Cell membrane-camoflaged nanoparticles: selection strategy in incurable disease treatment

Moon H, Kim J, Bae G, Choi W, Jung SH, Lee S, Lim K, Na JH, Choi JU, Kim J-H*, Lee S*

Journal of Pharmaceutical Investigation, (in press)

Fluorescence-guided tumor resection with a cathepsin B-activable, EGFR-targeted probe and a dual-mode surgical exoscope

Sung Y, Choi Y, Park SM, Choi N, Lee S, Suh SB, Kim C, Hur W, Cho S-W*, Lee D*, Ryu JH* 

European Journal of Medicinal Chemistry, 2025;300:118108 

Repurposing mesalamine for acute kidney injury through supramolecular assembly

Park B†, Park D†, Jang H, Ko YS, Lee HY, Choi YE, Choi J, Oh SW, Jo S-K, Kim SH, Kim Y, Lee S, Kim K, Kim M-G*, Yang Y*, Shim MK*

Journal of Controlled Release, 2025;385:114041. 

Development and Validation of a Highly Sensitive LC–MS/MS Method for the Precise Quantification of Sitagliptin in Human Plasma and Its Application to Pharmacokinetic Study

Song Y, Shim W-S, Song E, Park Y, Kim B-H, Lee S, Chung EK, Lee K-T* 

Molecules, 2025;30(14):2995. 

Drug repositioning of mesalamine via supramolecular nanoassembly for the treatment of drug-induced acute liver failure

Park B, Kim EH, Jang H, Kim Y, Ryu Y, Choi J, Shin D, Lee MC, Yang Y, Kim K, Lee S*, Kim SH*, Shim MK* 

Theranostics, 2025;15(3):1122-1134. 

Nitrogen-doped carbon quantum dots as a novel treatment for black fungal bone infections (Mucormycosis): in vitro and in vivo study 

Belal A*, Almalki AH*, Farghali AA*, Mahmoud R, Atta RR, Allah AE, Hassan WH, Lee S*, Kotp AA, Essam D, Hassan AHE, Ghoneim MM, Abo El-Ela, Abdelwahab,A* 

Artificial Cells, Nanomedicine and Biotechnology, 2024;52(1):131-144. 

Copper-Based Nanomedicines for Cuproptosis-Mediated Effective Cancer Treatment

Noh D, Lee H, Lee S, Sun I-C, Yoon H*

Biomaterials Research, 2024;28:1300-1320. 

Homologous Targeting Effect of Cancer Cell-Derived Liposomes (Memposomes) Mediated by Cell Adhesion Molecules: Role of E-cadherin

Cheung H†, Kang H†, Lee HJ, Chung Y, Shin H, Lee S*, Kim J-H* 

Biomolecules, 2024;14(10):1212. 

Light-Triggered PROTAC Nanoassemblies for Photodynamic IDO Proteolysis in Cancer Immunotherapy

Choi J†, Park B†, Park JY, Shin D, Lee S, Yoon HY, Kim K, Kim SH, Kim Y*, Yang Y*, Shim MK* 

Advanced Materials, 2024;36:2405475. 

Oral Delivery of Photoresponsive Milk-Derived Exosomes for the Local Therapy of Glioblastoma

Choi J, Jang H, Park D, Park B, Jang Y, Lee S, Kim SH, Shim MK*, Yang Y* 

ACS Materials Letters, 2024;6:4019-4027. 

Cell membrane camouflaged nanoparticle strategy and its application in brain disease: a review

Kim B†, Park B†, You S, Jung SH, Lee S, Lim K, Choi YJ, Kim J-H*, Lee S* 

Journal of Pharmaceutical Investigation, 2024;54(4):435-451. 

Development and optimization of vildagliptin solid lipid nanoparticles loaded ocuserts for controlled ocular delivery: A promising approach towards treating diabetic retinopathy

Ramadan AEH, Elsayed MMA*, Elsayed A, Fouad MA, Mohamed MS, Lee S*, Mahmoud RA, Sabry SA, Ghoneim MM, Hassan AHE, Abd Elkarim RA, Belal A, El-Shenawy AA 

International Journal of Pharmaceutics: X, 2024;7:100232. 

