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List of Publications:
List of Publications:
Won, T.H., Bok, J.W., Nadig, N. et al. Copper starvation induces antimicrobial isocyanide integrated into two distinct biosynthetic pathways in fungi. Nat Commun 13, 4828 (2022). https://doi.org/10.1038/s41467-022-32394-x
Khokhani D, Carrera Carriel C, Vayla S, Irving TB, Stonoha-Arther C, Keller NP, Ané JM. Deciphering the Chitin Code in Plant Symbiosis, Defense, and Microbial Networks. Annu Rev Microbiol. 2021 Oct 8;75:583-607. doi: 10.1146/annurev-micro-051921-114809. PMID: 34623896.
Raffa N, Won TH, Sukowaty A, Candor K, Cui C, Halder S, Dai M, Landero-Figueroa JA, Schroeder FC, Keller NP. Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2015224118. doi: 10.1073/pnas.2015224118. PMID: 33593906; PMCID: PMC7923669.
Khalid S, Keller NP. Chemical signals driving bacterial-fungal interactions. Environ Microbiol. 2021 Jan 28. doi: 10.1111/1462-2920.15410. Epub ahead of print. PMID: 33511714.
Zelante, T., Choera, T., Beauvais, A., Fallarino, F., Paolicelli, G., Pieraccini, G., Pieroni, M., Galosi, C., Beato, C., De Luca, A., Boscaro, F., Romoli, R., Liu, X., Warris, A., Verweij, P. E., Ballard, E., Borghi, M., Pariano, M., Costantino, G., Calvitti, M., … Romani, L. (2021). Aspergillus fumigatus tryptophan metabolic route differently affects host immunity. Cell reports, 34(4), 108673. https://doi.org/10.1016/j.celrep.2020.108673
Pierce, E. C., Morin, M., Little, J. C., Liu, R. B., Tannous, J., Keller, N. P., Pogliano, K., Wolfe, B. E., Sanchez, L. M., & Dutton, R. J. (2020). Bacterial-fungal interactions revealed by genome-wide analysis of bacterial mutant fitness. Nature microbiology, 10.1038/s41564-020-00800-z. Advance online publication. https://doi.org/10.1038/s41564-020-00800-z
Steffan, B. N., Venkatesh, N., & Keller, N. P. (2020). Let's Get Physical: Bacterial-Fungal Interactions and Their Consequences in Agriculture and Health. Journal of fungi (Basel, Switzerland), 6(4), E243. https://doi.org/10.3390/jof6040243
Niu, M., Steffan, B. N., Fischer, G. J., Venkatesh, N., Raffa, N. L., Wettstein, M. A., Bok, J. W., Greco, C., Zhao, C., Berthier, E., Oliw, E., Beebe, D., Bromley, M., & Keller, N. P. (2020). Fungal oxylipins direct programmed developmental switches in filamentous fungi. Nature communications, 11(1), 5158. https://doi.org/10.1038/s41467-020-18999-0
Caesar, L. K., Kelleher, N. L., & Keller, N. P. (2020). In the fungus where it happens: History and future propelling Aspergillus nidulans as the archetype of natural products research. Fungal genetics and biology : FG & B, 144, 103477. Advance online publication. https://doi.org/10.1016/j.fgb.2020.103477
Luciano-Rosario, D., Keller, N. P., & Jurick, W. M., 2nd (2020). Penicillium expansum: biology, omics, and management tools for a global postharvest pathogen causing blue mould of pome fruit. Molecular plant pathology, 21(11), 1391–1404. https://doi.org/10.1111/mpp.12990
Caesar, L. K., Robey, M. T., Swyers, M., Islam, M. N., Ye, R., Vagadia, P. P., Schiltz, G. E., Thomas, P. M., Wu, C. C., Kelleher, N. L., Keller, N. P., & Bok, J. W. (2020). Heterologous Expression of the Unusual Terreazepine Biosynthetic Gene Cluster Reveals a Promising Approach for Identifying New Chemical Scaffolds. mBio, 11(4), e01691-20. https://doi.org/10.1128/mBio.01691-20
Chen, L., Qu, S., Yang, K., Liu, M., Li, Y. X., Keller, N. P., Zeng, X., & Tian, J. (2020). Perillaldehyde: A promising antifungal agent to treat oropharyngeal candidiasis. Biochemical pharmacology, 180, 114201. https://doi.org/10.1016/j.bcp.2020.114201
Rush, T. A., Puech-Pagès, V., Bascaules, A., Jargeat, P., Maillet, F., Haouy, A., Maës, A. Q., Carriel, C. C., Khokhani, D., Keller-Pearson, M., Tannous, J., Cope, K. R., Garcia, K., Maeda, J., Johnson, C., Kleven, B., Choudhury, Q. J., Labbé, J., Swift, C., O'Malley, M. A., … Ané, J. M. (2020). Lipo-chitooligosaccharides as regulatory signals of fungal growth and development. Nature communications, 11(1), 3897. https://doi.org/10.1038/s41467-020-17615-5
Liu, X., Jiang, Y., He, D., Fang, X., Xu, J., Lee, Y. W., Keller, N. P., & Shi, J. (2020). Copper Tolerance Mediated by FgAceA and FgCrpA in Fusarium graminearum. Frontiers in microbiology, 11, 1392. https://doi.org/10.3389/fmicb.2020.01392
Drott, M. T., Satterlee, T. R., Skerker, J. M., Pfannenstiel, B. T., Glass, N. L., Keller, N. P., & Milgroom, M. G. (2020). The Frequency of Sex: Population Genomics Reveals Differences in Recombination and Population Structure of the Aflatoxin-Producing Fungus Aspergillus flavus. mBio, 11(4), e00963-20. https://doi.org/10.1128/mBio.00963-20
Liu, X., Jiang, Y., He, D., Fang, X., Xu, J., Lee, Y. W., Keller, N. P., & Shi, J. (2020). Copper Tolerance Mediated by FgAceA and FgCrpA in Fusarium graminearum. Frontiers in microbiology, 11, 1392. https://doi.org/10.3389/fmicb.2020.01392
McGenity, T. J., Gessesse, A., Hallsworth, J. E., Garcia Cela, E., Verheecke-Vaessen, C., Wang, F., Chavarría, M., Haggblom, M. M., Molin, S., Danchin, A., Smid, E. J., Lood, C., Cockell, C. S., Whitby, C., Liu, S. J., Keller, N. P., Stein, L. Y., Bordenstein, S. R., Lal, R., Nunes, O. C., … Timmis, K. (2020). Visualizing the invisible: class excursions to ignite children's enthusiasm for microbes. Microbial biotechnology, 13(4), 844–887. https://doi.org/10.1111/1751-7915.13576
Tannous, J., Barda, O., Luciano-Rosario, D., Prusky, D. B., Sionov, E., & Keller, N. P. (2020). New Insight Into Pathogenicity and Secondary Metabolism of the Plant Pathogen Penicillium expansum Through Deletion of the Epigenetic Reader SntB. Frontiers in microbiology, 11, 610. https://doi.org/10.3389/fmicb.2020.00610
Drott, M. T., Bastos, R. W., Rokas, A., Ries, L., Gabaldón, T., Goldman, G. H., Keller, N. P., & Greco, C. (2020). Diversity of Secondary Metabolism in Aspergillus nidulans Clinical Isolates. mSphere, 5(2), e00156-20. https://doi.org/10.1128/mSphere.00156-20
Bastos, R. W., Valero, C., Silva, L. P., Schoen, T., Drott, M., Brauer, V., Silva-Rocha, R., Lind, A., Steenwyk, J. L., Rokas, A., Rodrigues, F., Resendiz-Sharpe, A., Lagrou, K., Marcet-Houben, M., Gabaldón, T., McDonnell, E., Reid, I., Tsang, A., Oakley, B. R., Loures, F. V., … Goldman, G. H. (2020). Functional Characterization of Clinical Isolates of the Opportunistic Fungal Pathogen Aspergillus nidulans. mSphere, 5(2), e00153-20. https://doi.org/10.1128/mSphere.00153-20
