Welcome to Lab of NanoDDS for Brain Drug Delivery

Delivering Bioactives

The best drugs can't exert their beneficial effects
if they are not reaching their target site in the body at an appropriate concentration
and for a sufficient length of time.

- Yvonne Perrie

Nanoparticulate Drug Delivery Systems (nanoDDS)

Nano-targeted agents are drug delivery systems that integrate drugs into
different nanocarriers to concentrate them in targeted issues/organs.
This strategy is also called a nanoparticulate drug delivery system (NanoDDS) and
offers high drug stability, sustained release potential,
and low drug toxicity to solve these issues. 

- Jie Li

The goals for research of nanoDDS

More specific drug targeting and delivery
Reduction in toxicity while maintaining therapeutic effects
Greater safety and biocompatibility
Faster development of new safe medicines

Blood-Brain Barrier (BBB)

The endothelial cells lining the cerebral blood vessels form the BBB,
and it is an important barrier that prevents the variation in the composition of
plasma and also protects the brain from toxins and pathogens,
which may disturb the neural function of the brain.
The BBB represents an insurmountable obstacle for a large number of drugs, including antibiotics,
antineoplastic agents, and a variety of central nervous system
(CNS)-active drugs, especially neuropeptides 

- JörgKreuter

NanoDDS for brain drug delivery

Nanotechnology-based drug delivery systems provide exciting opportunities to
overcome the BBB obstacle for the management of CNS diseases.
By altering the particle size and surface of the particle,
permeation of the drug across BBB can be improved and
also therapeutics can be delivered to the target site.
This system can be used to provide sustained release, improve the solubility of poorly soluble drugs,
protect drug against enzymatic degradation 

- K.M.Asha Spandana