Mucoadhesive Mesalamine Prodrug Nanoassemblies to Target Intestinal Macrophages for the Treatment of Inflammatory Bowel Disease

Park B†, Han G†, Jin DY, Gil KC, Shin D, Lee J, Park JY, Jang H, Park D, Lee S, Kim K, Yang Y, Kim Y, Kim J-S, Kim SH*, Shim MK*  

ACS Nano, 2024;18(25):16297-16311. 

In vivo toxicity evaluation of tumor targeted glycol chitosan nanoparticles in healthy mice: repeated high-dose of glycol chitosan nanoparticles potentially induce cardiotoxicity 

Chang H†, Yhee JY†, Jeon S, Shim MK, Yoon HY, Lee S*, Kim K* 

Journal of Nanobiotechnology, 2023;21(1):82.

Liposomes targeting the cancer cell-exposed receptor, claudin-4, for pancreatic cancer chemotherapy

Bang C, Park MG, Cho IK, Lee D-E, Kim GL, Jang EH, Shim MK, Yoon HY, Lee S*, Kim J-H* 

Biomaterials Research, 2023;27(53):1-12. 

Advances in mRNA therapeutics for cancer immunotherapy: From modification to delivery

Han G, Noh D, Lee H, Lee S, Kim S, Yoon HY*, Lee SH*

Advanced Drug Delivery Reviews, 2023;199:114973. 

Exploring the Antimicrobial Activity of Sodium Titanate Nanotube Biomaterials in Combating Bone Infections: An In Vitro and In Vivo Study

Almalki AH, Hassan WH, Farghali A, Saleh RM, Allah AE, Abdelwahab A, Hassan AHE, Ghoneim MM, Abdullah O, Mahmoud R, El-Ela FIA, Belal A*, Lee S* 

Antibiotics, 2023;12(5):799. 

Dual Effect of Chemo-PDT with Tumor Targeting Nanoparticles Containing iRGD Peptide

Kim GL, Park B, Jang EH, Gu J, Seo SR, Cheung H, Lee HJ, Lee S*, Kim J-H* 

Pharmaceutics, 2023;15(2):614. 

Recent Trend of Ultrasound-Mediated Nanoparticle Delivery for Brain Imaging and Treatment 

Jo SH, Sun I-C, Ahn C-H, Lee S*, Kim K* 

ACS Applied Materials & Interfaces, 2023;15(1):120-137.

Protective effect of 7-hydroxyl-1-methylindole-3-acetonitrile on the intestinal mucosal damage response to inflammation in mice with DSS-induced colitis 

Chung K-S, Park S-E, Lee J-H, Kim S-Y, Han H-S, Lee YS, Jung S-H, Jang E, Lee S, Lee K-T* 

Chemico-Biological Interactions, 2023;370:110316. 

3ʹ,4ʹ-Dihydroxyflavone mitigates inflammatory responses by inhibiting LPS and TLR4/MD2 interaction

Lee H-H, Shin J-S, Chung K-S, Kim J-M, Jung S-H, Yoo H-S, Hassan A, Lee JK, Inn K-S, Lee S, Kim N-J*, Lee K-T* 

Phytomedicine, 2023;109:154553. 

Ligand-controlled regiodivergent direct arylation of indoles via oxidative boron Heck reaction

Yang Y-S†, Lee S†, Son SH, Yoo H-S, Jang YH, Shin J-W, Won H-J, Sim J*, Kim N-J* 

Organic Chemistry Frontiers, 2022;9:5906-5911. 

Anti-Colitic Effect of an Exopolysaccharide Fraction from Pediococcus pentosaceus KFT-18 on Dextran Sulfate Sodium-Induced Colitis through Suppression of Inflammatory Mediators

Lee J-H, Chung K-S, Shin J-S, Jung S-H, Lee S, Lee M-K, Hong H-D, Rhee YK*, Lee K-T* 

Polymers, 2022;14(17):3594. 

Potentially Inappropriate Medication Use in Patients with Dementia

Yoon K†, Kim J-T†, Kwack W-G, Kim D, Lee K-T, Yang S, Lee S*, Choi Y-J*, Chung E-K* 

International Journal of Environmental Research and Public Health, 2022;19(18):11426. 

