As various types of diseases have been discovered and identified, development of diagnostic and therapeutic methods is becoming increasingly important. The first step for this is to understand the biological phenomena and disease in a molecular level and to design (1) efficient analytical tools monitoring biomolecular interactions and (2) chemical tools regulating biological actions. To achieve these goals, we create novel functional biomolecules, obtained from chemical modification of natural biomolecules, and develop "functional biomolecular systems" that can be utilized in the field of biology, chemical biology, bioorganic chemistry, and medicinal chemistry.
Templated chemistry has been achieved due to the enhanced local concentration of reactants arising from attractive interactions between biomolecules. Through this unique reaction, several biomolecular operations, such as synthesis, cleavage, and transformation, can be conducted. Based on these operations, we develop biomolecular circuits that can be employed for important diagnostic and therapeutic applications, including biomolecule sensing, site-specific functionalization of biomolecules, bioactive molecule (drug) release, and the regulation of biological processes.
References
[1] Chem. Commun. 2022, 58, 13743-13746.
[2] Bioconjugate Chem. 2023, ASAP.