A Tumor-Specific Molecular Network Promotes Tumor Growth in Drosophila by Enforcing a Jun N-Terminal Kinase-Yorkie Feedforward Loop. Waghmare I, Gangwani K, Rai A, Singh A, Kango-Singh M. Cancers (Basel). 2024 May 2;16(9):1768. doi: 10.3390/cancers16091768. PMID: 38730720
Genetic mechanism regulating diversity in the placement of eyes on the head of animals. Puli OR, Gogia N, Chimata AV, Yorimitsu T, Nakagoshi H, Kango-Singh M, Singh A. Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2316244121. doi: 10.1073/pnas.2316244121. Epub 2024 Apr 8. PMID: 38588419
miR-277 targets the proapoptotic gene-hid to ameliorate Aβ42-mediated neurodegeneration in Alzheimer's model. Deshpande P, Chen CY, Chimata AV, Li JC, Sarkar A, Yeates C, Chen CH, Kango-Singh M, Singh A. Cell Death Dis. 2024 Jan 18;15(1):71. doi: 10.1038/s41419-023-06361-3.PMID: 38238337
A Tumour-Specific Molecular Network Promotes Tumour Growth in Drosophila by Enforcing a JNK-YKI Feedforward Loop. Waghmare I, Gangwani K, Rai A, Singh A, Kango-Singh M. bioRxiv [Preprint]. 2023 Oct 18:2023.10.18.561369. doi: 10.1101/2023.10.18.561369. Update in: Cancers (Basel). 2024 May 02;16(9):1768. doi: 10.3390/cancers16091768.
PMID: 37904920
Transcriptional pausing factor M1BP regulates cellular homeostasis by suppressing autophagy and apoptosis in Drosophila eye. Chimata AV, Darnell H, Raj A, Kango-Singh M, Singh A. Autophagy Rep. 2023;2(1):2252307. doi: 10.1080/27694127.2023.2252307. Epub 2023 Sep 5. PMID: 37746026
N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye. Deshpande P, Chimata AV, Snider E, Singh A, Kango-Singh M, Singh A. Cell Death Dis. 2023 Jul 28;14(7):478. doi: 10.1038/s41419-023-05973-z. PMID: 37507384
Yorkie-Cactus (IκBα)-JNK axis promotes tumor growth and progression in Drosophila. Snigdha K, Singh A, Kango-Singh M. Oncogene. 2021 Jun;40(24):4124-4136. doi: 10.1038/s41388-021-01831-4. Epub 2021 May 20. PMID: 34017079
A Two-Clone Approach to Study Signaling Interactions among Neuronal Cells in a Pre-clinical Alzheimer's Disease Model. Yeates CJ, Sarkar A, Deshpande P, Kango-Singh M, Singh A. iScience. 2020 Nov 18;23(12):101823. doi: 10.1016/j.isci.2020.101823. eCollection 2020 Dec 18. PMID: 33319169
Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo. Gogia N, Sarkar A, Mehta AS, Ramesh N, Deshpande P, Kango-Singh M, Pandey UB, Singh A. Neurobiol Dis. 2020 Jul;140:104837. doi: 10.1016/j.nbd.2020.104837. Epub 2020 Mar 19. PMID: 32199908
Tep1 Regulates Yki Activity in Neural Stem Cells in Drosophila Glioma Model. Gangwani K, Snigdha K, Kango-Singh M. Front Cell Dev Biol. 2020 May 8;8:306. doi: 10.3389/fcell.2020.00306. eCollection 2020. PMID: 32457905
A Positive Feedback Loop of Hippo- and c-Jun-Amino-Terminal Kinase Signaling Pathways Regulates Amyloid-Beta-Mediated Neurodegeneration. Irwin M, Tare M, Singh A, Puli OR, Gogia N, Riccetti M, Deshpande P, Kango-Singh M, Singh A. Front Cell Dev Biol. 2020 Mar 13;8:117. doi: 10.3389/fcell.2020.00117. eCollection 2020. PMID: 32232042
Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation Minata M, Audia A, Shi J, Lu S, Bernstock J, Pavlyukov MS, Das A, Kim SH, Shin YJ, Lee Y, Koo H, Snigdha K, Waghmare I, Guo X, Mohyeldin A, Gallego-Perez D, Wang J, Chen D, Cheng P, Mukheef F, Contreras M, Reyes JF, Vaillant B, Sulman EP, Cheng SY, Markert JM, Tannous BA, Lu X, Kango-Singh M, Lee LJ, Nam DH, Nakano I, Bhat KP. Cell Rep. 2019 Feb 12;26(7):1893-1905.e7. doi: 10.1016/j.celrep.2019.01.076. PMID: 30759398
A soy protein Lunasin can ameliorate amyloid-beta 42 mediated neurodegeneration in Drosophila eye. Sarkar A, Gogia N, Glenn N, Singh A, Jones G, Powers N, Srivastava A, Kango-Singh M, Singh A. Sci Rep. 2018 Sep 10;8(1):13545. doi: 10.1038/s41598-018-31787-7. PMID: 30202077
Water‐Soluble Zinc Porphyrin Capable of Light‐Induced Photocleavage of DNA: Cell Localization Studies in Drosophila Melanogaster and Light Activated Treatment of Lung Cancer Cells Yoho J, Wogensthal K, Bennett TL Palmer J, Comfort KK, Kango-Singh M, Swavey S, Stuart CH, Gmeiner WH.. Eur J Inorg Chem. 2017;2017(1):153-159.
