Publications

                For the complete list of publications, Check the following links

List of Publications: (in reverse chronological order) 

11. Selective targeting of chemically modified miR-34a to prostate cancer using a small molecule ligand and an endosomal escape agent. A.   M. Abdelaal, I. S. Sohal, S. Iyer, K. Sudarshan, E. A. Orellana, K. E.  Ozcan, A. P. Santos, P. S. Low, A. L. Kasinski, Mol. Ther. Nucleic Acids, 2024, 102193. DOI: 10.1016/j.otmn.2024.102193

10. Developing folate-conjugated miR-34a therapeutic for prostate cancer treatment: Challenges and  promises. W. Li, Y. Wang, X. Liu, S. Wu, M. Wang, S. G. Turowski,  J. A. Spernyak,  A. Tracz, A. M. Abdelaal, K. Sudarshan, I. Puzanov, G. Chatta, A. L. Kasinski, D. G. Tang, Int. J. Mol. Sci.  , 2024, DOI: 10.3390/ijms25042123 

9. A first-in-class fully modified version of miR-34a with outstanding stability, activity, antitumor efficacy. A. M. Abdelaal, I. S. Sohal, S. Iyer, K. Sudarshan, H. Kothandaraman, N. A. Lanman, P. S. Low, A. L. Kasinski, Oncogene, 2023, 42, 2985-2999. DOI: 10.1038/s41388023-02801-8

8. Development of a simple high-throughput assay for directed evolution of enantioselective sulfoxide reductases. V. Tarallo, K. Sudarshan, V. Nosek, J. Misek, Chem. Commun. 2020, 56, 5386-5388. DOI: 10.1039/d0cc01660h

7. Regulation of mRNA translation by a photo riboswitch, K. A. Rotstan, M. M. Abdelsayed, L. F. Passalacqua, F. Chizzolini, K. Sudarshan, A. R. Chamberlin, J. Misek, A. Luptak, Elife, 2020, 9, e51737. DOI:10.7554/elife.51737

6. Discovery of a Isocoumarin analogue that modulates neuronal functions via neurotrophin receptor TrkB, K. Sudarshan, B. Arun Kumar, D. Shalini, B. Ishani, Y. Prem, I. S. Aidhen, Bioorg. Med. Chem. Lett. 2019, 29, 585-590. DOI: 10.1016/j.bmcl.2018.12.057

5. Synthesis of unsymmetrical linear diarylheptanoids and their enantiomers and anti proliferative activity studies, K. Sudarshan, G. Perumal, I. S. Aidhen, M. Doble Eur. J. Org. Chem. 2018, 6379-6387. DOI:10.1002/ejoc.201801211

4. Convenient synthesis of 3-glycosylated isocoumarins, K. Sudarshan, I. S. Aidhen, Eur. J. Org. Chem. 2017, 34-38. DOI: 10.1002/ejoc.201601264

3. Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins, M. Ramanan, S. Sinha, K. Sudarshan, I. S. Aidhen and M. Doble, Eur. J. Med. Chem. 2016, 124, 428-434. DOI: 10.1016/j.ejmech.2016.08.066

2. Synthesis of 3-aryl isocoumarins by using acyl anion chemistry and synthesis of thunberginol A and cajanolactone A, K. Sudarshan, M. K. Manna, I. S. Aidhen, Eur. J. Org. Chem. 2015, 1797-1803. DOI: 10.1002/ejoc.201403524

1. Synthesis of (+)-centrolobine and its analogues using acyl anion chemistry, K. Sudarshan, I. S. Aidhen, Eur. J. Org. Chem. 2013, 2298-2302. DOI: 10.1002/ejoc.201300097