Publication

• Lee J, Cho E and Jo YS (2026) The medial prefrontal cortex is required for prospective navigation in spatial sequential memory. Front. Behav. Neurosci. 20:1930201. 

https://doi.org/10.3389/fnbeh.2026.1930201

• Pyeon, G. H., Lim, J., Lee, J., Lee, J., Lee, H. J., & Jo, Y. S. (2026). Noninvasive tFUS stimulation of the parabrachial nucleus suppresses lever pressing during extinction of cocaine self-administration through aversive circuit engagement. Brain Stimulation, 19(5), 103197.

https://doi.org/10.1016/j.brs.2026.103197

• Lee, H. H., Han, E., & Jo, Y. S. (2026). CGRP inhibition in the PBN shifts defensive strategy from freezing to active avoidance in a platform-based active avoidance paradigm. npj Science of Learning. 

https://doi.org/10.1038/s41539-026-00453-3

• Jo, Y. S., Kong, M., Sethi, E., Pyeon, G. H., & Zweifel, L. S. (2026). A neural circuit basis for reward-induced suppression of fear generalization and enhancement of fear extinction. Proceedings of the National Academy of Sciences of the United States of America, 123(4), e2522768123.

https://doi.org/10.1073/pnas.2522768123

• Pyeon, G. H., Cho, H., Chung, B. M., Choi, J.-S., & Jo, Y. S. (2025). Parabrachial CGRP neurons modulate active defensive behavior under a naturalistic threat. eLife, 13, e101523. 

https://doi.org/10.7554/eLife.101523 

• Jo, Y. S., Pyeon, G. H., & Mizumori, S. J. Y. (2024). A role for the midbrain reticular formation in delay-based decision making. Frontiers in Systems Neuroscience, 18, 1481585. 

https://doi.org/10.3389/fnsys.2024.1481585

• Pyeon, G. H., Kim, J.-H., Choi, J.-S., & Jo, Y. S. (2024). Activation of CGRP neurons in the parabrachial nucleus suppresses addictive behavior. Proceedings of the National Academy of Sciences of the United States of America, 121, e2401929121.

https://doi.org/10.1073/pnas.2401929121

• Park, E. H., Jo, Y. S., Kim, E. J., Park, E. H., Lee, K. J., Rhyu, I. J., Kim, H. T., & Choi, J.-S. (2024). Heterogenous effect of early adulthood stress on cognitive aging and synaptic function in the dentate gyrus. Frontiers in Molecular Neuroscience, 17, 1344141.

https://doi.org/10.3389/fnmol.2024.1344141

• Lee, J., Kim, Y. E., Lim, J., Jo, Y., Lee, H. J., Jo, Y. S., & Choi, J.-S. (2024). Transcranial focused ultrasound stimulation in the infralimbic cortex facilitates extinction of conditioned fear in rats. Brain Stimulation, 17. 

https://doi.org/10.1016/j.brs.2024.03.013

• Pyeon, G. H., Lee, J., Jo, Y. S., & Choi, J.-S. (2023). Conditioned flight response in female rats to naturalistic threat is estrous-cycle dependent. Scientific Reports, 13, 20988.

https://doi.org/10.1038/s41598-023-47591-x Nature

• Yang, S. H., Yang, E., Lee, J., Kim, J. Y., Yoo, H., Park, H. S., Jung, J. T., Lee, D., Chun, S., Jo, Y. S., Pyeon, G. H., Park, J.-Y., Lee, H. W., & Kim, H. (2023). Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice. Nature Communications, 14, 2435. 

https://doi.org/10.1038/s41467-023-38180-7 Nature

• Juarez, B., Kong, M.-S., Jo, Y. S., Elum, J. E., Yee, J. X., Ng-Evans, S., Cline, M., Hunker, A. C., Quinlan, M. A., Baird, M. A., Elerding, A. J., Johnson, M., Ban, D., Mendez, A., Goodwin, N. L., Soden, M. E., & Zweifel, L. S. (2023). Temporal scaling of dopamine neuron firing and dopamine release by distinct ion channels shape behavior. Science Advances, 9(32), eadg8869. 

https://doi.org/10.1126/sciadv.adg8869

• Kim, S., Kim, S.-W., Bui, M. A. T., Kim, Y., Kim, M., Park, J.-C., Kim, N.-H., Pyeon, G. H., Jo, Y. S., Jang, J., Koh, H.-Y., Jeong, C.-H., Kang, M., Kang, H. J., Lee, Y.-W., Stockmeier, C. A., Seong, J. K., Woo, D. H., Han, J.-S., & Kim, Y.-S. (2022). SELENBP1 overexpression in the prefrontal cortex underlies negative symptoms of schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 119(51), e2203711119.

https://doi.org/10.1073/pnas.2203711119 PubMed

• Fellinger, L., Jo, Y. S., Hunker, A. C., Soden, M. E., Elum, J., Juarez, B., & Zweifel, L. S. (2021). A midbrain dynorphin circuit promotes threat generalization. Current Biology, 31(19), 4388–4396.e5.

https://doi.org/10.1016/j.cub.2021.07.047

2020

• Jo, Y. S., Namboodiri, V. M. K., Stuber, G. D., & Zweifel, L. S. (2020). Persistent activation of central amygdala CRF neurons helps drive the immediate fear extinction deficit. Nature Communications, 11, 422. https://doi.org/10.1038/s41467-020-14393-y PubMed

• Heymann, G., Jo, Y. S., Reichard, K. L., McFarland, N., Chavkin, C., Palmiter, R. D., Soden, M. E., & Zweifel, L. S. (2020). Synergy of distinct dopamine projection populations in behavioral reinforcement. Neuron, 105(5), 909–920.e5. https://doi.org/10.1016/j.neuron.2019.11.024 PubMed