Hesperidin Improves Memory Function by Enhancing Neurogenesis in a Mouse Model of Alzheimer’s Disease 

Lee D†, Kim N†, Jeon SH, Gee MS, Ju Y-J, Jung M-J, Cho JS, Lee Y, Lee S*, Lee JK* 

Nutrients, 2022;14(15):3125. 

Changes in subcellular localization of Lysyl-tRNA synthetase and the 67-kDa laminin receptor in epithelial ovarian cancer metastases

Lee DH†, Paik ES†, Cho Y-J†, Lee Y-Y, Lee B, Lee EJ, Choi J-J, Choi C-H, Lee S, Choi JW*, Lee J-W* 

Cancer Biomarkers, 2022;35:99-109. 

Targeting of claudin-4 by Clostridium perfringens enterotoxin-conjugated polysialic acid nanoparticles for pancreatic cancer therapy

Shim MK†, Na JH†, Cho IK, Jang EH, Park J, Kim J-H*, Lee S*

Journal of Controlled Release, 2021;331:434-442. 

Cannabinoid Receptor Type 1 Regulates Drug Reward Behavior via Glutamate Decarboxylase 67 Transcription

Gu SM, Seo S, Park D, Kim S, Lamichhane S, Han K-M, Kim Y-H, Lee S, Hong JT, Cha HJ*, Yun J* 

International Journal of Molecular Sciences, 2021;22(19):10486. 

Availability of indirect atmospheric plasma from a dielectric barrier discharge device on biofilm-forming bacteria

Na JH†, Lee JG†, Hong SC, Seo JM, Lee JP, Lee Y, Kim JH, Na YS*, Park JU*, Lee S* 

Current Applied Physics, 2020;20(12):1307-1313. 

Amentoflavone, active compound of Selaginella tamariscina, inhibits in vitro and in vivo TGF-β-induced metastasis of human cancer cells

Kim GL, Jang EH, Lee D-E, Bang C, Kang H, Kim SH, Yoon SY, Lee DH, Na JH, Lee S, Kim J-H* 

Archives of Biochemistry and Biophysics, 2020;687:108384. 

Dual-Modal Imaging-Guided Precise Tracking of Bioorthogonally Labeled Mesenchymal Stem Cells in Mouse Brain Stroke

Lim S†, Yoon HY†, Jang HJ, Song S, Kim W, Park J, Lee KE, Jeon S, Lee S, Lim D-K, Kim B-S, Kim D-E*, Kim K* 

ACS Nano, 2019;13(10):10991-11007. 

Visible light-induced apoptosis activatable nanoparticles of photosensitizer-DEVD-anticancer drug conjugate for targeted cancer therapy

Um W†, Park J†, Ko H, Lim S, Yoon HY, Shim MK, Lee S, Ko YJ, Kim MJ, Park JH, Lim D-K, Byun Y, Kwon IC, Kim K* 

Biomaterials, 2019;224:119494. 

Carrier-free nanoparticles of cathepsin B-cleavable peptide-conjugated doxorubicin prodrug for cancer targeting therapy

Shim MK†, Park J†, Yoon HY, Lee S, Um W, Kim JH, Kang SW, Seo JW, Hyun SW, Park JH, Byun Y, Kwon IC, Kim K* 

Journal of Controlled Release, 2019;294:376-389. 

Caspase-3/-7-Specific Metabolic Precursor for Bioorthogonal Tracking of Tumor Apoptosis

Shim MK†, Yoon HY†, Lee S, Jo MK, Park J, Kim J-H, Jeong SY, Kwon IC, Kim K* 

Scientific Reports, 2017;7(1):16635. 

Nano-sized metabolic precursors for heterogeneous tumor-targeting strategy using bioorthogonal click chemistry in vivo

Lee S†, Jung S†, Koo H, Na JH, Yoon HY, Shim MK, Park J, Kim J-H, Lee S, Pomper MG, Kwon IC, Ahn C-H*, Kim K* 

Biomaterials, 2017;148:1-15. 

Extracellular matrix remodeling in vivo for enhancing tumor-targeting efficiency of nanoparticle drug carriers using the pulsed high intensity focused ultrasound

Lee S†, Han H†, Koo H, Na JH, Yoon HY, Lee KE, Lee H, Kim H, Kwon IC, Kim K* 

Journal of Controlled Release, 2017;263:68-78. 

