Embedded Files
Selected publications
The EMBO Journal
Volume 44, Issue 3, 3 February 2025
This cover highlights the article A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease by Kyungtae Lim, Eimear N. Rutherford, Emma L. Rawlins, Jennifer A. Dickens and colleagues. Mature, genetically-manipulable and cryo-preservable human alveolar type-2 cell organoids were derived from foetal lungs and used to explore the mechanisms of surfactant processing in pulmonary disease.
Scientific image by Kyungtae Lim
*Kyungtae Lim, *Eimear N. Rutherford, Livia Delpiano, Peng He, Weimin Lin, Dawei Sun, Dick J. H. Van den Boomen, James R. Edgar, Jae Hak Bang, Alexander Predeus, Sarah A. Teichmann, John C. Marioni, Lydia E. Matesic, Joo-Hyeon Lee, Paul J. Lehner, Stefan J. Marciniak, Emma L. Rawlins and Jennifer A. Dickens. A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease. The EMBO Journal Jan 15 2025; doi: https://doi.org/10.1038/s44318-024-00328-6
*Kyungtae Lim and *Emma L. Rawlins. Protocol for the derivation and alveolar type 2 differentiation of late-stage lung tip progenitors from the developing human lungs. Star Protocols July 19, 2024. doi: 10.1016/j.xpro.2024.103201 *Correspondence
Kyungtae Lim, Alex P.A. Donovan, Walfred Tang, Dawei Sun, Peng He, J. Patrick Pett, Sarah A. Teichmann, John C. Marioni, Kerstin B. Meyer, Andrea H. Brand and Emma L. Rawlins. Organoid modelling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease. Cell Stem Cell Volume 30, Issue 1, Pages 20-37.e9 Jan 05 2023; doi: https://doi.org/10.1016/j.stem.2022.11.013
- This paper and Peng, Lim, Sun et al. (Cell 2022; below) had been highlighted together in Preview in Cell Stem Cell, “Empowering human lung development” (https://doi.org/10.1016/j.stem.2022.12.012)
*Peng He, *Kyungtae Lim, *Dawei Sun, Jan Patrick Pett, Quitz Jeng, Krzysztof Polanski, Ziqi Dong, Liam Bolt, Laura Richardson, Lira Mamanova, Monika Dabrowska, Anna Wilbrey-Clark, Elo Madissoon, Zewen Kelvin Tuong, Emma Dann, Chenqu Suo, Goh Kai’En, Xiaoling He, Roger Barker, Sarah A Teichmann, John C. Marioni, Kerstin B Meyer, Emma L Rawlins. A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates. Cell Volume 185, Issue 25, Pages 4841-4860.e25, 8 Dec 2022; https://doi.org/10.1016/j.cell.2022.11.005
Dawei Sun, Oriol Llora Batlle, Jelle van den Ameele, John C. Thomas, Peng He, Kyungtae Lim, Walfred Tang, Chufan Xu, Kerstin B. Meyer, Sarah A. Teichmann, John C. Marioni, Stephen P. Jackson, Andrea H. Brand, and Emma L. Rawlins. SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling. The EMBO Journal 2022 e111338; https://doi.org/10.15252/embj.2022111338.
Dawei Sun, Lewis Evans, Francesca Perrone, Vanesa Sokleva, Kyungtae Lim, Saba Rezakhani, Matthias Lutolf, Matthias Zilbauer, Emma L Rawlins. A functional genetic toolbox for human tissue-derived organoids. Elife 2021 Oct 6;10:e67886; https://doi.org/10.7554/eLife.67886
Christoph Muus, Malte D Luecken, Gökcen Eraslan, … Kyungtae Lim, …NHLBI LungMap Consortium; Human Cell Atlas Lung Biological Network. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nature Medicine 2021 Mar;27(3):546-559; https://doi.org/10.1038/s41591-020-01227-z.
