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As a translational biomedical laboratory, the Kasinski Lab is committed to both basic discovery and clinical application. As such, the goal of the Kasinski laboratory is to gain a better understanding of epigenetic processes in cancer, including the role of non-coding RNAs (ncRNAs) and to apply this knowledge to the development of RNA-based therapeutics. The Kasinski lab is actively working on the following projects:
As a translational biomedical laboratory, the Kasinski Lab is committed to both basic discovery and clinical application. As such, the goal of the Kasinski laboratory is to gain a better understanding of epigenetic processes in cancer, including the role of non-coding RNAs (ncRNAs) and to apply this knowledge to the development of RNA-based therapeutics. The Kasinski lab is actively working on the following projects:
Main Research Projects
Tackling the holy grail of small RNA delivery, overcoming many of the challenges associated with achieving tumor-cell-specific delivery in the absence of unwanted toxicity. Increasing miRNAs stability to improve RNA-based therapeutics, using full chemical modification, which leads to reduced dosing, ultimately reducing cost and increasing patient compliance.
Identifying the mechanisms and biogenesis of extracellular vesicles (EVs), including mechanisms involved in loading of RNAs into EVs.
Identifying miRNAs and protein-coding genes that influence chemotherapeutic sensitivity and resistance, with an emphasis on epigenetic factors and determining their mechanism.
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