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Our Research Concept
Generally, pathogenic factors for brain disorders change neuronal activity, signaling activity, and structure. The accumulated changes impair synaptic function and lead to abnormal brain connectivity and function. Therefore, the synaptic function can be the readout of brain disorders. This is the basic concept for our research.
How do we explain brain disorders?
Our research explains the correlation among changes in molecules, synapses, and behaviors. This explanation gives us a clue to understanding how we can cure and prevent brain disorders. To accomplish this research goal, we use multidisciplinary research approaches such as electrophysiology, molecular biology, biochemistry, neuropharmacology, and behavior study.
Our Research Area
Elucidation of Drug-Driven Synaptic Plasticity and Its Impact on Brain Function
A synapse is the fundamental site of communication between neurons. The strength of neurotransmission at an individual synapse varies, and neuronal circuits adjust synaptic plasticity to meet changing functional demands. Synaptic efficacy can shift bidirectionally, either increasing or decreasing in response to activity patterns. Certain pharmacological agents can induce rapid and sustained forms of synaptic plasticity, a property that has emerged as a major breakthrough in the treatment of brain disorders. Elucidating the mechanisms that drive such rapid plasticity offers a promising avenue for developing novel strategies to restore brain function.
Advanced Biotherapeutics for Brain Disorders
We focus on developing advanced biotherapeutic strategies for neurological and psychiatric disorders using multidisciplinary approaches, including gene cloning, biochemistry, electrophysiology, live-cell imaging, cell culture, and neuropharmacology. We plan to incorporate induced pluripotent stem cells (iPSCs) to establish human-relevant disease models that enable us to dissect pathogenic mechanisms and validate therapeutic targets. We investigate hormone-driven cellular metabolism and neuroimmune responses to elucidate the pathophysiology of brain disorders such as autism spectrum disorder, Alzheimer’s disease, and major depressive disorder.
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