Publications

Selected Publications

  • Doucette, W. T., Smedley, E. B., Ruiz-Jaquez, M., Khokhar, J. Y., Smith, K. S., Chronic chemogenetic manipulation of ventral pallidum targeted neurons in male rats fed an obesogenic diet. Brain Res. 2022 June 1. https://doi.org/10.1016/j.brainres.2022.147886

  • Quansah Amissah, R., Vogt, N. A., Chen, C., Urban, K., Khokhar, J. Y., Prevalence and characteristics of cannabis-induced toxicoses in pets: Results from a survey of veterinarians in North America. PLoS One. 2022 April 20. https://doi.org/10.1371/journal.pone.0261909

  • Rizk, A. A., Jenkins, B. W., Al-Sabagh, Y., Hamidullah, S., Reitz, C. J., Rasouli, M., Martino, T. A., Khokhar, J. Y., The Impact of Sex, Circadian Disruption, and the Clock Δ19/Δ19 Genotype on Alcohol Drinking in Mice. Genes (Basel). 2022 April 15. https://doi.org/10.3390/genes13040701

  • Kayir, H., Jenkins, B. W., Alural, B., Khokhar, J. Y., Clozapine Increases Nestin Concentration in the Adult Male Rat Hippocampus: A Preliminary Study. Int J Mol Sci. 2022 March 22. https://doi.org/10.3390/ijms23073436

  • Ruffolo, J., Frie, J. A., Thorpe, H. H. H., Talhat, M. A., Khokhar, J. Y., Alcohol and Vaporized Nicotine Co-Exposure During Adolescence Contribute Differentially to Sex-Specific Behavioral Effects in Adulthood. Nicotine Tob. Res. 2021 December 3. https://doi.org/10.1093/ntr/ntab250

  • Jenkins, B. W., Buckhalter, S., Perreault, M. L., Khokhar, J. Y., Cannabis Vapour Exposure Alters Neural Circuit Oscillatory Activity in A Neurodevelopmental Model of Schizophrenia: Exploring the Differential Impact of Cannabis Constituents. Schizophr. Bull. 2021 November 20. https://doi.org/10.1093/schizbullopen/sgab052

  • Sullivan, E. D.K., Locke, L. N., Wallin, D. J., Khokhar, J. Y., Bragg, E. M., Henricks, A. M., Doucette, W. T., The Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat. Front Behav Neurosci. 2021 November 11. https://doi.org/10.3389/fnbeh.2021.760791

  • Frie, J. A., Nolan, C. J., Murray, J. E., Khokhar, J. Y., Addiction-Related Outcomes of Nicotine and Alcohol Co-use: New Insights Following the Rise in Vaping. Nicotine Tob Res. 2021 Nov 10. https://doi.org/10.1093/ntr/ntab231

  • Ellner, D., Hallam, B., Frie, J. A., Thorpe, H. H. A., Shoaib, M., Kayir, H., Jenkins, B. W., Khokhar, J. Y., Discordant Effects of Cannabinoid 2 Receptor Antagonism/Inverse Agonism during Adolescence on Pavlovian and Instrumental Reward Learning in Adult Male Rats. Front Synaptic Neurosci. https://doi.org/10.3389/fnsyn.2021.732402

  • Wallin, D. J., Sullivan, E. D. K., Bragg, E. M., Khokhar, J. Y., Lu, H., Doucette, W. T., Acquisition of resting-state functional magnetic resonance imaging data in the rat. J Vis Exp. https://dx.doi.org/10.3791/62596

  • Buckhalter, S., Soubeyrand, E., Ferrone, S. A. E., Rasmussen, D. J., Manduca, J. D., Al-Abdul Wahid, S., Frie, J. A., Khokhar, J. Y., Akhtar, T. A., Perreault, M. L., The antidepressant-like and analgesic effects of kratom alkaloids are accompanied by changes in low frequency oscillations but not ΔFosB accumulation. Front Pharmacol; 12: 696461. https://doi.org/10.3389/fphar.2021.696461

  • McKie, G. L., Shamshoum, H., Hunt, K. L., Thorpe, H. H. A., Dibe, H. A., Khokhar, J. Y., Doucette, C. A., Wright, D. C., Intermittent Cold Exposure Improves Glucose Homeostasis Despite Exacerbating Diet-Induced Obesity in Mice Housed at Thermoneutrality. J Physiol. 2021 Jun 30. https://doi.org/10.1113/JP281774

  • Theriault, R. K., St-Denis, M., Hewitt, T., Khokhar, J. Y., Lalonde, J., Perreault, M. L., Sex-specific cannabidiol- and iloperidone-induced neuronal activity changes in an in vitro MAM model system of schizophrenia. Int J Mol Sciences. 2021 May 24;22(11):5511. https://doi.org/10.3390/ijms22115511

