Publication
NanoDDS for Brain Drug Delivery
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Research overview
Research overview
NanoDDS for Brain Drug Delivery
Of our research interests are various drug delivery systems,
in particular, clinically applicable delivery systems of
nucleic acid therapeutics (pDNA, asODN, siRNA), using nanoparticular carrier systems of lipids,
polymers, and lipid-polymer hybrid systems, capable of targeting specific tissues, in particular,
brain microvessels and/or intracellular organelles such as mitochondria or nuclei.
Understanding the intracellular and extracellular fate of the nanocarreier systems using various in vitro
and in vivo imaging techniques is also of our interest.
We are well-equipped and well-financed with proven records of productivity.
Publication
Publication
2025.09
2025.09
Grueneberg Ganglion: An Unexplored Site for Intranasal Drug Delivery in Alzheimer’s Disease
ACS Chemical Neuroscience
2024.08
2024.08
Journal of Photochemistry and Photobiology A: Chemistry
2024.04
2024.04
International Journal of Biological Macromolecules
2023.09
2023.09
Subcutaneous injection sites impact brain uptake of blood-brain barrier impermeable paclitaxel
Journal of Pharmaceutical Investigation
2023.05
2023.05
Piezocatalytic 2D WS2 Nanosheets for Ultrasound‐Triggered and Mitochondria‐Targeted Piezodynamic Cancer Therapy Synergized with Energy Metabolism‐Targeted Chemotherapy
Advanced Materials
2023.03
2023.03
Bioengineering & Translational Medicine
2023.02
2023.02
Mitochondria-targeting sonosensitizer-loaded extracellular vesicles for chemo-sonodynamic therapy
Journal of Controlled Release
2023.02
2023.02
Why mRNA-ionizable LNPs formulations are so short-lived: causes and way-out
Expert Opinion on Drug Delivery
2023.01
2023.01
Expert Opinion on Drug Delivery
2022.05
2022.05
Chemical Engineering Journal
2022.04
2022.04
Extracellular vesicles with high dual drug loading for safe and efficient combination chemo-phototherapy
BIOMATERIALS SCIENCE
2022.01
2022.01
Engineered extracellular vesicle-based sonotheranostics for dual stimuli-sensitive drug release and photoacoustic imaging-guided chemo-sonodynamic cancer therapy
Theranostics
2021.11
2021.11
Temperature and pH-responsive in situ hydrogels of gelatin derivatives to prevent the reoccurrence of brain tumor
BIOMEDICINE & PHARMACOTHERAPY
2021.06
2021.06
Safe and Targeted Sonodynamic Cancer Therapy Using Biocompatible Exosome-Based Nanosonosensitizers
ACS applied materials & interfaces
2020.11
2020.11
Lipid Nanoparticles Improve the Uptake of alpha-Asarone Into the Brain Parenchyma: Formulation, Characterization, In Vivo Pharmacokinetics, and Brain Delivery
AAPS PharmSciTech
2020.04
2020.04
Small molecule tyrosine kinase inhibitors in glioblastoma
ARCHIVES OF PHARMACAL RESEARCH
2019.08
2019.08
Enhanced Subcellular Trafficking of Resveratrol Using Mitochondriotropic Liposomes in Cancer Cells
PHARMACEUTICS
2019.08
2019.08
Surface-functionalized exosomes for chemo-photothermal combination therapy
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
2019.07
2019.07
Dual-selective photodynamic therapy with a mitochondria-targeted photosensitizer and fiber optic cannula for malignant brain tumors
BIOMETERIALS SCIENCE
2019.07
2019.07
GRP78-Targeted HPMA Copolymer-Photosensitizer Conjugate for Hyperthermia-Induced Enhanced Uptake and Cytotoxicity in MCF-7 Breast Cancer Cells
MACROMOLECULAR BIOSCIENCE
2019.06
2019.06
Glycol chitosan-coated near-infrared photosensitizer-encapsulated gold nanocages for glioblastoma phototherapy
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
2019.01
2019.01
N,N,N-trimethyl chitosan embedded in situ Pluronic F127 hydrogel for the treatment of brain tumor
CARBOHYDRATE POLYMERS
2018.10
2018.10
pH-sensitive PEGylation of RIPL peptide-conjugated nanostructured lipid carriers: design and in vitro evaluation
INTERNATIONAL JOURNAL OF NANOMEDICINE