In vivo stem cell tracking with imageable nanoparticles that bind bioorthogonal chemical receptors on the stem cell surface

Lee S†, Yoon HI†, Na JH, Jeon S, Koo H, Park JH, Cho YW, Kim SK, Lee T, Kim D, Lee S, Pomper MG, Kwon IC, Kim K* 

Biomaterials, 2017;139:12-29. 

Physiological Effects of Ac4ManNAz and Optimization of Metabolic Labeling for Cell Tracking

Lee S-S†, Lee D-E†, Shim H-E, Lee S, Jung T, Oh J-H, Lee H-A, Moon S-H, Jeon J, Yoon S, Kim K, Kang S-W* 

Theranostics, 2017;7(5):1164-1176. 

Artificial Chemical Reporter Targeting Strategy Using Bioorthogonal Click Reaction for Improving Active-Targeting Efficiency of Tumor

Yoon HY, Shin ML, Shim MK, Lee S, Na JH, Koo H, Lee H, Kim J-H, Lee KY, Kim K, Kwon IC* 

Molecular Pharmaceutics, 2017;14(5):1558-1570. 

Cathepsin B-Specific Metabolic Precursor for In Vivo Tumor-Specific Fluorescence Imaging 

Shim MK†, Yoon HY†, Ryu JH, Koo H, Lee S, Park JH, Kim J-H, S. Lee, Pomper MG, Kwon IC, Kim K* 

Angewandte Chemie International Edition, 2016;55(47):14698-14703. 

Non-invasive stem cell tracking in hindlimb ischemia animal model using bioorthogonal copper-free click chemistry

Lee S†, Lee SY†, Lee J, Yhee JY, Yoon HI, Park S-J, Koo H, Moon S-H, Lee H, Cho YW, Kang S-W, Lee S-Y, Kim K* 

Biochemical and Biophysical Research Communications, 2016;479(4):779-786. 

Precise Targeting of Liver Tumor Using Glycol Chitosan Nanoparticles: Mechanisms, Key Factors, and Their Implications

Na JH†, Koo H†, Lee S, Han SJ, Lee KE, Kim S, Lee H, Lee S, Choi K, Kwon IC, Kim K* 

Molecular Pharmaceutics, 2016;13(11):3700-3711. 

Chemical gas-generating nanoparticles for tumor-targeted ultrasound imaging and ultrasound-triggered drug delivery

Min HS†, Son S†, You DG, Lee TW, Lee JW, Lee S, Yhee JY, Lee J, Han MH, Park JH, Kim SH, Choi K, Park K, Kim K, Kwon IC* 

Biomaterials, 2016;108:57-70. 

T1-Weighted MR imaging of liver tumor by gadolinium-encapsulated glycol chitosan nanoparticles without non-specific toxicity in normal tissues 

Lee S†, Na JH†, Koo H, Han H, Lee KE, Han SJ, Choi SH, Kim H, Lee S, Kwon IC, Choi KW, Kim K* 

Nanoscale, 2016;8(18):9736-9745. 

Bioorthogonal Copper Free Click Chemistry for Labeling and Tracking of Chondrocytes In Vivo 

Yoon HI†, Yhee JY†, Na JH, Lee S, Lee H, Kang S-W, Chang H, Ryu JH, Lee S, Kwon IC, Cho YW, Kim K* 

Bioconjugate Chemistry, 2016;27(4):927-936.

Advances in targeting strategies for nanoparticles in cancer imaging and therapy  

Yoon HI†, Yhee JY†, Na JH, Lee S, Lee H, Kang S-W, Chang H, Ryu JH, Lee S, Kwon IC, Cho YW, Kim K* 

Nanoscale, 2014;6(22):13383-13390. 

Theranostic nanoparticles for future personalized medicine

Ryu JH, Lee S, Son S, Kim SH, Leary JF, Choi K, Kwon IC*

Journal of Controlled Release, 2014;190:477-484. 

Tailoring Polymersome Bilayer Permeability Improves Enhanced Permeability and Retention Effect for Bioimaging

Lai MH, Lee S, Smith CE, Kim K, Kong H* 

ACS Applied Materials & Interfaces, 2014;6(13):10821-10829. 

DNA Amplification in Neutral Liposomes for Safe and Efficient Gene Delivery

Lee S, Koo H, Na JH, Lee KY, Jeong SY, Choi K, Kim SH, Kwon IC*, Kim K* 

ACS Nano, 2014;8(5):4257-4267. 

