NEWS AND PRESS RELEASES

PUBLICATIONS

2020

  • Spodnick MB, Amirault RT, Towner TT, Varlinskaya EI, Spear LP, Karkhanis AN. (2020). Adolescent intermittent ethanol exposure effects on kappa opioid receptor mediated dopamine transmission: Sex and age of exposure matter. Brain Sciences, 10(8):472. PMID: 32717830

  • Pirino BE, Spodnick MB, Gargiulo AT, Curtis GR, Barson JR, Karkhanis AN. (2020). Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis. Neuropharmacology, 181:108341. PMID: 33011200

  • Estave PM, Spodnick MB, Karkhanis AN. (2020). KOR Control over Addiction Processing: An Exploration of the Mesolimbic Dopamine Pathway. Handbook Experimental Pharmacology, [Epub ahead of print]. PMID: 33301050

  • Karkhanis AN, Al-Hasani R. (2020). Dynorphin and its role in alcohol use disorder. Brain Research 1735:146742. PMID: 32114059

2019

  • Margolis EB, Karkhanis AN. (2019). Dopaminergic cellular and circuit contributions to kappa opioid receptor mediated aversion. Neurochemistry International, doi: 10.1016/j.neuint.2019. PMID: 31301327

  • Karkhanis AN, Leach AC, Yorgason JT, Uneri A, Barth S, Niere F, Alexander NJ, Weiner JL, McCool BA, Raab-Graham KF, Ferris MJ, Jones SR. (2019). Chronic social isolation stress during peri-adolescence alters presynaptic dopamine terminal dynamics via augmentation in accumbal dopamine availability. ACS Chemical Neuroscience, 10(4):2033-2044. PMID: 30284806

2018

  • Siciliano CA, Karkhanis AN, Holleran KM, Melchior JR, Jones SR. (2018). Cross-Species Alterations in Synaptic Dopamine Regulation After Chronic Alcohol Exposure. Handbook Experimental Pharmacology, doi: 10.1007/164_2018_106. PMID: 29675581

2017

  • Karkhanis AN, Holleran KM, Jones SR. (2017). Dynorphin/Kappa Opioid Receptor Signaling in Preclinical Models of Alcohol, Drug, and Food Addiction. International Review of Neurobiology, 136:53-88. PMID: 29056156

2016

  • Karkhanis AN, Rose JH, Weiner JL, Jones SR. (2016). Early-Life Social Isolation Stress Increases Kappa Opioid Receptor Responsiveness and Downregulates the Dopamine System. Neuropsychopharmacology, 41(9):2263-74. PMID: 26860203

  • Karkhanis AN, Huggins KN, Rose JH, Jones SR. (2016). Switch from excitatory to inhibitory actions of ethanol on dopamine levels after chronic exposure: Role of kappa opioid receptors. Neuropharmacology, 110(Pt A):190-197. PMID: 27450094

  • Karkhanis AN, Beveridge TJ, Blough BE, Jones SR, Ferris MJ. (2016). The individual and combined effects of phenmetrazine and mgluR2/3 agonist LY379268 on the motivation to self-administer cocaine. Drug and Alcohol Dependence, 166:51-60. PMID: 27394931

  • Rose JH, Karkhanis AN, Steiniger-Brach B, Jones SR. (2016). Distinct Effects of Nalmefene on Dopamine Uptake Rates and Kappa Opioid Receptor Activity in the Nucleus Accumbens Following Chronic Intermittent Ethanol Exposure. International Journal of Molecular Science, 17(8). PMID: 27472317

  • Rose JH, Karkhanis AN, Chen R, Gioia D, Lopez MF, Becker HC, McCool BA, Jones SR. (2016). Supersensitive Kappa Opioid Receptors Promotes Ethanol Withdrawal-Related Behaviors and Reduce Dopamine Signaling in the Nucleus Accumbens. Int J Neuropsychopharmacology, 19(5). PMID: 26625893

  • Butler TR, Karkhanis AN, Jones SR, Weiner JL. (2016). Adolescent Social Isolation as a Model of Heightened Vulnerability to Comorbid Alcoholism and Anxiety Disorders. Alcoholism: Clinical Experimental Research, 40(6):1202-14. PMID: 27154240

  • Yorgason JT, Calipari ES, Ferris MJ, Karkhanis AN, Fordahl SC, Weiner JL, Jones SR. (2016). Social isolation rearing increases dopamine uptake and psychostimulant potency in the striatum. Neuropharmacology, 101:471-9. PMID: 26525189

2015

  • Karkhanis AN, Rose JH, Huggins KN, Konstantopoulos JK, Jones SR. (2015). Chronic intermittent ethanol exposure reduces presynaptic dopamine neurotransmission in the mouse nucleus accumbens. Drug and Alcohol Dependence, 150:24-30. PMID: 25765483

  • Karkhanis AN, Alexander NJ, McCool BA, Weiner JL, Jones SR. (2015). Chronic social isolation during adolescence augments catecholamine response to acute ethanol in the basolateral amygdala. Synapse, 69(8):385-95. PMID: 25963724

2014

  • Karkhanis AN, Locke JL, McCool BA, Weiner JL, Jones SR. (2014). Social isolation rearing increases nucleus accumbens dopamine and norepinephrine responses to acute ethanol in adulthood. Alcoholism: Clinical Experimental Research, 38(11):2770-9. PMID: 25421514