  • Oleson E. B., KhokharJ. Y. Cannabinoids: Emerging developments in neuropsychopharmacology and biological psychiatry. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 15:110305. https://doi.org/10.1016/j.pnpbp.2021.110305

  • Renda, B., Andrade, A., Stone, A. P., El Azali, R., Sharivker, M., Khokhar, J. Y., Antenos, M., Murray, J. E., Adolescent nicotine and footshock exposure augments adult nicotine self-administration and drug-seeking without affecting baseline anxiety-like behaviour or stress responsivity in male rats. Psychopharmacology 2021 Mar 1. https://doi.org/10.1007/s00213-021-05803-0

  • Misner, M., Taborek, A., Dufour, J., Sharifi, L., Khokhar, J. Y., Favetta, L. A., 2021, Effects of delta-9 tetrahydrocannabinol (THC) on oocyte competence and early embryonic development. Front. Toxicol. 23 March 2021 https://doi.org/10.3389/ftox.2021.647918

  • Jenkins, B. W., Khokhar, J. Y. 2021. Cannabis use and mental illness: understanding circuit dysfunction through preclinical models. Front. Psychiatry. https://doi.org/10.3389/fpsyt.2021.597725

  • Thorpe, H. A., Talhat, A., Khokhar, J. Y. 2020. High genes: Genetic underpinnings of cannabis use phenotypes. Progress in Neuro-Psychopharmacology and Biological Psychiatry. https://doi.org/10.1016/j.pnpbp.2020.110164

  • Catharine A. Mielnik, Kim S. Sugamori, David B. Finlay, Hayley H. A. Thorpe, Matthieu Schapira, Nirunthan Sivananthan, Chun Kit Li, Vincent M. Lam, Sean Harrington, Mostafa H. Abdelrahman, Laurent A. Trembleau, W. McIntyre Burnham, Jibran Y. Khokhar, Ali Salahpour, Amy J. Ramsey, Michelle Glass, Iain R. Greig, Ruth A. Ross. 2020. A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models. Neuropsychopharmacology. https://doi-org.subzero.lib.uoguelph.ca/10.1038/s41386-020-00876-5

  • Hamidullah, S., Lutelmowski, C. D., Creighton, S. D., Luciani, K. R., Frie, J. A., Winters, B. D., Khokhar, J. 2020. Effects of vapourized THC and voluntary alcohol drinking during adolescence on cognition, reward, and anxiety-like behaviours in rats. Neuro-Psychopharmacology and Biological Psychiatry. https://doi.org/10.1016/j.pnpbp.2020.110141

  • Frie, J. A., Underhill, J., Zhao, B., Guglielmo, G., Tyndale, R. F., Khokhar, J. Y. 2020. OpenVape: an Open-Source E-Cigarette Vapour Exposure Device for Rodents. eNeuro. https://doi.org/10.1523/ENEURO.0279-20.2020

  • Renda, B., Andrade, A. K., Frie, J. A., Sgarbrossa, C. L., Murray, J. E., Khokhar, J. Y. 2020. High-dose adolescent nicotine exposure permits spontaneous nicotine self-administration in adult male rats. Drug and Alcohol Dependence. https://doi.org/10.1016/j.drugalcdep.2020.108215

  • Hamidullah, S., Thorpe, H. A., Frie, J. A., Mccurdy, R. D., Khokhar, J. Y. 2020. Adolescent Substance Use and the Brain: Behavioral, Cognitive and Neuroimaging Correlates. Front. Hum. Neurosci. https://doi.org/10.3389/fnhum.2020.00298

  • Luciani, K. R., Frie, J. A., Khokhar, J. Y. 2020. An Open Source Automated Bar Test for Measuring Catalepsy in Rats. eNeuro. https://doi.org/10.1523/ENEURO.0488-19.2020

  • Thorpe, H. A., Hamidullah, S., Jenkins, B. W., Khokhar, J. Y. 2019. Adolescent Neurodevelopment and Substance Use: Receptor Expression and Behavioral Consequences. Pharmacology & Therapeutics. https://doi.org/10.1016/j.pharmthera.2019.107431

  • Nelong, T. F., Jenkins, B. W., Perreault, M. L., Khokhar, J. Y. 2019. Extended Attenuation of Corticostriatal Power and Coherence after Acute Exposure to Vapourized Δ9- Tetrahydrocannabinol in Rats. Canadian Journal of Addiction. 10(3): 60-66. doi: 10.1097/CXA.0000000000000063

  • Dwiel, L. L., Khokhar, J. Y., Connerney, M. A., Green, A. I., Doucette, W. T. 2019. Finding the balance between model complexity and performance: Using ventral striatal oscillations to classify feeding behavior in rats. PLOS Computational Biology. 15(4). https://doi.org/10.1371/journal.pcbi.1006838