Meyer, V., Basenko, E. Y., Benz, J. P., Braus, G. H., Caddick, M. X., Csukai, M., de Vries, R. P., Endy, D., Frisvad, J. C., Gunde-Cimerman, N., Haarmann, T., Hadar, Y., Hansen, K., Johnson, R. I., Keller, N. P., Kraševec, N., Mortensen, U. H., Perez, R., Ram, A., Record, E., … Wösten, H. (2020). Growing a circular economy with fungal biotechnology: a white paper. Fungal biology and biotechnology, 7, 5. https://doi.org/10.1186/s40694-020-00095-z
Wiesner, D. L., Merkhofer, R. M., Ober, C., Kujoth, G. C., Niu, M., Keller, N. P., Gern, J. E., Brockman-Schneider, R. A., Evans, M. D., Jackson, D. J., Warner, T., Jarjour, N. N., Esnault, S. J., Feldman, M. B., Freeman, M., Mou, H., Vyas, J. M., & Klein, B. S. (2020). Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation. Cell host & microbe, 27(4), 614–628.e6. https://doi.org/10.1016/j.chom.2020.02.006
Frawley, D., Greco, C., Oakley, B., Alhussain, M. M., Fleming, A. B., Keller, N. P., & Bayram, Ö. (2020). The tetrameric pheromone module SteC-MkkB-MpkB-SteD regulates asexual sporulation, sclerotia formation and aflatoxin production in Aspergillus flavus. Cellular microbiology, 22(6), e13192. https://doi.org/10.1111/cmi.13192
Blachowicz, A., Raffa N., Bok, J., Choera, T., Knox, B., Lim, F., Huttenlocher, A., Wang, C., Venkateswaran, K., Keller, N., (2020). Contributions of Spore Secondary Metabolites to UV-C Protection and Virulence Vary in Different Aspergillus fumigatus Strains. mBio. DOI: 10.1128/mBio.03415-19
Baccile J., Le, H., Pfannenstiel, B., Bok, J., Gomez, C., Brandenburger, E., Hoffmeister, D., Keller, N., Schroeder, F. (2019). Diketopiperazine Formation in Fungi Requires Dedicated Cyclization and Thiolation Domains. Angewandte Chemie 58(41).
Greco, C., Keller, N. P. , Rokas, A., Unearthing fungal chemodiversity and prospects for drug discovery, (2019), Curr Opin Microbiol. 51:22-29
Niu, M., and Keller, N.P. (2019). Co-opting oxylipin signals in microbial disease. Cell Microbiol 6.
Greco, C., Pfannenstiel, B.T., Liu, J.C. and Keller, N.P. (2019). Depsipeptide Aspergillicins Revealed by Chromatin Reader Protein Deletion. ACS Chem Biol 14:6:1121-1128
· Raffa, N., and Keller, N.P. (2019). A call to arms: Mustering secondary metabolites for success and survival of an opportunistic pathogen. PLoS Pathog 15.
· Venkatesh, N., and Keller, N.P. (2019). Mycotoxins in Conversation With Bacteria and Fungi. Front Microbiol 10.
· Rosowski EE, Knox BP, Archambault LS, Huttenlocher A, Keller NP, Wheeler RT, Davis JM , The Zebrafish as a Model Host for Invasive Fungal Infections, J Fungi (Basel). 2018 Dec 13;4(4). pii: E136. doi: 10.3390/jof4040136
· Dindo M, Costanzi E, Pieroni M, Costantini C, Annunziato G, Bruno A, Keller NP, Romani L, Zelante T, Cellini B, Biochemical Characterization of Aspergillus fumigatus AroH, a Putative Aromatic Amino Acid Aminotransferase, Front Mol Biosci. 2018 Nov 28;5:104. doi: 10.3389/fmolb.2018.00104
· N. P. K Keller, Fungal secondary metabolism: regulation, function and drug discovery, Nat Rev Microbiol. 2018 Dec 10. doi: 10.1038/s41579-018-0121-
· Guruceaga X, Ezpeleta G, Mayayo E, Sueiro-Olivares M, Abad-Diaz-De-Cerio A, Aguirre Urízar JM, Liu HG, Wiemann P, Bok JW, Filler SG, Keller NP, Hernando FL, Ramirez-Garcia A, Rementeria A.; A possible role for fumagillin in cellular damage during host infection by Aspergillus fumigatus;. Virulence. 2018;9(1):1548-1561. doi: 10.1080/21505594.2018.1526528.
· Pfannenstiel BT, Greco C, Sukowaty AT, Keller NP (2018) The epigenetic reader SntB regulates secondary metabolism, development and global histone modifications in Aspergillus flavus. Fungal Genet. Biol. 120:9-18
· Zhao X, Zhi QQ, Li JY, Keller NP, He ZM (2018) The Antioxidant Gallic Acid Inhibits Aflatoxin Formation in by Modulating Transcription Factors FarB and CreA. Toxins (Basel) 10(7):
· Jain S, Wiemann P, Thill E, Williams B, Keller NP, Kabbage M (2018) A Bcl-2 Associated Athanogene (bagA) Modulates Sexual Development and Secondary Metabolism in the Filamentous Fungus . Front Microbiol 9:1316 (PMC6013550)
· Lin H, Lyu H, Zhou S, Yu J, Keller NP, Chen L, Yin WB (2018) Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans. Org. Biomol. Chem. 16(27):4973-4976 ·
· Lim FY, Won TH, Raffa N, Baccile JA, Wisecaver J, Rokas A, Schroeder FC, Keller NP (2018) Fungal Isocyanide Synthases and Xanthocillin Biosynthesis in Aspergillus fumigatus. MBio 9(3): (PMC5974471) ·
· Rank LA, Walsh NM, Lim FY, Gellman SH, Keller NP, Hull CM (2018) Peptide-Like Nylon-3 Polymers with Activity against Phylogenetically Diverse, Intrinsically Drug-Resistant Pathogenic Fungi. mSphere 3(3): (PMC5967195) ·
· Spraker JE, Wiemann P, Baccile JA, Venkatesh N, Schumacher J, Schroeder FC, Sanchez LM, Keller NP (2018) Conserved Responses in a War of Small Molecules between a Plant-Pathogenic Bacterium and Fungi. MBio 9(3): (PMC5964348) ·
· Jain S, Sekonyela R, Knox BP, Palmer JM, Huttenlocher A, Kabbage M, Keller NP (2018) Selenate sensitivity of a laeA mutant is restored by overexpression of the bZIP protein MetR in Aspergillus fumigatus. Fungal Genet. Biol. 117:1-10 ·
· Molnár ÁP, Németh Z, Fekete E, Flipphi M, Keller NP, Karaffa L (2018) Analysis of the Relationship between Alternative Respiration and Sterigmatocystin Formation in . Toxins (Basel) 10(4): (PMC5923334) ·
· Robey MT, Ye R, Bok JW, Clevenger KD, Islam MN, Chen C, Gupta R, Swyers M, Wu E, Gao P, Thomas PM, Wu CC, Keller NP, Kelleher NL (2018) Identification of the First Diketomorpholine Biosynthetic Pathway Using FAC-MS Technology. ACS Chem. Biol. 13(5):1142-1147 (PMC5959802) ·
· Lind AL, Lim FY, Soukup AA, Keller NP, Rokas A (2018) An LaeA- and BrlA-Dependent Cellular Network Governs Tissue-Specific Secondary Metabolism in the Human Pathogen . mSphere 3(2): (PMC5853485) ·
· Wiemann P, Soukup AA, Folz JS, Wang PM, Noack A, Keller NP (2018) CoIN: co-inducible nitrate expression system for secondary metabolites in . Fungal Biol Biotechnol 5:6 (PMC5851313) ·
