Ketamine

Ketamine is a dissociative analgesic indicated for the treatment of severe agitation, musculoskeletal pain, pain management for pacing and cardioversion, ventilatory difficulty secondary to bucking or combativeness in intubated patients, and for CPR-induced awareness. Ketamine's safety profile makes it an excellent option for extremity and back pain. It is classified by the DEA as a Schedule III agent and is tracked using our standard Controlled Dangerous Substance procedures.

The dosing is very different for each of the indications and routes of administration. To avoid dosing errors, ALS clinicians must be aware of and confirm the proper concentration prior to administration. This is a by-the-book medication.

ALS clinicians must view this site and pass the quiz at the bottom of the presentation prior to using ketamine.

Low concentration 

Low concentration ketamine is given IV/IO for severe agitation, pain management, tube bucking in intubated patients and CPR-induced awareness. It comes in a concentration of 10mg/mL. We carry vials of 200mg in 20mL which are physically larger than the high concentration vials and will not include heat shrink labeling.

High concentration 

High concentration ketamine is given IM for severe agitation (and IM/IN for pain management when supply chain is available). It comes in a concentration of 100mg/mL. We carry vials of 500mg in 5mL that will include "High Alert CONCENTRATED" heat shrink labeling around the cap and top. 

High concentration ketamine is 10 times stronger than the low concentration - be careful! 

High concentration (left)

Low concentration (right)

Clinical Pearl

While it is feasible to dilute the high concentration ketamine, the risk of error is high!

Clinicians must not dilute ketamine.

Documenting the administration of ketamine must include the following:

- Record administration of ketamine in eMeds using the medication field

- Record administration of ketamine in the CDS tracker

- If ketamine is administered to treat severe agitation, the eMeds narrative must include, "the patient was a danger to self [and/or] others". 

Note - The Quality Assurance office will review all calls where ketamine was administered.