Embedded Files
Immune cell interaction in an antigen-specific manner in autoimmune bullous diseases (AIBD)
Immune cell interaction in an antigen-specific manner in autoimmune bullous diseases (AIBD)
Autoimmune bullous dermatoses (AIBDs) present as blisters and erosions in the skin and mucosa, mediated by autoantibodies that target epidermal components. Various types of AIBDs exist, such as pemphigus, bullous pemphigoid, epidermolysis bullosa acquisita, mucous membrane pemphigoid, among others. We have identified diverse immune cell activities in the context of AIBDs. An essential focus of our ongoing work is to understand the underlying mechanism of disease induction by investigating antigen-specific interaction between various immune cell subsets.Â
Autoimmune bullous dermatoses (AIBDs) present as blisters and erosions in the skin and mucosa, mediated by autoantibodies that target epidermal components. Various types of AIBDs exist, such as pemphigus, bullous pemphigoid, epidermolysis bullosa acquisita, mucous membrane pemphigoid, among others. We have identified diverse immune cell activities in the context of AIBDs. An essential focus of our ongoing work is to understand the underlying mechanism of disease induction by investigating antigen-specific interaction between various immune cell subsets.Â
Immunologic research by using 2D and 3D high-multiplex tissue imaging technique
Immunologic research by using 2D and 3D high-multiplex tissue imaging technique
The high-multiplex tissue imaging technique allows the observation of more than 40 markers on a single slide. This advanced technique enables in-depth single-cell phenotyping, particularly highlighting its advantages for analyzing numerous immune cell subsets within a spatial context, and it can be further integrated with in situ RNA hybridization methods to simultaneously detect gene expression at single-cell resolution. In our lab, we aim to identify immune-cell networks within tissues using these techniques. We believe that these findings will lead to a novel interpretation of immunologic patterns by comparing them at the single-cell level.
The high-multiplex tissue imaging technique allows the observation of more than 40 markers on a single slide. This advanced technique enables in-depth single-cell phenotyping, particularly highlighting its advantages for analyzing numerous immune cell subsets within a spatial context, and it can be further integrated with in situ RNA hybridization methods to simultaneously detect gene expression at single-cell resolution. In our lab, we aim to identify immune-cell networks within tissues using these techniques. We believe that these findings will lead to a novel interpretation of immunologic patterns by comparing them at the single-cell level.
Page updated
Google Sites
Report abuse