· Clevenger KD, Ye R, Bok JW, Thomas PM, Islam MN, Miley GP, Robey MT, Chen C, Yang K, Swyers M, Wu E, Gao P, Wu CC, Keller NP, Kelleher NL (2018) Interrogation of Benzomalvin Biosynthesis Using Fungal Artificial Chromosomes with Metabolomic Scoring (FAC-MS): Discovery of a Benzodiazepine Synthase Activity. Biochemistry 57(23):3237-3243 (PMC5997561) ·
· Choera T, Zelante T, Romani L, Keller NP (2018) A Multifaceted Role of Tryptophan Metabolism and Indoleamine 2,3-Dioxygenase Activity in -Host Interactions. Front Immunol 8:1996 (PMC5786828) ·
· Khalid S, Baccile JA, Spraker JE, Tannous J, Imran M, Schroeder FC, Keller NP (2017) NRPS-Derived Isoquinolines and Lipopetides Mediate Antagonism between Plant Pathogenic Fungi and Bacteria. ACS Chem. Biol. 13(1):171-179 (PMC5922988) ·
· Barkal LJ, Procknow CL, Álvarez-García YR, Niu M, Jiménez-Torres JA, Brockman-Schneider RA, Gern JE, Denlinger LC, Theberge AB, Keller NP, Berthier E, Beebe DJ (2017) Microbial volatile communication in human organotypic lung models. Nat Commun 8(1):1770 (PMC5701243) ·
· Lind AL, Wisecaver JH, Lameiras C, Wiemann P, Palmer JM, Keller NP, Rodrigues F, Goldman GH, Rokas A (2017) Drivers of genetic diversity in secondary metabolic gene clusters within a fungal species. PLoS Biol. 15(11):e2003583 (PMC5711037) ·
· Zhao X, Spraker JE, Bok JW, Velk T, He ZM, Keller NP (2017) A Cellular Fusion Cascade Regulated by LaeA Is Required for Sclerotial Development in . Front Microbiol 8:1925 (PMC5633613) ·
· Kumar D, Barad S, Sionov E, Keller NP, Prusky DB (2017) Does the Host Contribute to Modulation of Mycotoxin Production by Fruit Pathogens? Toxins (Basel) 9(9): (PMC5618213) ·
· Pfannenstiel BT, Zhao X, Wortman J, Wiemann P, Throckmorton K, Spraker JE, Soukup AA, Luo X, Lindner DL, Lim FY, Knox BP, Haas B, Fischer GJ, Choera T, Butchko RAE, Bok JW, Affeldt KJ, Keller NP, Palmer JM (2017) Revitalization of a Forward Genetic Screen Identifies Three New Regulators of Fungal Secondary Metabolism in the Genus . MBio 8(5): (PMC5587912) ·
· Barkal LJ, Berthier E, Theberge AB, Keller NP, Beebe DJ (2017) Multikingdom microscale models. PLoS Pathog. 13(8):e1006424 (PMC5570211) ·
· Rank LA, Walsh NM, Liu R, Lim FY, Bok JW, Huang M, Keller NP, Gellman SH, Hull CM (2017) A Cationic Polymer That Shows High Antifungal Activity against Diverse Human Pathogens. Antimicrob. Agents Chemother. 61(10): (PMC5610528) ·
· Clevenger KD, Bok JW, Ye R, Miley GP, Verdan MH, Velk T, Chen C, Yang K, Robey MT, Gao P, Lamprecht M, Thomas PM, Islam MN, Palmer JM, Wu CC, Keller NP, Kelleher NL (2017) A scalable platform to identify fungal secondary metabolites and their gene clusters. Nat. Chem. Biol. 13(8):895-901 (PMC5577364) ·
· Wiemann P, Perevitsky A, Lim FY, Shadkchan Y, Knox BP, Landero Figueora JA, Choera T, Niu M, Steinberger AJ, Wüthrich M, Idol RA, Klein BS, Dinauer MC, Huttenlocher A, Osherov N, Keller NP (2017) Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense. Cell Rep 19(10):2174-2176 ·
· Knox BP, Huttenlocher A, Keller NP (2017) Real-time visualization of immune cell clearance of Aspergillus fumigatus spores and hyphae. Fungal Genet. Biol. 105:52-54 (PMC5589445) ·
· Fischer GJ, Bacon W, Yang J, Palmer JM, Dagenais T, Hammock BD, Keller NP (2017) Lipoxygenase Activity Accelerates Programmed Spore Germination in . Front Microbiol 8:831 (PMC5422543) ·
· Zhang P, Wang X, Fan A, Zheng Y, Liu X, Wang S, Zou H, Oakley BR, Keller NP, Yin WB (2017) A cryptic pigment biosynthetic pathway uncovered by heterologous expression is essential for conidial development in Pestalotiopsis fici. Mol. Microbiol. 105(3):469-483 ·
· Wiemann P, Perevitsky A, Lim FY, Shadkchan Y, Knox BP, Landero Figueora JA, Choera T, Niu M, Steinberger AJ, Wüthrich M, Idol RA, Klein BS, Dinauer MC, Huttenlocher A, Osherov N, Keller NP (2017) Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense. Cell Rep 19(5):1008-1021 (PMC5512462) ·
· Tannous J, Keller NP, Atoui A, El Khoury A, Lteif R, Oswald IP, Puel O (2017) Secondary metabolism in Penicillium expansum: Emphasis on recent advances in patulin research. Crit Rev Food Sci Nutr :1-17 ·
· Vargas-Muñiz JM, Renshaw H, Waitt G, Soderblom EJ, Moseley MA, Palmer JM, Juvvadi PR, Keller NP, Steinbach WJ (2017) Caspofungin exposure alters the core septin AspB interactome of Aspergillus fumigatus. Biochem. Biophys. Res. Commun. 485(2):221-226 (PMC5384791) ·
· Keller NP (2017) Heterogeneity Confounds Establishment of "a" Model Microbial Strain. MBio 8(1): (PMC5358909) ·
· Soukup AA, Fischer GJ, Luo J, Keller NP (2017) The Aspergillus nidulans Pbp1 homolog is required for normal sexual development and secondary metabolism. Fungal Genet. Biol. 100:13-21 (PMC5337145) ·
· Bignell E, Cairns TC, Throckmorton K, Nierman WC, Keller NP (2017) Secondary metabolite arsenal of an opportunistic pathogenic fungus. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 371(1709): (PMC5095546) ·
· Németh Z, Molnár ÁP, Fejes B, Novák L, Karaffa L, Keller NP, Fekete E (2016) Growth-Phase Sterigmatocystin Formation on Lactose Is Mediated via Low Specific Growth Rates in Aspergillus nidulans. Toxins (Basel) 8(12): (PMC5198170) ·
· Clevenger KD, Bok JW, Ye R, Miley GP, Velk T, Chen C, Yang K, Gao P, Lamprecht M, Thomas PM, Islam MN, Wu CC, Keller NP, Kelleher NL (2016) Large scale discovery and deorphanization of natural products using fungal artificial chromosomes and untargeted metabolomics (FAC-MS). Planta Med. 81(S 01):S1-S381 ·
· Rosowski EE, Deng Q, Keller NP, Huttenlocher A (2016) Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. J. Immunol. 197(12):4780-4790 (PMC5367389) ·
· Knox BP, Blachowicz A, Palmer JM, Romsdahl J, Huttenlocher A, Wang CC, Keller NP, Venkateswaran K (2016) Characterization of Aspergillus fumigatus Isolates from Air and Surfaces of the International Space Station. mSphere 1(5): (PMC5082629) ·
· Luo X, Affeldt KJ, Keller NP (2016) Characterization of the Far Transcription Factor Family in Aspergillus flavus. G3 (Bethesda) 6(10):3269-3281 (PMC5068947) ·
· Drees KP, Palmer JM, Sebra R, Lorch JM, Chen C, Wu CC, Bok JW, Keller NP, Blehert DS, Cuomo CA, Lindner DL, Foster JT(2016) Use of Multiple Sequencing Technologies To Produce a High-Quality Genome of the Fungus Pseudogymnoascus destructans, the Causative Agent of Bat White-Nose Syndrome. Genome Announc 4(3): (PMC4929507) ·
