NEWS AND PRESS RELEASES
NEWS AND PRESS RELEASES
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PUBLICATIONS
PUBLICATIONS
2024
2024
Kelley AM, Del Valle EJ, Zaman S, Karkhanis AN. (2024). Adolescent ethanol exposure promotes mechanical allodynia and alters dopamine transmission in the nucleus accumbens shell. Pain, 165(6):e55-e64. PMID: 37962155.
Serafini RA, Farzinpour Z, Patel V, Kelley AM, Estill M, Pryce KD, Sakloth F, Teague CD, Torres-Berrio A, Nestler EJ, Shen L, Akbarian S, Karkhanis AN, Blitzer RD, Zachariou V. (2024). Nucleus accumbens myocyte enhancer factor 2C mediates the maintainence of peripheral nerve injury-induced physiological and behavioral maladaptations. Pain, doi: 10.1097/j.pain.0000000000003316. Online ahead of print. PMID: 38985454.
Estave PM, Albertson SE, Karkhanis AN, Jones SR. (2024). Co-targeting the kappa opioid receptor and dopamine transporter reduces motivation to self-administer cocaine and partially reverses dopamine system dysregulation. Science Reports, 14(1):6509. PMID: 38499566.
Pirino BE, Hawks A, Carpenter BA, Candelas PG, Gargiulo AT, Curtis GR, Karkhanis AN, Barson JR. (2024). Kappa-opioid receptor stimulation in the nucleus accumbens shell and ethanol drinking: Differential effects by rostro-caudal location and level of drinking. Neuropsychopharmacology, 49(10):1550-1558. PMID: 38528134.
2023
2023
Karkhanis AN, West AM, Jones SR. (2023). Kappa opioid receptor agonist U50,488 inhibits dopamine more in caudal than rostral nucleus accumbens core. Basic & Clinical Pharmacology & Toxicology, 133(5):526-534. PMID: 37539456.
Pirino BE, Kelley AM, Karkhanis AN, Barson JR. (2023). A critical review of effects on ethanol intake of the dynorphin/kappa opioid receptor system in the extended amygdala: From inhibition to stimulation. Alcohol, Clinical and Experimental Research, 47(6):1027-1038. PMID: 37042026.
2022
2022
Estave PM, Spodnick MB, Karkhanis AN. (2022). KOR Control over Addiction Processing: An Exploration of the Mesolimbic Dopamine Pathway. Handbook Experimental Pharmacology, 271:351-377. PMID: 33301050
Pirino BE, Martin CR, Carpenter BA, Curtis GR, Curran-Alfaro CM, Samels SB, Barker JM, Karkhanis AN, Barson JR. (2022). Sex-related differences in pattern of ethanol drinking under the intermittent-access model and its impact on exploratory and anxiety-like behavior in Long-Evans rats. Alcohol, Clinical and Experimental Research, 46(7):1282-1293. PMID: 35491472
2021
2021
Leon Z, Shah K, Bailey LS, Karkhanis AN, Sirohi S. (2021). Patterned feeding of hyper-palatable food (oreo cookies) reduces alcohol drinking in rats. Frontiers in Behavioral Neuroscience, 15:725856. PMID: 34744651
2020
2020
Spodnick MB, Amirault RT, Towner TT, Varlinskaya EI, Spear LP, Karkhanis AN. (2020). Adolescent intermittent ethanol exposure effects on kappa opioid receptor mediated dopamine transmission: Sex and age of exposure matter. Brain Sciences, 10(8):472. PMID: 32717830
Pirino BE, Spodnick MB, Gargiulo AT, Curtis GR, Barson JR, Karkhanis AN. (2020). Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis. Neuropharmacology, 181:108341. PMID: 33011200
Karkhanis AN, Al-Hasani R. (2020). Dynorphin and its role in alcohol use disorder. Brain Research 1735:146742. PMID: 32114059
2019
2019
Margolis EB, Karkhanis AN. (2019). Dopaminergic cellular and circuit contributions to kappa opioid receptor mediated aversion. Neurochemistry International, doi: 10.1016/j.neuint.2019. PMID: 31301327
