Y., Cai Q., Grant B.D. (2016) SNX-1 and RME-8 oppose the assembly of HGRS-1/ESCRT-0 degradative microdomains on endosomes. Proc Natl Acad Sci U S A. Jan 17;114(3):E307-E316. doi: 10.1073/pnas.1612730114.

  6. Kwan K. Y. (2016) Detection of Murine TRPA1 Transcripts in Keratinocytes J Skin Stem Cell doi: 10.17795/jssc.32521.

  7. Jadali, A., and Kwan K.Y. (2016) Activation of PI3K Signaling Prevents Aminoglycoside-Induced Hair Cell Death in the Murine Cochlea Biology Open doi: 10.1242/bio.016758.

  8. Jadali, A., Song, Z.*, Laureano, A.*, Toro-Ramos, A., Kwan, K.Y. (2016) Initiating Differentiation in Immortalized Multipotent Otic Progenitors Journal of Visualized Experiments 107; doi: 10.3791/53692.


2015

  1. Patel S., Chueng S-T D., Yin P.T., Dardir K., Song Z., Pasquale N., Kwan K.Y., Sugiyama H., Lee K.B. (2015) Induction of Stem-Cell-Derived Functional Neurons by NanoScript-Based Gene Repression Angewandte Chemie Oct5 54(41):11983–11988 doi: 10.1002/anie.201504902.

  2. Shen J., Scheffer D.I., Kwan K.Y., Corey DP. (2015) SHIELD: an integrative gene expression database for inner ear research. Database (Oxford). 2015 Jul 24;2015:bav071. doi:10.1093/database/bav071.

  3. Kwan K.Y., Shen J., Corey D. P. (2015) Multipotent Inner Ear Progenitor Cells Reveal a Switch from Self-Renewal to Differentiation Stem Cell Reports Epub Dec 10. pii: S2213-6711(14)00351-8. doi: 10.1016/j.stemcr.2014.11.001.


Past Publications

  1. Shigetomi, E., Tong, X., Kwan K.Y., Corey D.P., Khakh, B.S. (2011) TRPA1 mediated microdomains regulate astrocyte resting calcium levels and inhibitory synapse efficacy via GAT-3. Nat. Neurosci. 15(1):70-80.

  2. Kwan, K. Y.*, Glaser, J.*, Rice, F. L., Corey. D. P., Stucky C. (2009) TRPA1 modulates mechanosensation through keratinocytes. J. Neurosci. 29:4808-19.

  3. Karashima Y., Talavera, K., Everaerts W., Janssens A., Kwan K. Y., Vennekens R., Nilius B., Voets T. (2009) TRPA1 acts as a cold sensor in vitro and in vivo. Proc. Natl. Acad. Sci. U.S.A. 106:1273-8. PMC2633575.

  4. Brierley S.M., Hughes P.A., Page A.J., Kwan K.Y., Martin C.M., O'Donnell T.A., Cooper N.J., Harrington A.M., Adam B., Liebregts T., Holtmann G., Corey D.P., Rychkov G.Y., Blackshaw L.A. (2009) The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology 137:2084-2095.

  5. Mohanty S., Town T., Yagi T., Scheidig C., Kwan K. Y., Allore H. G., Flavell R. A., Shaw A. C. (2008) Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3β. Proc. Natl. Acad. Sci. U.S.A. 105:6063-8.

  6. Macpherson L. J.*, Xiao B.*, Kwan K. Y.*, Petrus M, Cravatt B. F., Corey, D. P., Patapoutian, A. (2007) An ion channel essential for sensing chemical damage. J Neurosci. 27:11412-5.

  7. Kwan K. Y., Greenwald R. J., Mohanty S., Sharpe A. H., Shaw, A. C., Wang, J. C. (2007) Development of autoimmunity in mice lacking DNA topoisomerase 3β. Proc. Natl. Acad. Sci. U.S.A. 104: 9242-7.

  8. Kwan K. Y., Allchorne A. J., Vollrath M. A., Christensen A. P., Zhang D-. S., Woolf C. J., Corey D. P. (2006) TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron 50:277-89.

  9. Corey D. P.*, Garcia-Añoveros J.*, Holt J. R.*, Kwan K. Y.*, Lin S.-Y.*, Vollrath, M. A.*, Amalfitano A., Cheung E. L.-M., Derfler B. H., Duggan A., Géléoc G. S. G., Gray P. A., Hoffman M. P., Rehm H. L., Tamasauskas D., Zhang D.-S. (2004) TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature 432:723-30. *authors contributed equally

  10. Kwan, K. Y., Moens, P. B., Wang, J. C. (2003) Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase IIIβ. Proc Natl Acad Sci USA 100:2526-31.

  11. Kwan, K. Y., Wang, J.C. (2001) Mice lacking DNA topoisomerase IIIβ develop to maturity but show a reduced mean lifespan. Proc Natl Acad Sci USA 98:5717-21.

  12. Polaczek, P., Kwan, K., Campbell, J. L. (1998) GATC motifs may alter the conformation of DNA depending on sequence context and N6-adenine methylation status: possible implications for DNA-protein recognition. Mol Gen Genet. 258:488-93.

  13. Polaczek, P., Kwan, K., Campbell, J. L. (1998) Unwinding of the Escherichia coli origin of replication (oriC) can occur in the absence of initiation proteins but is stabilized by DnaA and histone-like proteins IHF or HU. Plasmid 39:77-83.

  14. Polaczek, P., Kwan K., Liberlies D. A., Campbell J. L. (1997) Role of architectural elements in combinatorial regulation of initiation of DNA replication in Escherichia coli. Mol Microbiol. 26:261-75.