· Henke MT, Soukup AA, Goering AW, McClure RA, Thomson RJ, Keller NP, Kelleher NL (2016) New Aspercryptins, Lipopeptide Natural Products, Revealed by HDAC Inhibition in Aspergillus nidulans. ACS Chem. Biol. 11(8):2117-23 (PMC5119465) ·
· Yeh HH, Ahuja M, Chiang YM, Oakley CE, Moore S, Yoon O, Hajovsky H, Bok JW, Keller NP, Wang CC, Oakley BR (2016) Resistance Gene-Guided Genome Mining: Serial Promoter Exchanges in Aspergillus nidulans Reveal the Biosynthetic Pathway for Fellutamide B, a Proteasome Inhibitor. ACS Chem. Biol. 11(8):2275-84 ·
· Baccile JA, Spraker JE, Le HH, Brandenburger E, Gomez C, Bok JW, Macheleidt J, Brakhage AA, Hoffmeister D, Keller NP, Schroeder FC (2016) Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus. Nat. Chem. Biol. 12(6):419-24 (PMC5049701) ·
· Kerr SC, Fischer GJ, Sinha M, McCabe O, Palmer JM, Choera T, Lim FY, Wimmerova M, Carrington SD, Yuan S, Lowell CA, Oscarson S, Keller NP, Fahy JV (2016) FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection. PLoS Pathog. 12(4):e1005555 (PMC4825926) ·
· Wu G, Zhou H, Zhang P, Wang X, Li W, Zhang W, Liu X, Liu HW, Keller NP, An Z, Yin WB (2016) Polyketide Production of Pestaloficiols and Macrodiolide Ficiolides Revealed by Manipulations of Epigenetic Regulators in an Endophytic Fungus. Org. Lett. 18(8):1832-5 ·
· Zhao Y, He M, Xi Q, Ding J, Hao B, Keller NP, Zheng W (2016) Reversible S-nitrosylation limits over synthesis of fungal styrylpyrone upon nitric oxide burst. Appl. Microbiol. Biotechnol. 100(9):4123-34 ·
· Spraker JE, Sanchez LM, Lowe TM, Dorrestein PC, Keller NP (2016) Ralstonia solanacearum lipopeptide induces chlamydospore development in fungi and facilitates bacterial entry into fungal tissues. ISME J 10(9):2317-30 (PMC4989320) ·
· Fischer GJ, Keller NP (2016) Production of cross-kingdom oxylipins by pathogenic fungi: An update on their role in development and pathogenicity. J. Microbiol. 54(3):254-64 (PMC5107414) ·
· Song J, Zhai P, Zhang Y, Zhang C, Sang H, Han G, Keller NP, Lu L (2016) The Aspergillus fumigatus Damage Resistance Protein Family Coordinately Regulates Ergosterol Biosynthesis and Azole Susceptibility. MBio 7(1):e01919-15 (PMC4791848) ·
· Barkal LJ, Theberge AB, Guo CJ, Spraker J, Rappert L, Berthier J, Brakke KA, Wang CC, Beebe DJ, Keller NP, Berthier E (2016) Microbial metabolomics in open microscale platforms. Nat Commun 7:10610 (PMC4742997) ·
· Soukup AA, Keller NP, Wiemann P (2016) Enhancing Nonribosomal Peptide Biosynthesis in Filamentous Fungi. Methods Mol. Biol. 1401:149-60 (PMC4773910) ·
· Wang PM, Choera T, Wiemann P, Pisithkul T, Amador-Noguez D, Keller NP (2015) TrpE feedback mutants reveal roadblocks and conduits toward increasing secondary metabolism in Aspergillus fumigatus. Fungal Genet. Biol. 89:102-113 (PMC4789178) ·
· Keller NP (2015) Translating biosynthetic gene clusters into fungal armor and weaponry. Nat. Chem. Biol. 11(9):671-7 (PMC4682562) ·
· Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO (2015) Minimum Information about a Biosynthetic Gene cluster. Nat. Chem. Biol. 11(9):625-31 ·
· Throckmorton K, Wiemann P, Keller NP (2015) Evolution of Chemical Diversity in a Group of Non-Reduced Polyketide Gene Clusters: Using Phylogenetics to Inform the Search for Novel Fungal Natural Products. Toxins (Basel) 7(9):3572-607 (PMC4591646) ·
· Throckmorton K, Lim FY, Kontoyiannis DP, Zheng W, Keller NP (2015) Redundant synthesis of a conidial polyketide by two distinct secondary metabolite clusters in Aspergillus fumigatus. Environ. Microbiol. 18(1):246-59 (PMC4750049) ·
· Wang X, Wu F, Liu L, Liu X, Che Y, Keller NP, Guo L, Yin WB (2015) The bZIP transcription factor PfZipA regulates secondary metabolism and oxidative stress response in the plant endophytic fungus Pestalotiopsis fici. Fungal Genet. Biol. 81:221-8 ·
· Albright JC, Henke MT, Soukup AA, McClure RA, Thomson RJ, Keller NP, Kelleher NL (2015) Large-scale metabolomics reveals a complex response of Aspergillus nidulans to epigenetic perturbation. ACS Chem. Biol. 10(6):1535-41 (PMC4475433) ·
· Zhao Y, Xi Q, Xu Q, He M, Ding J, Dai Y, Keller NP, Zheng W (2015) Correlation of nitric oxide produced by an inducible nitric oxide synthase-like protein with enhanced expression of the phenylpropanoid pathway in Inonotus obliquus cocultured with Phellinus morii. Appl. Microbiol. Biotechnol. 99(10):4361-72 ·
· Macheleidt J, Scherlach K, Neuwirth T, Schmidt-Heck W, Straßburger M, Spraker J, Baccile JA, Schroeder FC, Keller NP, Hertweck C, Heinekamp T, Brakhage AA (2015) Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus. Mol. Microbiol. 96(1):148-62 (PMC4425693) ·
· Bok JW, Ye R, Clevenger KD, Mead D, Wagner M, Krerowicz A, Albright JC, Goering AW, Thomas PM, Kelleher NL, Keller NP, Wu CC (2015) Fungal artificial chromosomes for mining of the fungal secondary metabolome. BMC Genomics 16:343 (PMC4413528) ·
· Zheng H, Kim J, Liew M, Yan JK, Herrera O, Bok JW, Kelleher NL, Keller NP, Wang Y (2015) Redox metabolites signal polymicrobial biofilm development via the NapA oxidative stress cascade in Aspergillus. Curr. Biol. 25(1):29-37 (PMC4286458) ·
· Tyler BM, Kale SD, Wang Q, Tao K, Clark HR, Drews K, Antignani V, Rumore A, Hayes T, Plett JM, Fudal I, Gu B, Chen Q, Affeldt KJ, Berthier E, Fischer GJ, Dou D, Shan W, Keller NP, Martin F, Rouxel T, Lawrence CB (2015) Microbe-Independent Entry of Oomycete RxLR Effectors and Fungal RxLR-Like Effectors Into Plant and Animal Cells Is Specific and Reproducible. Mol. Plant Microbe Interact. 2015(1):51-56 ·
· Bok JW, Wiemann P, Garvey GS, Lim FY, Haas B, Wortman J, Keller NP (2014) Illumina identification of RsrA, a conserved C2H2 transcription factor coordinating the NapA mediated oxidative stress signaling pathway in Aspergillus. BMC Genomics 15:1011 (PMC4252986) ·
· Wiemann P, Lechner BE, Baccile JA, Velk TA, Yin WB, Bok JW, Pakala S, Losada L, Nierman WC, Schroeder FC, Haas H, Keller NP (2014) Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus. Front Microbiol 5:530 (PMC4208449) ·