  • Frie, J. A. and Khokhar, J. Y. 2019. An open source automated two-bottle choice test apparatus for rats. HardwareX. https://doi.org/10.1016/j.ohx.2019.e00061

  • Green A. I. and Khokhar, J. Y. 2017. Addiction and Schizophrenia: A Translational Perspective. Schizophrenia Res. http://doi.org/10.1016/j.schres.2017.10.008

  • Whitfield-Gabrieli, S., Fischer, A. S., Henricks, A. M., Khokhar, J. Y., Roth, R. M., Brunette, M. F., Green, A. I. 2017. Understanding marijuana’s effects on functional connectivity of the default mode network in patients with schizophrenia and co-occurring cannabis use disorder: A Pilot Investigation. Schizophrenia Res. http://doi.org/10.1016/j.schres.2017.07.029

  • Khokhar, J. Y., Dwiel, L., Henricks, A., Doucette, W. T., Green, A. I. 2017. The Link Between Schizophrenia and Substance Use Disorder: A Unifying Hypothesis. Schizophrenia Res. http://doi.org/10.1016/j.schres.2017.04.016

  • Khokhar, J. Y. and Todd, T. P. 2017. Behavioral Predictors of Alcohol Drinking in a Neurodevelopmental Rat Model of Schizophrenia and Co-occurring Alcohol Use Disorder. Schizophrenia Res. http://dx.doi.org/10.1016/j.schres.2017.02.029

  • Khokhar, J. Y., Green, A. I. 2016. Effects of iloperidone, combined with desipramine, on alcohol drinking in the Syrian golden hamster. Neuropharmacology. Jun;105:25-34.

  • Doucette, W., Khokhar, J. Y., Green, A. I. 2015. Nucleus Accumbens deep brain stimulation in a rat model of binge eating. Transl. Psychiatry. 5, e695; doi:10.1038/tp.2015.197.

  • Chau, D. T., Khokhar, J. Y., Gulick, D., Dawson, R., Green, A. I. 2015. Desipramine enhances the ability of paliperidone to reduce alcohol drinking. J. Psych. Res. Oct; 69: 9–18.

  • Khokhar, J. Y., Chau, D. T., Dawson, R., Green, A. I. 2015. Clozapine reconstructed: Haloperidol’s ability to reduce alcohol Intake In the Syrian golden hamster can be enhanced through noradrenergic modulation by desipramine and idazoxan. Drug Alcohol Depen. July; 152:277–281.

  • Gulick, D., Chau, D. T., Khokhar, J. Y., Dawson, R., Green, A. I. 2014. Desipramine enhances the ability of risperidone to decrease alcohol intake in the Syrian golden hamster. Psych. Res. Aug 30;218(3):329-34.

  • Khokhar, J. Y. and Tyndale, R. F. 2014. Intracerebroventricularly and Systemically Delivered Inhibitor of Brain Cyp2b (C8-Xanthate), Even Following Chlorpyrifos Exposure, Reduces Chlorpyrifos Activation and Toxicity in Male Rats. Toxicol. Sci. Jul;140(1):49-60.

  • Chau, D.T., Khokhar, J. Y., Dawson, R., Ahmed, J., Xie, H., Green, A. I., 2013. The comparative effects of clozapine versus haloperidol on initiation and maintenance of alcohol drinking in male alcohol-preferring P rat. Alcohol. Dec;47(8):611-8.

  • Zhou, K., Khokhar, J. Y., Bin, Z., and Tyndale, R. F. 2013. First demonstration that CYP2D-mediated opiate metabolic activation alters analgesia in vivo. Biochem Pharmacol.15;85(12): 1848-55.

  • Khokhar, J. Y. and Tyndale, R. F. 2012. Rat Brain Cyp2b-Enzymatic Activation Of Chlorpyrifos To The Oxon Mediates Cholinergic Neurotoxicity. Toxicol. Sci. 126(2):325-35.

  • Khokhar, J.Y. and Tyndale, R.F 2011. Drug metabolism within the brain changes drug response: Selective manipulation of brain CYP2B alters propofol effects. Neuropsychopharmacology. 36(3):692-700.

  • Khokhar, J. Y., Miksys, S., Tyndale, R. F. 2010. Rat brain CYP2B induction by nicotine is persistent and does not involve nicotinic acetylcholine receptors. Brain Res. 1348:1-9.

  • Khokhar, J. Y., Ferguson, C., Zhu, A., Tyndale, R. F. 2010. Pharmacogenetics of drug dependence: Role of gene variations in susceptibility and treatment. Annu. Rev. Pharmacol. Toxicol. 50:39-61.

  • Yue J., Khokhar J. Y., Miksys S., Tyndale R. F. 2009. Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake. Eur. J. Pharmacol. 609: 88-95/