Tumor-Homing Glycol Chitosan-Based Optical/PET Dual Imaging Nanoprobe for Cancer Diagnosis

Lee S†, Kang S-W†, Ryu JH, Na JH, Lee DE, Han SJ, Kang CM, Choe YS, Lee KC, Leary JF, Choi K, Lee KH, Kim K* 

Bioconjugate Chemistry, 2014;25(3):601-610. 

Chemical Tumor-Targeting of Nanoparticles Based on Metabolic Glycoengineering and Click Chemistry

Lee S†, Koo H†, Na JH, Han SJ, Min HS, Lee SJ, Kim SH, Yun SH, Choi K, Jeong SY, Kwon IC, Kim K* 

ACS Nano, 2014;8(3):2048-2063. 

Cell Labeling and Tracking Method without Distorted Signals by Phagocytosis of Macrophages 

Lee S†, Kang S-W†, Na JH, Yoon HI, Lee DE, Koo H, Cho YW, Kim SH, Jeong SY, Kwon IC, Choi K, Kim K* 

Theranostics, 2014;4(4):420-431. 

Tumor-Targeting Transferrin Nanoparticles for Systemic Polymerized siRNA Delivery in Tumor-Bearing Mice

Yhee JY†, Lee SJ†, Lee S, Song S, Min HS, Kang S-W, Jeong SY, Kwon IC, Kim SH, Kim K* 

Bioconjugate Chemistry, 2013;24(11):1850-1860. 

In vivo fluorescence imaging for cancer diagnosis using receptor-targeted epidermal growth factor-based nanoprobe

Ryu JH†, Shin M†, Kim SA, Lee S, Kim H, Koo H, Kim B-S, Song HK, Kim SH, Choi K, Kwon IC, Jeon H, Kim K* 

Biomaterials, 2013;34(36):9149-9159. 

Facile Method To Radiolabel Glycol Chitosan Nanoparticles with 64Cu via Copper-Free Click Chemistry for MicroPET Imaging

Lee D-E†, Na JH†, Lee S, Kang CM, Kim HN, Han SJ, Choe YS, Jung K-H, Choi K, Kwon IC, Jeong SY, Lee K-H*, Kim K* 

Molecular Pharmaceutics, 2013;10(6):2190-2198. 

Cancer targeting strategies in nanomedicine: Design and application of chitosan nanoparticles

Jee J-P†, Na JH†, Lee S, Kim SH, Choi K, Yeo Y, Kwon IC*

Current Opinion in Solid State & Materials Science, 2012;16(6):333-342. 

Bioorthogonal Copper-Free Click Chemistry In Vivo for Tumor-Targeted Delivery of Nanoparticles 

Lee S†, Koo H†, Na JH, Kim SH, Hahn SK, Choi K, Kwon IC, Jeong SY, Kim K* 

Angewandte Chemie International Edition, 2012;51(47):11836-11840. 

Blood-pool multifunctional nanoparticles formed by temperature-induced phase transition for cancer-targeting therapy and molecular imaging

Lee S†, Oh KS†, Na JH, Kim JY, Kim DE, Kim K, Kwon IC, Yuk SH*, Jeong SY*

International Journal of Pharmaceutics, 2012;437:192-202. 

Effect of the stability and deformability of self-assembled glycol chitosan nanoparticles on tumor-targeting efficiency

Na JH†, Lee SY†, Koo H, Lee S, Min KH, Jeong SY, Yuk SH, Kim K, Kwon IC* 

Journal of Controlled Release, 2012;163(1):2-9. 

In vivo NIRF Imaging of Tumor Targetability of Nanosized Liposomes in Tumor-Bearing Mice 

Lee S, Lee SY, Park S, Ryu JH, Na JH, Koo H, Lee KE, Jeon H, Kwon IC, Kim K*, Jeong SY* 

Macromolecular Bioscience, 2012;12(6):849-56. 

Real-time and non-invasive optical imaging of tumor-targeting glycol chitosan nanoparticles in various tumor models

Na JH, Koo H, Lee S, Park K, Yoo H, Park JH, Jeong SY, Kim K, Kwon IC*

Biomaterials, 2011;32(22):5252-5261.