2018

• Jo, Y. S., Heymann, G., & Zweifel, L. S. (2018). Dopamine neurons reflect the uncertainty in fear generalization. Neuron, 100(4), 916–925.e3. https://doi.org/10.1016/j.neuron.2018.09.028 ScienceDirect

2017

• Song, M., Jo, Y. S., Lee, Y.-K., & Choi, J.-S. (2017). Lesions of the lateral habenula facilitate active avoidance learning and threat extinction. Behavioural Brain Research, 318, 12–17. https://doi.org/10.1016/j.bbr.2016.10.013 ScienceDirect

• Gore, B. B., Miller, S. M., Jo, Y. S., Baird, M. A., Hoon, M., Sanford, C. A., Hunker, A., Lu, W., Wong, R. O., & Zweifel, L. S. (2017). Roundabout receptor 2 maintains inhibitory control of the adult midbrain. eLife, 6, e23858. https://doi.org/10.7554/eLife.23858 eLife

2016

• Jo, Y. S., & Mizumori, S. J. Y. (2016). Prefrontal regulation of neuronal activity in the ventral tegmental area. Cerebral Cortex, 26(10), 4057–4068. https://doi.org/10.1093/cercor/bhv215 PubMed

2015

• Redila, V., Kinzel, C., Jo, Y. S., Puryear, C. B., & Mizumori, S. J. Y. (2015). A role for the lateral dorsal tegmentum in memory and decision neural circuitry. Neurobiology of Learning and Memory, 117, 93–108. https://doi.org/10.1016/j.nlm.2014.05.009 PubMed

2014

• Jo, Y. S., & Choi, J.-S. (2014). Memory retrieval in response to partial cues requires NMDA receptor-dependent neurotransmission in the medial prefrontal cortex. Neurobiology of Learning and Memory, 109, 20–26. https://doi.org/10.1016/j.nlm.2013.11.004 PubMed

2013

• Jo, Y. S., Lee, J., & Mizumori, S. J. Y. (2013). Effects of prefrontal cortical inactivation on neural activity in the ventral tegmental area. Journal of Neuroscience, 33(19), 8159–8171. https://doi.org/10.1523/JNEUROSCI.0118-13.2013 PubMed

• Mizumori, S. J. Y., & Jo, Y. S. (2013). Homeostatic regulation of memory systems and adaptive decisions. Hippocampus, 23(11), 1103–1124. https://doi.org/10.1002/hipo.22176 PubMed Central (PMC)

2012

• Yoon, K.-J., Lee, H.-R., Jo, Y. S., An, K., Jung, S.-Y., Jeong, M.-W., Kwon, S.-K., Kim, N.-S., Jeong, H.-W., Ahn, S.-H., Kim, K.-T., Lee, K., Kim, E., Kim, J.-H., Choi, J.-S., Kaang, B.-K., & Kong, Y.-Y. (2012). Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway. Molecular Brain, 5, 40. https://doi.org/10.1186/1756-6606-5-40 PubMed

2011

• Norton, A. B. W., Jo, Y. S., Clark, E. W., Taylor, C. A., & Mizumori, S. J. Y. (2011). Independent neural coding of reward and movement by pedunculopontine tegmental nucleus neurons in freely navigating rats. European Journal of Neuroscience, 33(10), 1885–1896. https://doi.org/10.1111/j.1460-9568.2011.07649.x PubMed Central (PMC)

2010

• Jo, Y. S., & Lee, I. (2010). Disconnection of the hippocampal–perirhinal cortical circuits severely disrupts object–place paired associative memory. Journal of Neuroscience, 30(29), 9850–9858. https://doi.org/10.1523/JNEUROSCI.1580-10.2010 PubMed

• Kim, S. C., Jo, Y. S., Kim, I. H., Kim, H., & Choi, J.-S. (2010). Lack of medial prefrontal cortex activation underlies the immediate extinction deficit. Journal of Neuroscience, 30(3), 832–837. https://doi.org/10.1523/JNEUROSCI.4145-09.2010 PubMed

• Jo, Y. S., & Lee, I. (2010). Perirhinal cortex is necessary for acquiring, but not for retrieving object–place paired association. Learning & Memory, 17(2), 97–103. https://doi.org/10.1101/lm.1620410 PubMed Central (PMC)

• Lee, J., Jo, Y. S., Sung, Y. H., Hwang, I. K., Kim, H., Kim, S.-Y., Yi, S. S., Choi, J.-S., Sun, W., Seong, J. K., & Lee, H.-W. (2010). Telomerase deficiency affects normal brain functions in mice. Neurochemical Research, 35(2), 211–218. https://doi.org/10.1007/s11064-009-0044-3 PubMed

2009

• Kim, I. H., Park, S. K., Hong, S. T., Jo, Y. S., Kim, E. J., Park, E. H., Han, S. B., Shin, H.-S., Sun, W., Kim, H. T., Soderling, S. H., & Kim, H. (2009). Inositol 1,4,5-trisphosphate 3-kinase A functions as a scaffold for synaptic Rac signaling. Journal of Neuroscience, 29(44), 14039–14049. https://doi.org/10.1523/JNEUROSCI.2483-09.2009 PubMed

2007

• Jo, Y. S., Park, E. H., Kim, I. H., Park, S. K., Kim, H., Kim, H. T., & Choi, J.-S. (2007). The medial prefrontal cortex is involved in spatial memory retrieval under partial-cue conditions. Journal of Neuroscience, 27(49), 13567–13578. https://doi.org/10.1523/JNEUROSCI.3589-07.2007