Research
Lab slogan: “Contribution for science in action, not already made”
Research mission:
We study “toxicomics”, which is omics technologies applied to toxicology, in order to contribute for benefit to mankind.
Research keywords:
Toxicoproteomics, Protein-post translational modification, Drug-induced liver injury (DILI), xenobiotic metabolism, integrated omics, single cell omics
ToxicoProteomics
Toxicoproteomics is broadly defined as the global identification and characterization of proteins expressed in complex biological systems in response to a toxin, toxicant, or other adverse chemical or environmental stimulus (Wilson and Hooser, 2018). Our laboratory has set the goal of conducting toxicological studies by developing protein analysis and low molecular substance analysis techniques based on the use of mass spectrometry. The research team in the laboratory is divided into two groups, proteomics research and low molecular substance research.
Proteomics projects
[NEW] Systematic research on protein modification related to prostate cancer progression (KRF, 2021.09-2023.08)
Identification of biomarkers and development of therapeutic targets in renal cell carcinoma based on multi-omics in patients-derived tissue (KNU, 2021.05-2022.04)
Identification and mechanism study of new protein modification as a new regulator of metabolic diseases (KRF, 2021.03-2026.02)
Development of core technology for single-cell proteomics through All-In-One platform from single cell separation to analysis (KRF, 2020.06-2024.12)
Development of early diagnosis marker and diagnosis method for poisonous mushroom poisoning based on multi-omics technology (KRF, 2020.03-2023.02)
Development of mass spectrometric humic acid/microplastic compound analysis method (KRF, 2019.06-2022.02)
DMPK projects
Pharmacokinetics study in Octreotide-treated rabbit (Completed)
Pharmacokinetics study in Liraglutide-treated rat (Completed)
Identification of metabolites of natural active substances and drug interaction evaluation