For the complete list of publications, visit my Google Scholar profile.
Main publications (in chronological order) (*Co-first, #Co-Corresponding or &Corresponding author):
1. Chortis V*, Borges KS*, Yao C-H, ….Haigis MC, Breault DT. (2025). Glutamine antagonism suppresses tumor growth in adrenocortical carcinoma through inhibition of de novo nucleotide biosynthesis. bioRxiv.
2. Chortis V, Kariyawasam D,….Borges KS, Breault DT. (2025). FGFR2 mediates β-catenin-induced adrenocortical hyperplasia and aldosterone production. JCI insights
3. Mariniello K, Pittaway JFH, Altieri B, Borges KS,…Fassnacht M, Guasti L. (2025). Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma. Cancer Commun (Lond).
4. Borges KS*, Little III DW*, de Almeida Magalhães T*,…Salic A, Breault DT, Hammer GD. (2024). Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production. bioRxiv
5. de Almeida Magalhaes T, Liu J, Chan C, Borges KS,…Breault DT, Huang P, Salic A. (2024). Extracellular carriers control lipid-dependent secretion, delivery, and activity of WNT morphogens. Dev Cell.
6. de Almeida Magalhães T,…Filbin MG, Borges KS, Salic A, Gonzaga Tone L, Valera ET. (2023). Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in supratentorial ependymoma. Neuro Oncology.
7. Mohan DR, Borges KS,…Breault DT, Lerario AM, Hammer GD. (2023). β-Catenin-Driven Differentiation Is a Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer. Cancer Res.
8. Maria AG, Borges KS,…Tone LG, Stratakis CA. (2021). Inhibition of Aurora kinase A activity enhances the antitumor response of beta-catenin blockade in human adrenocortical cancer cells. Mol Cell Endocrinol.
9. Borges KS*, Pignatti E*,…Breault DT. (2020). Wnt/β-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice. Oncogene.
10. Pignatti E, Leng S, Yuchi Y, Borges KS,…Breault DT. (2020). Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation. Cell Rep.
11. de Almeida Magalhães T,…Tone LG, Valera ET, Borges KS#. (2020). Notch pathway in ependymoma RELA-fused subgroup: upregulation and association with cancer stem cells markers expression. Cancer Gene Ther.
12. Andrade AF, Borges KS,…Scrideli CA, Tone LG. (2017). The DNA methyltransferase inhibitor zebularine exerts antitumor effects and reveals BATF2 as a poor prognostic marker for childhood medulloblastoma. Invest New Drugs.
13. Borges KS, Arboleda VA, Vilain E. (2015). Mutations in the PCNA-binding site of CDKN1C inhibit cell proliferation by impairing the entry into S phase. Cell Div.
14. Andrade AF, Borges KS, Castro-Gamero AM,…Scrideli CA, Tone LG. (2014). Zebularine induces chemosensitization to methotrexate and efficiently decreases AhR gene methylation in childhood acute lymphoblastic leukemia cells. Anticancer Drugs.
15. Lorea CF, Moreno DA, Borges KS,…Tone LG, Scrideli CA. (2012). Expression profile of apoptosis-related genes in childhood adrenocortical tumors: low level of expression of BCL2 and TNF genes suggests a poor prognosis. Eur J Endocrinol.
Other Publications:
15. Berber M, Haykir B, Guagliardo NA, Chortis V, Borges KS, Barrett PQ, Beuschlein F, Carlone DL, Breault DT (2025). Rho-ROCK signaling and α-Catenin mediate β-Catenin-driven hyperplasia in the adrenal via adherens junctions. bioRxiv.
16. Veronez LC, Xavier AET, Nagano LF, Correa CAP; Borges KS…Tone LG, Scrideli CA. (2024). Identifying Prognostic Hub Genes and Key Pathways in Pediatric Adrenocortical Tumors through RNA Sequencing and Co-expression Analysis. Mol Cell Endocrinol.
17. Ruiz-Babot G, Eceiza A, Abollo-Jiménez F, Malyukov M, Carlone DL, Borges KS,…Bornstein SR, Breault DT. (2023). Generation of glucocorticoid-producing cells derived from human pluripotent stem cells. Cell Rep Methods.
18. Moreno DA, Junior HLR, Laranjeira ABA, Cruzeiro GAV, Borges KS,…Scrideli CA, Tone LG. (2022). Panobinostat (LBH589) increase survival in adult xenografic model of acute lymphoblastic leukemia with t(4;11) but promotes antagonistic effects in combination with MTX and 6MP. Med Oncol.