Cullin-4 regulates Wingless and JNK signaling-mediated cell death in the Drosophila eye. Tare M, Sarkar A, Bedi S, Kango-Singh M, Singh A. Cell Death Dis. 2016 Dec 29;7(12):e2566. doi: 10.1038/cddis.2016.338. PMID: 28032862
FOXD1-ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells. Cheng P, Wang J, Waghmare I, Sartini S, Coviello V, Zhang Z, Kim SH, Mohyeldin A, Pavlyukov MS, Minata M, Valentim CL, Chhipa RR, Bhat KP, Dasgupta B, La Motta C, Kango-Singh M, Nakano I. Cancer Res. 2016 Dec 15;76(24):7219-7230. Epub 2016 Aug 28. PMID: 27569208
Loss of Cell Adhesion Increases Tumorigenic Potential of Polarity Deficient Scribble Mutant Cells. Waghmare I, Kango-Singh M. PLoS One. 2016 Jun 21;11(6):e0158081. doi: 10.1371/journal.pone.0158081. eCollection 2016. PMID: 27327956
The Hippo pathway effector Yki downregulates Wg signaling to promote retinal differentiation in the Drosophila eye. Wittkorn E, Sarkar A, Garcia K, Kango-Singh M, Singh A. Development. 2015 Jun 1;142(11):2002-13. doi: 10.1242/dev.117358. Epub 2015 May 14. PMID: 25977365
Drosophila C-terminal Src kinase regulates growth via the Hippo signaling pathway. Kwon HJ, Waghmare I, Verghese S, Singh A, Singh A, Kango-Singh M. Dev Biol. 2015 Jan 1;397(1):67-76. doi: 10.1016/j.ydbio.2014.10.010. Epub 2014 Oct 22. PMID: 25446534
Toxicity and localization studies of a potential photodynamic therapy agent in Drosophila. Yoho J, Stroh C, Swavey S, Kango-Singh M. Genesis. 2014 Apr;52(4):309-14. doi: 10.1002/dvg.22760. Epub 2014 Mar 12. PMID: 24616213
Homeotic Gene teashirt (tsh) has a neuroprotective function in amyloid-beta 42 mediated neurodegeneration. Moran MT, Tare M, Kango-Singh M, Singh A. PLoS One. 2013 Nov 25;8(11):e80829. doi: 10.1371/journal.pone.0080829. eCollection 2013. PMID: 24282556
Novel neuroprotective function of apical-basal polarity gene crumbs in amyloid beta 42 (aβ42) mediated neurodegeneration. Steffensmeier AM, Tare M, Puli OR, Modi R, Nainaparampil J, Kango-Singh M, Singh A. PLoS One. 2013 Nov 18;8(11):e78717. doi: 10.1371/journal.pone.0078717. eCollection 2013. PMID: 24260128
Scribble acts in the Drosophila fat-hippo pathway to regulate warts activity. Verghese S, Waghmare I, Kwon H, Hanes K, Kango-Singh M. PLoS One. 2012;7(11):e47173. doi: 10.1371/journal.pone.0047173. Epub 2012 Nov 5. PMID: 23144804
Domain specific genetic mosaic system in the Drosophila eye.Tare M, Puli OR, Moran MT, Kango-Singh M, Singh A. Genesis. 2013 Jan;51(1):68-74. doi: 10.1002/dvg.22355. Epub 2012 Nov 26. PMID: 23109378
Hippo signalling controls Dronc activity to regulate organ size in Drosophila. Verghese S, Bedi S, Kango-Singh M. Cell Death Differ. 2012 Oct;19(10):1664-76. doi: 10.1038/cdd.2012.48. Epub 2012 May 4. PMID: 22555454
Tumor suppression by cell competition through regulation of the Hippo pathway. Chen CL, Schroeder MC, Kango-Singh M, Tao C, Halder G. Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):484-9. doi: 10.1073/pnas.1113882109. Epub 2011 Dec 21. PMID: 22190496
Activation of JNK signaling mediates amyloid-ß-dependent cell death. Tare M, Modi RM, Nainaparampil JJ, Puli OR, Bedi S, Fernandez-Funez P, Kango-Singh M, Singh A. PLoS One. 2011;6(9):e24361. doi: 10.1371/journal.pone.0024361. Epub 2011 Sep 14. PMID: 21949710
