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Schematic of the in vivo CRISPR screen
In Vivo CRISPR-Based Genetic Screens for Target Discovery
In Vivo CRISPR-Based Genetic Screens for Target Discovery
In this project, we use CRISPR-based genetic screens in animal models to identify novel regulators of tumor responses to immunotherapy in adrenocortical carcinoma (ACC). By screening a library of epigenetic genes, we have uncovered previously unknown mechanisms that control endogenous immune responses and influence tumor sensitivity to PD-1 checkpoint blockade. These findings provide new insights into how the genetic and epigenetic landscape of ACC shapes immunotherapy outcomes and highlight potential targets for therapeutic intervention.
In this project, we use CRISPR-based genetic screens in animal models to identify novel regulators of tumor responses to immunotherapy in adrenocortical carcinoma (ACC). By screening a library of epigenetic genes, we have uncovered previously unknown mechanisms that control endogenous immune responses and influence tumor sensitivity to PD-1 checkpoint blockade. These findings provide new insights into how the genetic and epigenetic landscape of ACC shapes immunotherapy outcomes and highlight potential targets for therapeutic intervention.
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