· Knox BP, Deng Q, Rood M, Eickhoff JC, Keller NP, Huttenlocher A (2014) Distinct innate immune phagocyte responses to Aspergillus fumigatus conidia and hyphae in zebrafish larvae. Eukaryotic Cell 13(10):1266-77 (PMC4187654) ·
· Lim FY, Keller NP (2014) Spatial and temporal control of fungal natural product synthesis. Nat Prod Rep 31(10):1277-86 (PMC4162804) ·
· Affeldt KJ, Carrig J, Amare M, Keller NP (2014) Global survey of canonical Aspergillus flavus G protein-coupled receptors. MBio 5(5):e01501-14 (PMC4205791) ·
· Lim FY, Ames B, Walsh CT, Keller NP (2014) Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus. Cell. Microbiol. 16(8):1267-83 (PMC4114987) ·
· Miyamoto K, Murakami T, Kakumyan P, Keller NP, Matsui K (2014) Formation of 1-octen-3-ol from Aspergillus flavus conidia is accelerated after disruption of cells independently of Ppo oxygenases, and is not a main cause of inhibition of germination. PeerJ 2:e395 (PMC4034645) ·
· Amare MG, Keller NP (2014) Molecular mechanisms of Aspergillus flavus secondary metabolism and development. Fungal Genet. Biol. 66:11-8 ·
· Spraker JE, Jewell K, Roze LV, Scherf J, Ndagano D, Beaudry R, Linz JE, Allen C, Keller NP (2014) A volatile relationship: profiling an inter-kingdom dialogue between two plant pathogens, Ralstonia Solanacearum and Aspergillus Flavus. J. Chem. Ecol. 40(5):502-13 ·
· Wiemann P, Keller NP (2014) Strategies for mining fungal natural products. J. Ind. Microbiol. Biotechnol. 41(2):301-13 ·
· Gauthier GM, Keller NP (2013) Crossover fungal pathogens: the biology and pathogenesis of fungi capable of crossing kingdoms to infect plants and humans. Fungal Genet. Biol. 61:146-57 ·
· Keller NP (2013) Fungal meningitis outbreak editorial. Fungal Genet. Biol. 61:142 ·
· Bok JW, Soukup AA, Chadwick E, Chiang YM, Wang CC, Keller NP (2013) VeA and MvlA repression of the cryptic orsellinic acid gene cluster in Aspergillus nidulans involves histone 3 acetylation. Mol. Microbiol. 89(5):963-74 (PMC3773851) ·
· Wiemann P, Guo CJ, Palmer JM, Sekonyela R, Wang CC, Keller NP (2013) Prototype of an intertwined secondary-metabolite supercluster. Proc. Natl. Acad. Sci. U.S.A. 110(42):17065-70 (PMC3801025) ·
· Amaike S, Affeldt KJ, Yin WB, Franke S, Choithani A, Keller NP (2013) The bZIP protein MeaB mediates virulence attributes in Aspergillus flavus. PLoS ONE 8(9):e74030 (PMC3767667) ·
· Tyler BM, Kale SD, Wang Q, Tao K, Clark HR, Drews K, Antignani V, Rumore A, Hayes T, Plett JM, Fudal I, Gu B, Chen Q, Affeldt KJ, Berthier E, Fischer GJ, Dou D, Shan W, Keller NP, Martin F, Rouxel T, Lawrence CB (2013) Microbe-independent entry of oomycete RxLR effectors and fungal RxLR-like effectors into plant and animal cells is specific and reproducible. Mol. Plant Microbe Interact. 26(6):611-6 (PMC3994703) ·
· Casavant BP, Berthier E, Theberge AB, Berthier J, Montanez-Sauri SI, Bischel LL, Brakke K, Hedman CJ, Bushman W, Keller NP, Beebe DJ (2013) Suspended microfluidics. Proc. Natl. Acad. Sci. U.S.A. 110(25):10111-6 (PMC3690848) ·
· Patananan AN, Palmer JM, Garvey GS, Keller NP, Clarke SG (2013) A novel automethylation reaction in the Aspergillus nidulans LaeA protein generates S-methylmethionine. J. Biol. Chem. 288(20):14032-45 (PMC3656261) ·
· Palmer JM, Bok JW, Lee S, Dagenais TR, Andes DR, Kontoyiannis DP, Keller NP (2013) Loss of CclA, required for histone 3 lysine 4 methylation, decreases growth but increases secondary metabolite production in Aspergillus fumigatus. PeerJ 1:e4 (PMC3629006) ·
· Sekonyela R, Palmer JM, Bok JW, Jain S, Berthier E, Forseth R, Schroeder F, Keller NP (2013) RsmA regulates Aspergillus fumigatus gliotoxin cluster metabolites including cyclo(L-Phe-L-Ser), a potential new diagnostic marker for invasive aspergillosis. PLoS ONE 8(5):e62591 (PMC3646020) ·
· Berthier E, Lim FY, Deng Q, Guo CJ, Kontoyiannis DP, Wang CC, Rindy J, Beebe DJ, Huttenlocher A, Keller NP (2013) Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites. PLoS Pathog. 9(4):e1003289 (PMC3623715) ·
· Berthier E, Guckenberger DJ, Cavnar P, Huttenlocher A, Keller NP, Beebe DJ (2013) Kit-On-A-Lid-Assays for accessible self-contained cell assays. Lab Chip 13(3):424-31 (PMC3562598) ·
· Yin WB, Baccile JA, Bok JW, Chen Y, Keller NP, Schroeder FC (2013) A nonribosomal peptide synthetase-derived iron(III) complex from the pathogenic fungus Aspergillus fumigatus. J. Am. Chem. Soc. 135(6):2064-7 (PMC3590312) ·
· Karimi-Aghcheh R, Bok JW, Phatale PA, Smith KM, Baker SE, Lichius A, Omann M, Zeilinger S, Seiboth B, Rhee C, Keller NP, Freitag M, Kubicek CP (2013) Functional analyses of Trichoderma reesei LAE1 reveal conserved and contrasting roles of this regulator. G3 (Bethesda) 3(2):369-78 (PMC3564997) ·
· Forseth RR, Amaike S, Schwenk D, Affeldt KJ, Hoffmeister D, Schroeder FC, Keller NP (2013) Homologous NRPS-like gene clusters mediate redundant small-molecule biosynthesis in Aspergillus flavus. Angew. Chem. Int. Ed. Engl. 52(5):1590-4 (PMC3758896) ·
· Yin WB, Reinke AW, Szilágyi M, Emri T, Chiang YM, Keating AE, Pócsi I, Wang CC, Keller NP (2013) bZIP transcription factors affecting secondary metabolism, sexual development and stress responses in Aspergillus nidulans. Microbiology (Reading, Engl.) 159(Pt 1):77-88 (PMC3542729) ·
· Palmer JM, Theisen JM, Duran RM, Grayburn WS, Calvo AM, Keller NP (2013) Secondary metabolism and development is mediated by LlmF control of VeA subcellular localization in Aspergillus nidulans. PLoS Genet. 9(1):e1003193 (PMC3547832) ·
· Soukup AA, Farnoodian M, Berthier E, Keller NP (2012) NosA, a transcription factor important in Aspergillus fumigatus stress and developmental response, rescues the germination defect of a laeA deletion. Fungal Genet. Biol. 49(11):857-65 (PMC3483426) ·
· Lim FY, Sanchez JF, Wang CC, Keller NP (2012) Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi. Meth. Enzymol. 517:303-24 ·
· Wang S, Cao J, Liu X, Hu H, Shi J, Zhang S, Keller NP, Lu L (2012) Putative calcium channels CchA and MidA play the important roles in conidiation, hyphal polarity and cell wall components in Aspergillus nidulans. PLoS ONE 7(10):e46564 (PMC3470553) ·
· Bok JW, Keller NP (2012) Fast and easy method for construction of plasmid vectors using modified quick-change mutagenesis. Methods Mol. Biol. 944:163-74 ·