Opposing interactions between homothorax and Lobe define the ventral eye margin of Drosophila eye. Singh A, Tare M, Kango-Singh M, Son WS, Cho KO, Choi KW. Dev Biol. 2011 Nov 15;359(2):199-208. doi: 10.1016/j.ydbio.2011.08.017. Epub 2011 Sep 2. PMID: 21920354
Dorsal eye selector pannier (pnr) suppresses the eye fate to define dorsal margin of the Drosophila eye.Oros SM, Tare M, Kango-Singh M, Singh A. Dev Biol. 2010 Oct 15;346(2):258-71. doi: 10.1016/j.ydbio.2010.07.030. Epub 2010 Aug 5. PMID: 20691679
Larval legs of mulberry silkworm Bombyx mori are prototypes for the adult legs. Singh A, Kango-Singh M, Parthasarathy R, Gopinathan KP. Genesis. 2007 Apr;45(4):169-76. PMID: 17417803
The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Willecke M, Hamaratoglu F, Kango-Singh M, Udan R, Chen CL, Tao C, Zhang X, Halder G. Curr Biol. 2006 Nov 7;16(21):2090-100. Epub 2006 Sep 21. PMID: 16996265
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H, Halder G. Nat Cell Biol. 2006 Jan;8(1):27-36. Epub 2005 Dec 11. Erratum in: Nat Cell Biol. 2006 Jan;8(1):100. PMID: 16341207
Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Eder AM, Sui X, Rosen DG, Nolden LK, Cheng KW, Lahad JP, Kango-Singh M, Lu KH, Warneke CL, Atkinson EN, Bedrosian I, Keyomarsi K, Kuo WL, Gray JW, Yin JC, Liu J, Halder G, Mills GB. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12519-24. Epub 2005 Aug 22. PMID: 16116079
Dorso-ventral asymmetric functions of teashirt in Drosophila eye development depend on spatial cues provided by early DV patterning genes. Singh A, Kango-Singh M, Choi KW, Sun YH. Mech Dev. 2004 Apr;121(4):365-70. PMID: 15110046
Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Udan RS, Kango-Singh M*, Nolo R, Tao C, Halder G. Nat Cell Biol. 2003 Oct;5(10):914-20. Epub 2003 Sep 21. PMID: 14502294 * Equal first author
Eyeless collaborates with Hedgehog and Decapentaplegic signaling in Drosophila eye induction. Kango-Singh M, Singh A, Henry Sun Y. Dev Biol. 2003 Apr 1;256(1):49-60. PMID: 12654291
Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Kango-Singh M, Nolo R, Tao C, Verstreken P, Hiesinger PR, Bellen HJ, Halder G. Development. 2002 Dec;129(24):5719-30. PMID: 12421711
Eye suppression, a novel function of teashirt, requires Wingless signaling. Singh A, Kango-Singh M, Sun YH. Development. 2002 Sep;129(18):4271-80. PMID: 12183379
The wings of Bombyx mori develop from larval discs exhibiting an early differentiated state: a preliminary report. Kango-Singh M, Singh A, Gopinathan KP. J Biosci. 2001 Jun;26(2):167-77. PMID: 11426053
Neoplastic transformation and aberrant cell-cell interactions in genetic mosaics of lethal(2)giant larvae (lgl), a tumor suppressor gene of Drosophila. Agrawal N, Kango M, Mishra A, Sinha P. Dev Biol. 1995 Nov;172(1):218-29. PMID: 7589802
Epithelial hyperplasia of imaginal discs induced by mutations in Drosophila tumor suppressor genes: growth and pattern formation in genetic mosaics. Agrawal N, Joshi S, Kango M, Saha D, Mishra A, Sinha P. Dev Biol. 1995 Jun;169(2):387-98. PMID: 7781886
An improved method for chemical devitellinization of X-gal stained Drosophila embryos. Singh A, Kango M, Sinha P. Indian J Exp Biol. 1995 Feb;33(2):150-2. PMID: 7538973