2018.09
2018.09
Hyaluronic acid-coated cisplatin conjugated gold nanoparticles for combined cancer treatment
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
2018.03
2018.03
Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases
INTERNATIONAL JOURNAL OF NANOMEDICINE
2017.11
2017.11
Self-Assembling Lipid-Peptide Hybrid Nanoparticles of Phospholipid-Nonaarginine Conjugates for Enhanced Delivery of Nucleic Acid
BIOMACROMOLECULES
2017.02
2017.02
Mitochondrial-targeted photosensitizer-loaded folate-albumin nanoparticle for photodynamic therapy of cancer
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
2016.12
2016.12
Self-assembled mirror DNA nanostructures for tumor-specific delivery of anticancer drugs
JOURNAL OF CONTROLLED RELEASE
2016.07
2016.07
Graphene oxide-incorporated pH-responsive folate-albumin-photosensitizer nanocomplex as image-guided dual therapeutics
JOURNAL OF CONTROLLED RELEASE
Other publication
Other publication
Patent
Patent
2023
2023
미토콘드리아 표적지향 및 글루타치온 고갈 능력을 가지는 새로운 응집유도발광 광감각제(A new aggregation-induced emission photosensitizer with mitochondrial targeting and glutathione depletion ability)
미토콘드리아 표적지향 및 글루타치온 고갈 능력을 가지는 새로운 응집유도발광 광감각제(A new aggregation-induced emission photosensitizer with mitochondrial targeting and glutathione depletion ability)
<가천대학교 산학협력단>
2021
2021
광열 나노입자, 항암제 및 히알루론산 및 PEG의 컨쥬게이트를 포함하는 광열 나노복합체(A photothermal nanocomplex comprising photothermal nanoparticle, anticancer drug and conjugate of hyaluronic acid and PEG)
<가천대학교 산학협력단>
2020
2020
광열 나노입자, 항암제 및 히알루론산 및 카텝신 B의 기질 펩타이드의 컨쥬게이트를
포함하는 광열 나노복합체(A photothermal nanocomplex comprising photothermal nanoparticle, anticancer drug and conjugate of hyaluronic acid and substrate peptide of cathepsin B)
<가천대학교 산학협력단>
2019
2019
변형 지방산 인지질 및 양이온성 폴리펩티드 컨쥬게이트를 포함하는
핵산 전달용 조성물(COMPOSITION FOR DELIVERY OF NUCLEIC ACID COMPRISING FATTY ACID MODIFIED PHOSPHOLIPID AND CATIONIC POLIPEPTIDES CONJUGATE)
<가천대학교 산학협력단>
2019
2019
약물 전달용 조성물(Composition for delivery a photosensitizer)
<가천대학교 산학협력단>
2018
2018
키토산으로 표면이 개질된 커큐민이 적재된 고체 지질 나노입자
(A liphophilic curcumin-loaded solid lipid nanoparticle surface-
modified with chitosan)
<가천대학교 산학협력단,(주) 네추럴웨이>
2018
2018
암 치료용 나노 복합체(Nanocomplex for cancer treatment)
<가천대학교 산학협력단>
2017
2017
광열 나노입자, 항암제 및 히알루론산 및
PEG의 컨쥬게이트를 포함하는 광열 나노복합체
(A photothermal nanocomplex comprising photothermal nanoparticle,
anticancer drug and conjugate of hyaluronic acid and PEG)
<가천대학교 산학협력단>
2017
2017
야관문 추출물 유래의 베타-시토스테롤-6-리노레노일-3-O-베타-D-글루코피라노사이드 (β-sitosterol-6'-linolenoyl-3-O-β-D-glucopyranoside)를 함유하는
발기부전치료제 및 이를 포함하는 성기능 개선 기능성식품 조성물
(ANTI-IMPOTENCE DRUG CONTAINING β-sitosterol-6'-linolenoyl-3-O-β-D-glucopyranoside EXTRACTED FROM LESPEDEZA CUNEATA, AND FUNCTIONAL FOODS FOR SAME)
<가천대학교 산학협력단,(주) 네추럴웨이,유상우>
2017
2017
N-트리메틸 키토산 결합 팔미트산 중합체로 표면 개질된
지용성 약물 함유 고체 지질 나노입자
(A lipophilic drug-loaded solid lipid nanoparticle surface-modified
with N-trimethyl chitosan graft palmitic acid)
<가천대학교 산학협력단>
2017
2017
고추냉이 추출물을 포함하는 대장염 예방 또는 치료용 약학적 및 식품 조성물(PHARMACEUTICAL AND FOOD COMPOSITION CONTAINING HORSERADISH EXTRACTS FOR PREVENTING OR TREATING COLITIS)
<주식회사 유니베라,가천대학교 산학협력단>
2016
2016
콜레스테롤이 공유결합된 알부민을 포함하는 나노입자 및
이에 봉입된 난용성 약물을 포함하는 난용성 약물 전달용 나노복합체
(A nanoparticle comprising albumin with cholesterol covalently bonded thereto
and nanocomplex comprising the nanoparticle and poorly water-soluble drug loaded therein)
<가천대학교 산학협력단>
2016
2016
N-트리메틸 키토산으로 표면 개질된 지용성 약물 함유 고체 지질 나노입자
<가천대학교 산학협력단>
2016
2016
알부민에 결합된 약물을 포함하는 나노입자가 봉입된
리포좀을 포함하는 약물 전달용 조성물
(Composition for drug delivery comprising Liposome
Encapsulated Nanoparticle of drug combined with Albumin)
<가천대학교 산학협력단>
2013
2013
유전자 운반체(Gene Delivery System)
<광주과학기술원>
2010
2010
ELF-ASSEMBLING MICELLE-
LIKE NANOPARTICLES FOR SYSTEMIC GENE DELIVERY
<Northeastern Univ.>
2008
2008
Encapsulation of nucleic acids in liposomes
<Ko YT, U Bicke>
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