· Soukup AA, Chiang YM, Bok JW, Reyes-Dominguez Y, Oakley BR, Wang CC, Strauss J, Keller NP (2012) Overexpression of the Aspergillus nidulans histone 4 acetyltransferase EsaA increases activation of secondary metabolite production. Mol. Microbiol. 86(2):314-30 (PMC3514908) ·
· Affeldt KJ, Brodhagen M, Keller NP (2012) Aspergillus oxylipin signaling and quorum sensing pathways depend on g protein-coupled receptors. Toxins (Basel) 4(9):695-717 (PMC3475224) ·
· Lim FY, Hou Y, Chen Y, Oh JH, Lee I, Bugni TS, Keller NP (2012) Genome-based cluster deletion reveals an endocrocin biosynthetic pathway in Aspergillus fumigatus. Appl. Environ. Microbiol. 78(12):4117-25 (PMC3370519) ·
· Yin WB, Amaike S, Wohlbach DJ, Gasch AP, Chiang YM, Wang CC, Bok JW, Rohlfs M, Keller NP (2012) An Aspergillus nidulans bZIP response pathway hardwired for defensive secondary metabolism operates through aflR. Mol. Microbiol. 83(5):1024-34 (PMC3288630) ·
· Sanchez JF, Somoza AD, Keller NP, Wang CC (2012) Advances in Aspergillus secondary metabolite research in the post-genomic era. Nat Prod Rep 29(3):351-71 ·
· Scherm B, Orrù M, Balmas V, Spanu F, Azara E, Delogu G, Hammond TM, Keller NP, Migheli Q (2011) Altered trichothecene biosynthesis in TRI6-silenced transformants of Fusarium culmorum influences the severity of crown and foot rot on durum wheat seedlings. Mol. Plant Pathol. 12(8):759-71 ·
· Amaike S, Keller NP (2011) Aspergillus flavus. Annu Rev Phytopathol 49:107-33 ·
· Yin W, Keller NP (2011) Transcriptional regulatory elements in fungal secondary metabolism. J. Microbiol. 49(3):329-39 ·
· Forseth RR, Fox EM, Chung D, Howlett BJ, Keller NP, Schroeder FC (2011) Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis. J. Am. Chem. Soc. 133(25):9678-81 (PMC3151163) ·
· Giles SS, Soukup AA, Lauer C, Shaaban M, Lin A, Oakley BR, Wang CC, Keller NP (2011) Cryptic Aspergillus nidulans antimicrobials. Appl. Environ. Microbiol. 77(11):3669-75 (PMC3127626) ·
· Keller NP, Bennett J, Turner G (2011) Secondary metabolism: then, now and tomorrow. Fungal Genet. Biol. 48(1):1-3 ·
· Shaaban MI, Bok JW, Lauer C, Keller NP (2010) Suppressor mutagenesis identifies a velvet complex remediator of Aspergillus nidulans secondary metabolism. Eukaryotic Cell 9(12):1816-24 (PMC3008278) ·
· Palmer JM, Mallaredy S, Perry DW, Sanchez JF, Theisen JM, Szewczyk E, Oakley BR, Wang CC, Keller NP, Mirabito PM (2010) Telomere position effect is regulated by heterochromatin-associated proteins and NkuA in Aspergillus nidulans. Microbiology (Reading, Engl.) 156(Pt 12):3522-31 (PMC3068700) ·
· Wilkinson HH, Ramaswamy A, Sim SC, Keller NP (2010) Increased conidiation associated with progression along the sterigmatocystin biosynthetic pathway. Mycologia 96(6):1190-8 ·
· Palmer JM, Keller NP (2010) Secondary metabolism in fungi: does chromosomal location matter? Curr. Opin. Microbiol. 13(4):431-6 (PMC2922032) ·
· Wiemann P, Brown DW, Kleigrewe K, Bok JW, Keller NP, Humpf HU, Tudzynski B (2010) FfVel1 and FfLae1, components of a velvet-like complex in Fusarium fujikuroi, affect differentiation, secondary metabolism and virulence. Mol. Microbiol. : (PMC2989987) ·
· Chiang YM, Oakley BR, Keller NP, Wang CC (2010) Unraveling polyketide synthesis in members of the genus Aspergillus. Appl. Microbiol. Biotechnol. 86(6):1719-36 (PMC3110678) ·
· Shaaban M, Palmer JM, El-Naggar WA, El-Sokkary MA, Habib el-SE, Keller NP (2010) Involvement of transposon-like elements in penicillin gene cluster regulation. Fungal Genet. Biol. 47(5):423-32 (PMC2863007) ·
· Chiang YM, Szewczyk E, Davidson AD, Entwistle R, Keller NP, Wang CC, Oakley BR (2010) Characterization of the Aspergillus nidulans monodictyphenone gene cluster. Appl. Environ. Microbiol. 76(7):2067-74 (PMC2849234) ·
· Georgianna DR, Fedorova ND, Burroughs JL, Dolezal AL, Bok JW, Horowitz-Brown S, Woloshuk CP, Yu J, Keller NP, Payne GA(2010) Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters. Mol. Plant Pathol. 11(2):213-26 ·
· Dagenais TR, Giles SS, Aimanianda V, Latgé JP, Hull CM, Keller NP (2010) Aspergillus fumigatus LaeA-mediated phagocytosis is associated with a decreased hydrophobin layer. Infect. Immun. 78(2):823-9 (PMC2812189) ·
· Chiang YM, Lee KH, Sanchez JF, Keller NP, Wang CC (2009) Unlocking fungal cryptic natural products. Nat Prod Commun 4(11):1505-10 (PMC3101174) ·
· Lee I, Oh JH, Shwab EK, Dagenais TR, Andes D, Keller NP (2009) HdaA, a class 2 histone deacetylase of Aspergillus fumigatus, affects germination and secondary metabolite production. Fungal Genet. Biol. 46(10):782-90 (PMC2755195) ·
· Giles SS, Dagenais TR, Botts MR, Keller NP, Hull CM (2009) Elucidating the pathogenesis of spores from the human fungal pathogen Cryptococcus neoformans. Infect. Immun. 77(8):3491-500 (PMC2715683) ·
· Dagenais TR, Keller NP (2009) Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis. Clin. Microbiol. Rev. 22(3):447-65 (PMC2708386) ·
· Brown SH, Scott JB, Bhaheetharan J, Sharpee WC, Milde L, Wilson RA, Keller NP (2009) Oxygenase coordination is required for morphological transition and the host-fungus interaction of Aspergillus flavus. Mol. Plant Microbe Interact. 22(7):882-94 ·
· Bok JW, Chiang YM, Szewczyk E, Reyes-Dominguez Y, Davidson AD, Sanchez JF, Lo HC, Watanabe K, Strauss J, Oakley BR, Wang CC, Keller NP (2009) Chromatin-level regulation of biosynthetic gene clusters. Nat. Chem. Biol. 5(7):462-4 (PMC2891026) ·
· Amaike S, Keller NP (2009) Distinct roles for VeA and LaeA in development and pathogenesis of Aspergillus flavus. Eukaryotic Cell 8(7):1051-60 (PMC2708460) ·
· Gao X, Brodhagen M, Isakeit T, Brown SH, Göbel C, Betran J, Feussner I, Keller NP, Kolomiets MV (2009) Inactivation of the lipoxygenase ZmLOX3 increases susceptibility of maize to Aspergillus spp. Mol. Plant Microbe Interact. 22(2):222-31 ·
· Bok JW, Keller NP, Tsitsigiannis DI (2008) Real-time and semiquantitative RT-PCR methods to analyze gene expression patterns during Aspergillus-host interactions. Methods Mol. Biol. 470:151-67 ·
· Palmer JM, Perrin RM, Dagenais TR, Keller NP (2008) H3K9 methylation regulates growth and development in Aspergillus fumigatus. Eukaryotic Cell 7(12):2052-60 (PMC2593193) ·
