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Research overview
Research overview
Protein engineering is a powerful tool with tremendous potential to transform drug discovery and development.
Our research vision is to harness protein engineering to develop next-generation therapeutics that ultimately improve patient outcomes. To achieve this, our research program is organized into three interconnected areas.
1. Interrogating the antigen landscape
1. Interrogating the antigen landscape
We aim to deepen our understanding of the molecular and evolutionary constraints that shape antigen function, including the fitness costs associated with drug-resistance and immune escape mutations. These insights will identify conserved vulnerabilities that can be exploited for therapeutic intervention.
2. Engineering broad and potent therapeutics
2. Engineering broad and potent therapeutics
We will design and optimize antibodies and other protein therapeutics with enhanced breadth, potency, and durability against rapidly evolving pathogens.
3. Platforms for next-generation therapeuticÂ
3. Platforms for next-generation therapeuticÂ
We will develop and integrate cutting-edge protein engineering platforms that combine artificial intelligence (AI) and high-throughput screening to accelerate the rational design of next-generation therapeutics. Although initially focused on viral pathogens, these platform technologies will have broad applications across infectious diseases and other therapeutic areas.
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