Research

🧬🧪 AMCB Lab. 🔬🧫

Our research group is interested in discovering new mechanisms through the study of cell differentiation and cell signaling pathways to overcome various types of degenerative diseases.

In an increasingly aging society, effective tissue regeneration treatment is a way to shorten the healing period efficiently. In daily life, a sudden accident or disease that causes a tissue defect (such as tissue loss, inflammation, or degeneration) may delay recovery due to age or other factors. We are exploring ways to overcome these limitations from multiple perspectives. We first consider the in vivo environment, where various types of cells interact, verifying the cause and direction of overcoming at the genetic and cellular levels, and researching methods that can be combined with biomaterials to apply this knowledge to clinical practice effectively.

PROJECTS

The Intricate Roles of Immune Cells in Tissue Regeneration

Tissue regeneration is a complex process crucial for restoring damaged tissue, significantly influenced by a dynamic immune response where initial inflammation for debris clearance must transition into resolution to avoid fibrosis. While key immune cells like macrophages, neutrophils, and T/B cells are recognized for their diverse roles in this process, their precise temporal and spatial contributions and intricate signaling networks remain largely unclear. This study aims to systematically characterize these dynamic roles of various immune cell populations during regeneration, ultimately providing critical insights for enhancing regenerative medicine strategies.

Cellular Metabolism and Mitochondrial Function

Cellular metabolism and mitochondrial function are at the heart of cell differentiation, a process that involves significant metabolic reprogramming to meet the needs of specialized cells. Simultaneously, drug treatments can profoundly modulate these delicate metabolic pathways, impacting cell fate and function. This study aims to provide a comprehensive analysis of how mitochondrial function and cellular metabolism change during differentiation and how these changes are influenced by drug exposure. The findings will offer critical insights into the underlying mechanisms of cell identity and provide a foundation for advancing therapeutic strategies.

Gene-Cell Therapy for Regenerative Medicine

Tissue regeneration is often hindered in cases of significant injury or degenerative diseases, a challenge that conventional therapies struggle to address. To overcome these limitations, we are exploring gene-cell therapy, a synergistic approach that combines the therapeutic power of genetic engineering with the regenerative potential of cell therapy. By genetically modifying cells ex vivo to enhance their survival, modulate their function, or deliver therapeutic factors, and then transplanting them, we can achieve more robust and sustained tissue repair. This research aims to investigate the combined potential of this innovative strategy to promote tissue regeneration and serve as a powerful new treatment for a range of degenerative conditions.

Specific Factor Signaling Pathways of a Cell

Cell differentiation is a fundamental process precisely controlled by specific signaling pathways, where factors bind to receptors to initiate a cascade of events that ultimately dictate cell fate. Despite extensive knowledge, the exact molecular mechanisms and context-dependent nature of these pathways are not fully understood. This study aims to verify the specific signaling pathways that govern cell differentiation by systematically mapping their molecular choreography to provide a deeper understanding of how cellular identity is established and to lay the groundwork for new therapeutic strategies. Ultimately, a clearer picture of these pathways is essential for developing novel interventions to manipulate cell fate. This knowledge will be critical for advancing regenerative medicine and treating a wide range of diseases. By leveraging advanced biochemical assays, our research will provide a detailed map of these critical signaling cascades. This foundational work is therefore crucial for designing targeted therapies that can precisely control cell behavior and correct disease-related defects.

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