· Kale SP, Milde L, Trapp MK, Frisvad JC, Keller NP, Bok JW (2008) Requirement of LaeA for secondary metabolism and sclerotial production in Aspergillus flavus. Fungal Genet. Biol. 45(10):1422-9 (PMC2845523) ·
· Horowitz Brown S, Zarnowski R, Sharpee WC, Keller NP (2008) Morphological transitions governed by density dependence and lipoxygenase activity in Aspergillus flavus. Appl. Environ. Microbiol. 74(18):5674-85 (PMC2547031) ·
· Dagenais TR, Chung D, Giles SS, Hull CM, Andes D, Keller NP (2008) Defects in conidiophore development and conidium-macrophage interactions in a dioxygenase mutant of Aspergillus fumigatus. Infect. Immun. 76(7):3214-20 (PMC2446696) ·
· Bayram O, Krappmann S, Ni M, Bok JW, Helmstaedt K, Valerius O, Braus-Stromeyer S, Kwon NJ, Keller NP, Yu JH, Braus GH(2008) VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science 320(5882):1504-6 ·
· Fox EM, Gardiner DM, Keller NP, Howlett BJ (2008) A Zn(II)2Cys6 DNA binding protein regulates the sirodesmin PL biosynthetic gene cluster in Leptosphaeria maculans. Fungal Genet. Biol. 45(5):671-82 (PMC2399893) ·
· Maggio-Hall LA, Lyne P, Wolff JA, Keller NP (2008) A single acyl-CoA dehydrogenase is required for catabolism of isoleucine, valine and short-chain fatty acids in Aspergillus nidulans. Fungal Genet. Biol. 45(3):180-9 (PMC2905684) ·
· Stadler M, Keller NP (2008) Paradigm shifts in fungal secondary metabolite research. Mycol. Res. 112(Pt 2):127-30 ·
· Shwab EK, Keller NP (2008) Regulation of secondary metabolite production in filamentous ascomycetes. Mycol. Res. 112(Pt 2):225-30 ·
· Hammond TM, Bok JW, Andrewski MD, Reyes-Domínguez Y, Scazzocchio C, Keller NP (2008) RNA silencing gene truncation in the filamentous fungus Aspergillus nidulans. Eukaryotic Cell 7(2):339-49 (PMC2238149) ·
· Hammond TM, Andrewski MD, Roossinck MJ, Keller NP (2008) Aspergillus mycoviruses are targets and suppressors of RNA silencing. Eukaryotic Cell 7(2):350-7 (PMC2238147) ·
· Brodhagen M, Tsitsigiannis DI, Hornung E, Goebel C, Feussner I, Keller NP (2008) Reciprocal oxylipin-mediated cross-talk in the Aspergillus-seed pathosystem. Mol. Microbiol. 67(2):378-91 ·
· Garscha U, Jernerén F, Chung D, Keller NP, Hamberg M, Oliw EH (2007) Identification of dioxygenases required for Aspergillus development. Studies of products, stereochemistry, and the reaction mechanism. J. Biol. Chem. 282(48):34707-18 ·
· Bouhired S, Weber M, Kempf-Sontag A, Keller NP, Hoffmeister D (2007) Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA. Fungal Genet. Biol. 44(11):1134-45 ·
· Rohlfs M, Albert M, Keller NP, Kempken F (2007) Secondary chemicals protect mould from fungivory. Biol. Lett. 3(5):523-5 (PMC2391202) ·
· Shwab EK, Bok JW, Tribus M, Galehr J, Graessle S, Keller NP (2007) Histone deacetylase activity regulates chemical diversity in Aspergillus. Eukaryotic Cell 6(9):1656-64 (PMC2043372) ·
· Perrin RM, Fedorova ND, Bok JW, Cramer RA, Wortman JR, Kim HS, Nierman WC, Keller NP (2007) Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA. PLoS Pathog. 3(4):e50 (PMC1851976) ·
· Hoffmeister D, Keller NP (2007) Natural products of filamentous fungi: enzymes, genes, and their regulation. Nat Prod Rep 24(2):393-416 ·
· Tsitsigiannis DI, Keller NP (2007) Oxylipins as developmental and host-fungal communication signals. Trends Microbiol. 15(3):109-18 ·
· Bok JW, Chung D, Balajee SA, Marr KA, Andes D, Nielsen KF, Frisvad JC, Kirby KA, Keller NP (2006) GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence. Infect. Immun. 74(12):6761-8 (PMC1698057) ·
· Bok JW, Noordermeer D, Kale SP, Keller NP (2006) Secondary metabolic gene cluster silencing in Aspergillus nidulans. Mol. Microbiol. 61(6):1636-45 ·
· Brodhagen M, Keller NP (2006) Signalling pathways connecting mycotoxin production and sporulation. Mol. Plant Pathol. 7(4):285-301 ·
· Tsitsigiannis DI, Keller NP (2006) Oxylipins act as determinants of natural product biosynthesis and seed colonization in Aspergillus nidulans. Mol. Microbiol. 59(3):882-92 ·
· Bok JW, Hoffmeister D, Maggio-Hall LA, Murillo R, Glasner JD, Keller NP (2006) Genomic mining for Aspergillus natural products. Chem. Biol. 13(1):31-7 ·
· Keller NP, Turner G, Bennett JW (2005) Fungal secondary metabolism - from biochemistry to genomics. Nat. Rev. Microbiol. 3(12):937-47 ·
· Tsitsigiannis DI, Kunze S, Willis DK, Feussner I, Keller NP (2005) Aspergillus infection inhibits the expression of peanut 13S-HPODE-forming seed lipoxygenases. Mol. Plant Microbe Interact. 18(10):1081-9 ·
· Bok JW, Balajee SA, Marr KA, Andes D, Nielsen KF, Frisvad JC, Keller NP (2005) LaeA, a regulator of morphogenetic fungal virulence factors. Eukaryotic Cell 4(9):1574-82 (PMC1214197) ·
· Maggio-Hall LA, Wilson RA, Keller NP (2005) Fundamental contribution of beta-oxidation to polyketide mycotoxin production in planta. Mol. Plant Microbe Interact. 18(8):783-93 ·
· Tsitsigiannis DI, Bok JW, Andes D, Nielsen KF, Frisvad JC, Keller NP (2005) Aspergillus cyclooxygenase-like enzymes are associated with prostaglandin production and virulence. Infect. Immun. 73(8):4548-59 (PMC1201276) ·
· McDonald T, Brown D, Keller NP, Hammond TM (2005) RNA silencing of mycotoxin production in Aspergillus and Fusarium species. Mol. Plant Microbe Interact. 18(6):539-45 ·
· Tsitsigiannis DI, Kowieski TM, Zarnowski R, Keller NP (2005) Three putative oxylipin biosynthetic genes integrate sexual and asexual development in Aspergillus nidulans. Microbiology (Reading, Engl.) 151(Pt 6):1809-21 ·
· Hammond TM, Keller NP (2005) RNA silencing in Aspergillus nidulans is independent of RNA-dependent RNA polymerases. Genetics 169(2):607-17 (PMC1449118) ·
· Tsitsigiannis DI, Kowieski TM, Zarnowski R, Keller NP (2004) Endogenous lipogenic regulators of spore balance in Aspergillus nidulans. Eukaryotic Cell 3(6):1398-411 (PMC539017) ·
· Maggio-Hall LA, Keller NP (2004) Mitochondrial beta-oxidation in Aspergillus nidulans. Mol. Microbiol. 54(5):1173-85 ·
· Chang PK, Wilson RA, Keller NP, Cleveland TE (2004) Deletion of the Delta12-oleic acid desaturase gene of a nonaflatoxigenic Aspergillus parasiticus field isolate affects conidiation and sclerotial development. J. Appl. Microbiol. 97(6):1178-84 ·
· Zhang YQ, Brock M, Keller NP (2004) Connection of propionyl-CoA metabolism to polyketide biosynthesis in Aspergillus nidulans. Genetics 168(2):785-94 (PMC1448837) ·