Karkhanis AN, Leach AC, Yorgason JT, Uneri A, Barth S, Niere F, Alexander NJ, Weiner JL, McCool BA, Raab-Graham KF, Ferris MJ, Jones SR. (2019). Chronic social isolation stress during peri-adolescence alters presynaptic dopamine terminal dynamics via augmentation in accumbal dopamine availability. ACS Chemical Neuroscience, 10(4):2033-2044. PMID: 30284806
2018
2018
Siciliano CA, Karkhanis AN, Holleran KM, Melchior JR, Jones SR. (2018). Cross-Species Alterations in Synaptic Dopamine Regulation After Chronic Alcohol Exposure. Handbook Experimental Pharmacology, doi: 10.1007/164_2018_106. PMID: 29675581
2017
2017
Karkhanis AN, Holleran KM, Jones SR. (2017). Dynorphin/Kappa Opioid Receptor Signaling in Preclinical Models of Alcohol, Drug, and Food Addiction. International Review of Neurobiology, 136:53-88. PMID: 29056156
2016
2016
Karkhanis AN, Rose JH, Weiner JL, Jones SR. (2016). Early-Life Social Isolation Stress Increases Kappa Opioid Receptor Responsiveness and Downregulates the Dopamine System. Neuropsychopharmacology, 41(9):2263-74. PMID: 26860203
Karkhanis AN, Huggins KN, Rose JH, Jones SR. (2016). Switch from excitatory to inhibitory actions of ethanol on dopamine levels after chronic exposure: Role of kappa opioid receptors. Neuropharmacology, 110(Pt A):190-197. PMID: 27450094
Karkhanis AN, Beveridge TJ, Blough BE, Jones SR, Ferris MJ. (2016). The individual and combined effects of phenmetrazine and mgluR2/3 agonist LY379268 on the motivation to self-administer cocaine. Drug and Alcohol Dependence, 166:51-60. PMID: 27394931
Rose JH, Karkhanis AN, Steiniger-Brach B, Jones SR. (2016). Distinct Effects of Nalmefene on Dopamine Uptake Rates and Kappa Opioid Receptor Activity in the Nucleus Accumbens Following Chronic Intermittent Ethanol Exposure. International Journal of Molecular Science, 17(8). PMID: 27472317
Rose JH, Karkhanis AN, Chen R, Gioia D, Lopez MF, Becker HC, McCool BA, Jones SR. (2016). Supersensitive Kappa Opioid Receptors Promotes Ethanol Withdrawal-Related Behaviors and Reduce Dopamine Signaling in the Nucleus Accumbens. Int J Neuropsychopharmacology, 19(5). PMID: 26625893
Butler TR, Karkhanis AN, Jones SR, Weiner JL. (2016). Adolescent Social Isolation as a Model of Heightened Vulnerability to Comorbid Alcoholism and Anxiety Disorders. Alcoholism: Clinical Experimental Research, 40(6):1202-14. PMID: 27154240
Yorgason JT, Calipari ES, Ferris MJ, Karkhanis AN, Fordahl SC, Weiner JL, Jones SR. (2016). Social isolation rearing increases dopamine uptake and psychostimulant potency in the striatum. Neuropharmacology, 101:471-9. PMID: 26525189
2015
2015
Karkhanis AN, Rose JH, Huggins KN, Konstantopoulos JK, Jones SR. (2015). Chronic intermittent ethanol exposure reduces presynaptic dopamine neurotransmission in the mouse nucleus accumbens. Drug and Alcohol Dependence, 150:24-30. PMID: 25765483
Karkhanis AN, Alexander NJ, McCool BA, Weiner JL, Jones SR. (2015). Chronic social isolation during adolescence augments catecholamine response to acute ethanol in the basolateral amygdala. Synapse, 69(8):385-95. PMID: 25963724
2014
2014
Karkhanis AN, Locke JL, McCool BA, Weiner JL, Jones SR. (2014). Social isolation rearing increases nucleus accumbens dopamine and norepinephrine responses to acute ethanol in adulthood. Alcoholism: Clinical Experimental Research, 38(11):2770-9. PMID: 25421514
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