Lectins are a broad class of proteins that bind to carbohydrates or their constituent monosaccharides. By recognizing glycans present on the surfaces of proteins and cells, lectins play essential roles in numerous biological processes, including immune responses and cell adhesion.
Using structural biology techniques such as X-ray crystallography, along with interaction analyses including isothermal titration calorimetry (ITC), we investigate lectin function at the molecular level. In addition, through protein engineering and computational design, we aim to redesign lectins and develop high-performance artificial lectins with tailored specificities and enhanced functionality.
Based on protein structural information, I use computational approaches to design proteins with custom-designed structures and functions. My research focuses on creating novel proteins with desired properties by integrating structural insights with advanced protein engineering and computational design methodologies.