· Wilson RA, Calvo AM, Chang PK, Keller NP (2004) Characterization of the Aspergillus parasiticus delta12-desaturase gene: a role for lipid metabolism in the Aspergillus-seed interaction. Microbiology (Reading, Engl.) 150(Pt 9):2881-8 ·
· Roze LV, Beaudry RM, Keller NP, Linz JE (2004) Regulation of aflatoxin synthesis by FadA/cAMP/protein kinase A signaling in Aspergillus parasiticus. Mycopathologia 158(2):219-32 ·
· Calvo AM, Bok J, Brooks W, Keller NP (2004) veA is required for toxin and sclerotial production in Aspergillus parasiticus. Appl. Environ. Microbiol. 70(8):4733-9 (PMC492383) ·
· Wilson RA, Chang PK, Dobrzyn A, Ntambi JM, Zarnowski R, Keller NP (2004) Two Delta9-stearic acid desaturases are required for Aspergillus nidulans growth and development. Fungal Genet. Biol. 41(5):501-9 ·
· Bok JW, Keller NP (2004) LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryotic Cell 3(2):527-35 (PMC387652) ·
· Zhang YQ, Keller NP (2004) Blockage of methylcitrate cycle inhibits polyketide production in Aspergillus nidulans. Mol. Microbiol. 52(2):541-50 ·
· Tsitsigiannis DI, Zarnowski R, Keller NP (2004) The lipid body protein, PpoA, coordinates sexual and asexual sporulation in Aspergillus nidulans. J. Biol. Chem. 279(12):11344-53 ·
· Shimizu K, Hicks JK, Huang TP, Keller NP (2003) Pka, Ras and RGS protein interactions regulate activity of AflR, a Zn(II)2Cys6 transcription factor in Aspergillus nidulans. Genetics 165(3):1095-104 (PMC1462812) ·
· Jin Y, Bok JW, Guzman-de-Peña D, Keller NP (2002) Requirement of spermidine for developmental transitions in Aspergillus nidulans. Mol. Microbiol. 46(3):801-12 ·
· Calvo AM, Wilson RA, Bok JW, Keller NP (2002) Relationship between secondary metabolism and fungal development. Microbiol. Mol. Biol. Rev. 66(3):447-59, table of contents (PMC120793) ·
· Wilson RA, Gardner HW, Keller NP (2001) Cultivar-dependent expression of a maize lipoxygenase responsive to seed infesting fungi. Mol. Plant Microbe Interact. 14(8):980-7 ·
· Calvo AM, Gardner HW, Keller NP (2001) Genetic connection between fatty acid metabolism and sporulation in Aspergillus nidulans. J. Biol. Chem. 276(28):25766-74 ·
· Shimizu K, Keller NP (2001) Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans. Genetics 157(2):591-600 (PMC1461531) ·
· Hodges RL, Kelkar HS, Xuei X, Skatrud PL, Keller NP, Adams TH, Kaiser RE, Vinci VA, McGilvray D (2000) Characterization of an echinocandin B-producing strain blocked for sterigmatocystin biosynthesis reveals a translocation in the stcW gene of the aflatoxin biosynthetic pathway. J. Ind. Microbiol. Biotechnol. 25(6):333-341 ·
· Burow GB, Gardner HW, Keller NP (2000) A peanut seed lipoxygenase responsive to Aspergillus colonization. Plant Mol. Biol. 42(5):689-701 ·
· Keller NP, Watanabe CM, Kelkar HS, Adams TH, Townsend CA (2000) Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulans. Appl. Environ. Microbiol. 66(1):359-62 (PMC91830) ·
· Butchko RA, Adams TH, Keller NP (1999) Aspergillus nidulans mutants defective in stc gene cluster regulation. Genetics 153(2):715-20 (PMC1460771) ·
· Calvo AM, Hinze LL, Gardner HW, Keller NP (1999) Sporogenic effect of polyunsaturated fatty acids on development of Aspergillus spp. Appl. Environ. Microbiol. 65(8):3668-73 (PMC91549) ·
· Fernandes M, Keller NP, Adams TH (1998) Sequence-specific binding by Aspergillus nidulans AflR, a C6 zinc cluster protein regulating mycotoxin biosynthesis. Mol. Microbiol. 28(6):1355-65 ·
· Hicks JK, Yu JH, Keller NP, Adams TH (1997) Aspergillus sporulation and mycotoxin production both require inactivation of the FadA G alpha protein-dependent signaling pathway. EMBO J. 16(16):4916-23 (PMC1170127) ·
· Keller NP, Nesbitt C, Sarr B, Phillips TD, Burow GB (1997) pH Regulation of Sterigmatocystin and Aflatoxin Biosynthesis in Aspergillus spp. Phytopathology 87(6):643-8 ·
· Keller NP, Hohn TM (1997) Metabolic Pathway Gene Clusters in Filamentous Fungi Fungal Genet. Biol. 21(1):17-29 ·
· Keller NP, Hohn TM (1997) Metabolic pathway gene clusters in filamentous fungi. Fungal Genet. Biol. 21(1):17-29 ·
· Kelkar HS, Skloss TW, Haw JF, Keller NP, Adams TH (1997) Aspergillus nidulans stcL encodes a putative cytochrome P-450 monooxygenase required for bisfuran desaturation during aflatoxin/sterigmatocystin biosynthesis. J. Biol. Chem. 272(3):1589-94 ·
· Brown DW, Adams TH, Keller NP (1996) Aspergillus has distinct fatty acid synthases for primary and secondary metabolism. Proc. Natl. Acad. Sci. U.S.A. 93(25):14873-7 (PMC26229) ·
· Kelkar HS, Keller NP, Adams TH (1996) Aspergillus nidulans stcP encodes an O-methyltransferase that is required for sterigmatocystin biosynthesis. Appl. Environ. Microbiol. 62(11):4296-8 (PMC168255) ·
· Yu JH, Butchko RA, Fernandes M, Keller NP, Leonard TJ, Adams TH (1996) Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus. Curr. Genet. 29(6):549-55 ·
· Brown DW, Yu JH, Kelkar HS, Fernandes M, Nesbitt TC, Keller NP, Adams TH, Leonard TJ (1996) Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans. Proc. Natl. Acad. Sci. U.S.A. 93(4):1418-22 (PMC39953) ·
· Keller NP, Segner S, Bhatnagar D, Adams TH (1995) stcS, a putative P-450 monooxygenase, is required for the conversion of versicolorin A to sterigmatocystin in Aspergillus nidulans. Appl. Environ. Microbiol. 61(10):3628-32 (PMC167660) ·
· Keller NP, Adams TH (1995) Analysis of a mycotoxin gene cluster in Aspergillus nidulans. SAAS Bull. Biochem. Biotechnol. 8:14-21 ·
· Keller NP, Kantz NJ, Adams TH (1994) Aspergillus nidulans verA is required for production of the mycotoxin sterigmatocystin. Appl. Environ. Microbiol. 60(5):1444-50 (PMC201501) ·
· Yu J, Cary JW, Bhatnagar D, Cleveland TE, Keller NP, Chu FS (1993) Cloning and characterization of a cDNA from Aspergillus parasiticus encoding an O-methyltransferase involved in aflatoxin biosynthesis. Appl. Environ. Microbiol. 59(11):3564-71 (PMC182499) ·
· Keller NP, Dischinger HC, Bhatnagar D, Cleveland TE, Ullah AH (1993) Purification of a 40-kilodalton methyltransferase active in the aflatoxin biosynthetic pathway. Appl. Environ. Microbiol. 59(2):479-84 (PMC202130) ·
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