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Nrf2 is a master regulator of anti-oxidative stress and anti-inflammatory responses. Surprisingly, many health beneficial/anti-cancer dietary phytochemicals found abundantly in our fruits, vegetables, nuts, among others, would activate Nrf2 resulting in induction of cellular defense detoxifying/antioxidant enzymes and inhibition of inflammatory responses in many tissues. Consequently, Nrf2 appears to be a critical factor/biomarker in cancer development and cancer prevention (Lee et al. Pharmacol Ther 2013, Su et al. Top Curr Chem 2013, Hu et al. Antioxid Redox Signal 2010)
- Cancer Prevention by Dietary Phytochemicals and NSAIDs
- Cancer Prevention by Dietary Phytochemicals via Nrf2-signaling Pathway
- Phytochemicals and Epigenetics
The impact of dietary phytochemicals/botanicals on the regulation of Nrf2-dependent pharmacogenomics: Both Nrf2 KO and WT mice were treated with dietary phytochemicals or with vehicle (control group). DNA was extracted from the organ of interest, such as the liver, prostate, or small intestine, and then hybridized to a DNA microarray. Through a comparison of the compound-treated Nrf2 KO group vs. the treated WT and non-treated Nrf2 KO groups, a large amount of Nrf2-dependant compound-induced genes was found (Barve, et al., 2008; Hu, et al., 2006a, 2006b; Nair, et al., 2006; Shen, et al., 2006; Shen, et al., 2005; Thimmulappa, et al., 2002; Wu, et al., 2011), and some of the representative groups of genes are presented.
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