Other publications
Josephine L. Barnes, Peng He, Masahiro Yoshida, Kaylee B. Worlock, Rik G.H. Lindeboom, Chenqu Suo, J. Patrick Pett, Anna Wilbrey-Clark, Emma Dann, Lira Mamanova, Laura Richardson, Krzysztof Polanski, Amanda J. Oliver, Adam Pennycuick, Jessica Allen-Hyttinen, Iván T. Herczeg, Romina Arzili, Robert E. Hynds, Vitor H. Teixeira, Muzlifah Haniffa, Kyungtae Lim, Dawei Sun, Emma L. Rawlins, Amanda J. Oliver, Paul A. Lyons, John C. Marioni, Christiana Ruhrberg, Zewen Kelvin Tuong, Menna R. Clatworthy, James L. Reading, Sam M. Janes, Sarah A. Teichmann, Kerstin B. Meyer & Marko Z. Nikolić. Early human lung immune cell development and its role in epithelial cell fate. Science Immunology 2023 Dec 15. https://doi.org/10.1126/sciimmunol.adf9988
*Kyungtae Lim, *Jonghun Kim, *Seon In Hwang, Ludi Zhang, Heonjong Han, Dasom Bae, Kee-Pyo Kim, Yi-Ping Hu, Hans R Schöler, Insuk Lee, Lijian Hui, Dong Wook Han. Direct conversion of mouse fibroblasts into cholangiocyte progenitor cells. Stem Cell Reports Volume 10, Issue 5, 8 May 2018, Pages 1522-1536; https://doi.org/10.1016/j.stemcr.2018.03.002
Sung Min Kim, Jong-Wan Kim, Tae Hwan Kwak, Sang Woong Park, Kee-Pyo Kim, Hyunji Park, Kyungtae Lim, Kyuree Kang, Jonghun Kim, Ji Hun Yang, Heonjong Han, Insuk Lee, Jung Keun Hyun, Young Min Bae, Hans R Schöler, Hoon Taek Lee, Dong Wook Han. Generation of integration-free Induced neural stem cells from mouse fibroblasts. Journal of Biological Chemistry 2016 May 4. https://doi.org/10.1074/jbc.M115.713578
*Kyungtae Lim, Seung Chan Lee, Yimeng Gao, Kee Pyo Kim, Guangqi Song, Su Yeon An, Kenjiro Adachi, Yu Jin Jang, Jonghun Kim, Kyoung Jin Oh, Tae Hwan Kwak, Seon In Hwang, Jueng Soo You, Kinarm Ko, Seung Hoi Koo, Amar Deep Sharma, Jong Hoon Kim, Lijian Hui, Tobias Cantz, Hans R. Schöler, Dong Wook Han. Small molecules facilitate single factor-mediated hepatic reprogramming. Cell Reports Volume 15, Issue 4, 26 April 2016, Pages 814-829. https://doi.org/10.1016/j.celrep.2016.03.071 (PhD thesis)
*Sung Min Kim, *Kyungtae Lim, *Tae Hwan Kwak, Seung Chan Lee, Jung Hyun Im, Sai Hali, Seon In Hwang, Dajeong Kim, Jeongho Hwang, Kee-Pyo Kim, Hak-Jae Chung, Jeong Beom Kim, Kinarm Ko, Hyung-Min Chung, Hoon Taek Lee, Hans R Schöler, Dong Wook Han. Induced neural stem cells from distinct genetic backgrounds exhibit different reprogramming status. Stem Cell Research 2016 Mar;16(2):460-8. https://doi.org/10.1016/j.scr.2016.02.025
Jonghun Kim, Kee-Pyo Kim, Kyungtae Lim, Seung Chan Lee, Juyong Yoon, Guangqi Song, Seon In Hwang, Hans R. Schöler, Tobias Cantz, Dong Wook Han. Generation of integration-free induced hepatocyte-like cells from mouse fibroblasts. Scientific Reports 2015 Oct 27;5:15706. https://doi.org/10.1038/srep15706
Jin Young Hong, Sung Ho Lee, Seung Chan Lee, Jong-Wan Kim, Kee-Pyo Kim, Sung Min Kim, Natalia Tapia, Kyungtae Lim, Jonghun Kim, Hong-Sun Ahn, Kinarm Ko, Chan Young Shin, Hoon Taek Lee, Hans R Schöler, Jung Keun Hyun, Dong Wook Han. Therapeutic Potential of induced neural stem cells for spinal cord injury. Journal of Biological Chemistry 2014 Nov 21;289(47):32512-25. https://doi.org/10.1074/jbc.M114.588871
Dong Wook Han, Natalia Tapia, Marcos J Araúzo-Bravo, Kyungtae Lim, Kee Pyo Kim, Kinarm Ko, Hoon Taek Lee, Hans R Schöler. Sox2 level is a determinant of cellular reprogramming potential. PLoS One 2013 Jun 18;8(6):e67594. https://doi.org/10.1371/journal.pone.0067594
Kyungtae Lim, Mukesh Kumar Gupta, Sung Ho Lee, Yoon Hee Jung, Dong Wook Han, Hoon Taek Lee. Possible Involvement of Wnt/beta-catenin signaling pathway in hatching and trophectoderm differentiation of pig blastocysts. Theriogenology 2013 Jan 15;79(2):284-90. https://doi.org/10.1016/j.theriogenology.2012.08.018
Sang Jun Uhm, Mukesh Kumar Gupta, Ziban Chandra Das, Kyungtae Lim, Ji Hoon Yang, Hoon Taek Lee. Effect of 3-hydroxyflavone on pig embryos produced by parthenogenesis or somatic cell nuclear transfer. Reproductive toxicology 2011 Feb;31(2):231-8. https://doi.org/10.1016/j.reprotox.2010.11.007
Reviews
*Sun Kyung Kim, *Eunho Sung, Kyungtae Lim. Recent advances and applications of human lung alveolar organoids. Molecules and Cells 2024 Volume 47, Issue 12, 100140. https://doi.org/10.1016/j.mocell.2024.100140
Kyungtae Lim, Mi-Ok Lee, Jinwook Choi, Jung-Hyun Kim, Eun-Mi Kim, Chang Gyu Woo, Chaeuk Chung, Yong-Hee Cho, Seok-Ho Hong, Young-Jae Cho, Sun-Ju Ahn. Guidelines for manufacturing and application of organoids: Lung. International Journal of Stem Cells 2024;17:147-157. https://doi.org/10.15283/ijsc24041
Page updated
Google Sites
Report abuse