RESEARCH

Research

Academic and Research Advisor: Prof. Dr. MinJun Kim

• Heterogenous Multilayer Solid-State Nanopore Fabrication and Single Molecule Analysis. Developed a novel chemically tuned dielectric breakdown (CT-CDB) method to fabricate heterogeneous multilayer nanopores composed of SiNx integrated with 2D materials (graphene, MoS₂, hBN) for single-molecule biosensing. Conducted protein translocation experiments demonstrating enhanced sensing capabilities and applied machine learning algorithms achieving over 96% accuracy for real-time structural classification. Work submitted to Nature Communications, highlighting interdisciplinary expertise spanning nanofabrication, materials science, biophysics, and artificial intelligence.

• Nanopore-Based Dual-Mode Analysis of DNA-Templated Silver Nanoclusters. Designed and fabricated solid-state nanopores to study the translocation behavior of DNA/AgNCs in various electrolytes. Demonstrated voltage- and pH-dependent stability differences between KNO₃ and KCl environments using fluorescence correlation and current blockade analysis. Results established AgNCs as potential ionic-responsive nanosensors, enhancing metallo-DNA understanding and advancing solid-state nanopore biosensing platforms.

• DNA Origami–Integrated Hybrid Nanopores for Protein Detection. Engineered hybrid solid-state nanopores by integrating DNA origami nanostructures to improve analyte capture and signal resolution. Demonstrated significantly enhanced sensitivity for holo-human serum transferrin (holo-hSTf) protein detection. Highlighted the role of DNA–protein interactions beyond spatial confinement, paving the way for ultrasensitive biosensing tools for disease biomarkers.

• Solid-State Nanopore Detection of Ultra-Short KYCDE Peptides. Utilized SixNy nanopores to investigate translocation dynamics of ultra-short peptides. Systematically evaluated peptide–pore interaction as a function of nanopore diameter, voltage, and analyte concentration. Identified aggregation behavior and signal-masking challenges in peptide detection, offering insight into optimizing nanopore systems for single-molecule proteomics and peptide sequencing.

Projects

• Numerical Investigation of Onera M6 Forward and Backward Swept C-Wing Configuration at Supersonic and Subsonic Speed, Final Year Project (2021), Research and Simulation. Research study of aerodynamics for Forward and Backward Swept C-wing at supersonic speed, to minimize the drag and control sonic boom at ground level using ANSYS Fluent.

• Automatic Sugarcane Planter, Integrated Design Project (2020), Design & Prototype. A remote-controlled autonomous sugarcane planter which prepares the land, makes furrows, plant sugarcane, fertilizes and cover-up the sugarcane billets at the same time.

• Speed Reducer Gearbox for Conveying System (2019), Design Calculation. A Gearbox of conveyor system which step-downs the input speed of the motor and delivers into the conveyor belt.

• Tri-Wheel Gas Cylinder Trolley (2018), Prototype. A manual stair climbing tri-wheel trolley which requires comparatively less force to climb up for same loading.