Research Experience

Projects :

(Last update April 2016)

Ongoing:

Computational dynamic study on drug efflux mechanism and ATP coupled reaction of P-Glycoprotein. (January 2015 - Present):

This project running under supervision of Dr. D. V. Singh (Assistant Professor, Bioinformatics), Central University of South Bihar, India.

P-glycoprotein is known as multidrug resistance protein 1 (MDR1). It is extensively distributed and expressed in the intestinal epithelium and it pumps xenobiotics back into the intestinal lumen, in liver cells which renders these cancers multi-drug resistant.
It mostly found in two states, such as close and open. The ATP is attached to the nucleotide binding region(NBD) and the opening of transmembrane domains efflux the drugs from the cell.
Here we are interest to investigate this efflux mechanism through targeted molecular dynamics, by which we can able to understand the clear picture of multi drug resistance.

In silico prediction of a potential drug target for protein stp1 in Staphylococcus aureus (September 2015 - Present ) :

This project running under supervision of Dr. D. V. Singh (Assistant Professor, Bioinformatics)

Staphylococcus aureus is one of the most common causes of hospital- and community-acquired infections, and is associated with various skin, blood stream infections.
For more than four decades, vancomycin has been the primary treatment for infections caused by Staphylococcus aureus as well as other gram-positive bacterial infections.
More recently with high-level vancomycin resistance been described in the clinical literatures and recently it was not in use as drug for S. aureus infection.
This cause a challenge due to the limited number of bacterial-specific drug targets available for due conservation with the human host and limited therapeutic options.

Collaboration:

Study of protein folding in the presence of hexyltriethylammonium bromide: an experimental and MD simulation study (May 2016 - Present) :

This project running in collaboration with Dr. Harekrushna Sahoo, Asst. Professor, Dept. of Chemistry, National Institute of Technology (NIT), Raurkela, India. In silico modelling and molecular dynamics simulation studies of thiazolidine based PTP1B inhibitors (August 2015 - Present) :

This project running in collaboration with Dr. Manoj Kumar from University Institute of Pharmaceutical Sciences, Punjab University and Dr. D. V. Singh (Asst. Professor, Bioinformatics), Central University of South Bihar, India.

Summer internship work at IISER, Pune:

Computational Study of Protein-DNA Interaction :

This project done under Dr. Arnab Mukherjee (Assistant Professor, Chemistry), Indian Institute of Science Education and Research(IISER), Pune. The DNA kinking is shown when DNA-protein interaction occurs and it lead to sudden change in roll angle as a particular base pair and giving rise to a particular curvature of its helical axis.
The formation of kink is unfavorable for DNA, hence it needs any other interaction like protein or ions to form kink. It's believed that the stabilization of DNA comes from intercalating amino acids.
In the absence of intercalation kink can also form by disruption of base pairing. Hence the clear picture of kinking still not reveal and I'm still working on it to find out it's cause by computational dynamic study (meta-dynamics / polarizable force field).

Completed:

The role of anti-genotoxic properties in Vitis vinifera on Drosophila development which is retarded by the Sodium Nitrite and Nitrate as a potent genotoxicant : This project done under Dr. Ashim Kumar Basak (HOD Molecular Biology) at IGE, Kolkata.
The Biodiversity of Bamboo at Madhya Pradesh, India : This project done under Dr. Sudipa Chakravarty (HOD Genetics) at IGE, Kolkata, India.
Polyethylene(LDPE) biodegradation (September - December 2011) : This project done under Dr. Paromita Bhattacharya (HOD Microbiology) at IGE, Kolkata.
Biodiesel Production (September 2009 - November 2010) : I extracted biodiesel from Pongemia & from some algae species.