19. Veronez LC,…Borges KS, Queiroz RGP, Tone LG, Scrideli CA. (2021). MSI2 expression in adrenocortical carcinoma: Association with unfavorable prognosis and correlation with steroid and immune-related pathways. J Cell Biochem.
20. Feitosa JADS,…Tone LG, Borges KS#, Valera ET. (2020). Frequency of the TP53 p.R337H mutation in a Brazilian cohort of pediatric patients with solid tumors. Mol Biol Rep.
21. de Almeida Magalhães T*, Borges KS*&,…Tone LG. (2020). The TP53 p.R337H mutation is uncommon in a Brazilian cohort of pediatric patients diagnosed with ependymoma. Neurol Sci.
22. de Almeida Magalhães T,…Valera ET, Borges KS&. (2020). The therapeutic potential of Aurora kinases targeting in glioblastoma: from preclinical research to translational oncology. J Mol Med (Berl).
23. Silveira VS, Borges KS,…Tone LG, Scrideli CA. (2020). SHOC2 scaffold protein modulates daunorubicin-induced cell death through p53 modulation in lymphoid leukemia cells. Sci Rep.
24. Geron L, Salomão KB, Borges KS,…Scrideli CA, Tone LG. (2018). Molecular characterization of Wnt pathway and function of β-catenin overexpression in medulloblastoma cell lines. Cytotechnology.
25. Borges KS, Andrade AF,…Tone LG, Scrideli CA. (2017). The aurora kinase inhibitor AMG 900 increases apoptosis and induces chemosensitivity to anticancer drugs in the NCI-H295 adrenocortical carcinoma cell line. Anticancer Drugs.
26. Geron L*, Borges KS*&,…Scrideli CA, Tone LG. (2015). Antitumour activity of AMG 900 alone or in combination with histone deacetylase inhibitor SaHa on medulloblastoma cell lines. Neurol Res. *Co-first authors
27. Sales L, Pezuk JA, Borges KS,…de Oliveira JC. (2015). Anticancer activity of 7-epiclusianone, a benzophenone from Garcinia brasiliensis, in glioblastoma. BMC Complement Altern Med.
28. Andrade AF, Borges KS, Silveira VS. (2014). Update on the Use of l-Asparaginase in Infants and Adolescent Patients with Acute Lymphoblastic Leukemia. Clin Med Insights Oncol.
29. Silveira VS, Freire BM, Borges KS,…Tone LG, Scrideli CA. (2014). Hypoxia-related gene expression profile in childhood acute lymphoblastic leukemia: prognostic implications. Leuk Lymphoma.
30. Castro-Gamero AM, Borges KS,…Scrideli CA, Tone LG. (2013). Chromosomal heterogeneity and instability characterize pediatric medulloblastoma cell lines and affect neoplastic phenotype. Cytotechnology.
31. Castro-Gamero AM, Borges KS,…Scrideli CA, Tone LG. (2013). Tetra-O-methyl nordihydroguaiaretic acid, an inhibitor of Sp1-mediated survivin transcription, induces apoptosis and acts synergistically with chemo-radiotherapy in glioblastoma cells. Invest New Drugs.
32. Borges KS, Moreno DA, Martinelli CE Jr,…Tone LG, Scrideli CA. (2013). Spindle assembly checkpoint gene expression in childhood adrenocortical tumors (ACT): Overexpression of Aurora kinases A and B is associated with a poor prognosis. Pediatr Blood Cancer.
33. Borges KS&, Castro-Gamero AM, Moreno DA,…Scrideli CA, Tone LG. (2012). Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells. J Cancer Res Clin Oncol.
34. Castro-Gamero AM, Borges KS,…Tone LG. (2012). Inhibition of nuclear factor-κB by dehydroxymethylepoxyquinomicin induces schedule-dependent chemosensitivity to anticancer drugs and enhances chemoinduced apoptosis in osteosarcoma cells. Anticancer Drugs.
35. Gomes MV, Borges KS,…Scrideli CA, Tone LG. (2011). Abnormal methylation of histone deacetylase genes: implications on etiology and epigenetic therapy of astrocytomas. Anticancer Res.
36. Borges KS&,…Tone LG. (2011). Antiproliferative effects of Tubi-bee propolis in glioblastoma cell lines. Genet Mol Biol.