Publications
Research Articles
Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner
Shimonty, A., Pin, F., Prideaux, M., Peng, G., Huot, J.R, Kim, H., Rosen, C.J., Spiegelman, B.M., Bonewald, L.F. “Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner” eLife, 2024, 12:RP92263.
Kim, E., Kim, H., Jedrychowski, M.P., Bakiasi, G, Park, J., Choi, Y., Kwak, S.S., Kim, D.Y., Wrann, C., Spiegelman, B.M., Tanzi, R.E., Choi, S.H., “Exercise-Induced Irisin reduces Amyloid-β deposition by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling” Neuron, 2022, PMID: 37689059.
Amelioration of Pathologic α-Synuclein-Induced Parkinson’s Disease by Irisin
Kam. T.I., Park, H., Chou, S.C., Van Vranken, J.G., Mittenbüuhler, M.J., Kim, H., A, Mu, Choi, Y.R., Karuppagounder, S.S, Biswas, D., Wang, J., Shin, Y, Loder, A., Dawson, V.L., Spiegelman, B.M., Dawson, T.M. “Amelioration of Pathologic α-Synuclein-Induced Parkinson’s Disease by Irisin” Proc. Natl. Acad. Sci. (USA), 2022, 119: e2204835119.
FAF1 Blocks Ferroptosis by Inhibiting Peroxidation of Polyunsaturated Fatty Acids
Cui, S., Simmons, G., Vale, G., Deng, Y., Kim, J., Kim, H., Zhang, R., McDonald, J., Ye, J., “FAF1 Blocks Ferroptosis by Inhibiting Peroxidation of Polyunsaturated Fatty Acids” Proc. Natl. Acad. Sci. (USA), 2022, 17: e2107189119.
Exercise hormone irisin is a critical regulator of cognitive function
Islam, M., Valaris, S., Young, M., Haley E., Luo, R., Bond, S., Kitchen R., Caldarone, B., Bettio, L., Christie, L., Schmieder, A., Soberman, R., Besnard, A., Jedrychowski, M., Kim, H., Choi, S., Tanzi, R., Spiegelman, B., Wrann, C., “Exercise hormone irisin is a critical regulator of cognitive function” Nature Metabolism, 2021, 3:1058-1070 (PMID: 34417591).
Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo
Estell, E., Le, P., Vegting, Y., Kim, H., Wrann, C., Bouxsein, M., Nagano, K., Baron, R., Spiegelman, B., Rosen, C., "Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo” eLife, 2020, 9:e58172 (PMCID: PMC7444909).
CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling
Oguri, Y.*, Shinoda, K.*, Kim, H.*, Alba, D.L., Bolus, W.R., Wang, Q., Brown, Z., Pradhan, R.N., Tajima, K., Yoneshiro, T., Ikeda, K., Chen, Y., Cheang, R.T., Tsujino, K., Kim, C.R., Greiner, V.J., Datta, R., Yang, C.D., Atabai, K., McManus, M.T., Koliwad, S.K., Spiegelman, B.M., Kajimura, S., “CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling” Cell, 2020, 182(3):563-577.e20 (PMCID: PMC7415677) (* Equal contribution as a co-first author).
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Kim, H., Wrann, C., Jedrychowski, M.,Vidoni S., Kitase Y., Nagano K., Zhou C., Chou Z., Parkman V., Novick, S., Strutzenberg T., Pascal, B., Le P., Brooks, D., Roche, A., Gerber, K., Mattheis, L., Chen, W., Tu, H., Bouxsein, M., Griffin, P., Baron, R., Rosen, C., Bonewald, L., and Spiegelman, B., “Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors” Cell, 2018, 175: 1756–1768 (PMCID: PMC6298040).
Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI
Zhang, Y., Udayakumar, D., Cai, L., Hu, Z., Kapur, P., Kho, E., Pavía-Jiménez, A., Fulkerson,M., Leon, A., Yuan, Q., Dimitrov, I., Yokoo, T., Ye, J., Mitsche, M., Kim, H., McDonald, J., Xi, Y., Aadhuranthakam, A., Dwivedi, D., Lenkinski, R., Cadeddu, J., Margulis, V., Brugarolas, J., DeBerardinis, R., and Pedrosa I., “Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI” JCI Insight, 2017, 2: e94278 (PMCID: PMC5543910).
Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin
Kim, H., Rodriguez-Navas, C., Kollipara, R., Kapur, P., Pedrosa, I., Brugarolas, J., Kittler, R., Ye, J., “Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin” Cell Reports, 2015,13:495-503 (PMCID: PMC4618234).
UAS Domain of Ubxd8 and FAF1 Polymerizes upon Interaction with Long Chain Unsaturated Fatty Acid
Kim, H., Zhang, H., Meng, D., Russell, G., Lee, J.N., Ye, J., “UAS Domain of Ubxd8 and FAF1 Polymerizes upon Interaction with Long Chain Unsaturated Fatty Acid” J. Lipid.Res., 2013, 54: 2144-2152 (PMCID: PMC3708364).
Lee, JN.*, Kim, H.*, Yao, H, Chen, Y, Weng, K, Ye, J., “Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis” Proc. Natl. Acad. Sci. (USA), 2010, 107: 21424-21429 (PMCID: PMC3003070) (* Equal contribution as a co-first author).
Yoon, H. J., Kim, H. L., Lee, S. K., Kim, H. W., Kim, H. W., Lee, J. Y., Mikami, B., and Suh, S. W. "Crystal structure of peptide deformylase from Staphylococcus aureus in complex with actinonin, a naturally occurring antibacterial agent" Proteins, 2004, 57: 639-642 (PMID: 15382235).
Kim, H.*, Yoon, H. J.*, Kim, H. W., Mikami, B., and Suh, S. W. "Crystallization and preliminary X-ray crystallographic analysis of peptide deformylase from Staphylococcus aureus" Korean J. Crystallogr., 2004, 15: 40-43 (* Equal contribution as a co-first author).
Kim, H.*, Ahn, H. J. *, Yoon, H. J., Kim, H. W., Baek, S.-H. & Suh, S. W. "Crystallization and preliminary X-ray crystallographic analysis of tRNA(m1G37) methyltransferase from Haemophilus influenzae" Acta Crystallograph Sect D Struct Biol Cryst Commun., 2003, D59: 183-184 (PMID: 12499565) (* Equal contribution as a co-first author).
Crystal structure of tRNA(m1G37) methyltransferase: Insights into tRNA recognition
Ahn, H. J., Kim, H., Yoon, H.-J., Lee, B. I., Suh, S. W., and Yang, J. K. "Crystal structure of tRNA(m1G37) methyltransferase: Insights into tRNA recognition" EMBO J., 2002, 22: 2593-2603 (PMCID: PMC156765).
Review Article
Kim, H., Ye, J. Curr. Opin. Lipidol., 2014, 25: 118-124 (PMID: 24378746).
Recent advances in label-free imaging and quantification techniques of lipid droplets in cells
Kim, H., Oh, S., Lee, S., Lee, K., Park, Y., Curr. Opin. Cell Biology., 2024, 87:102342.