Synthetic Organic Chemistry

Synthetic chemistry (from the Greek word synthesis = the process of putting together) is the science of constructing molecules from atoms and/or (usually) simpler molecules. The discipline may be subdivided, according to the molecules involved, into synthetic organic chemistry and synthetic inorganic chemistry. The term organic synthesis is often used- may be incorrectly in strict terms despite common usage and history to mean the same as synthetic organic chemistry. Even the phrase chemical synthesis is sometimes used to designate the science of synthetic chemistry, although strictly speaking chemical synthesis is the process by which a particular molecule is synthesized in the laboratory.

As a field, organic synthesis can be divided into two major areas with further subdivisions. The invention, discovery, and development of new synthetic reactions, reagents, and catalysts are grouped under the area of synthetic methodology, or methods-oriented synthesis, whereas the synthetic pursuit of a defined molecule, natural or designed, is classified under target-oriented synthesis (total synthesis is included in this category).

We are working in the area of development of new synthetic methodologies.

Our Contribution:

1. A Route to 2‐Alkenyl‐3‐(tert‐butyldiphenylsilyl)amines and Application to the Construction of a Tricyclic Ring System. European Journal of Organic Chemistry 2013 (19), 4163-4174.  https://doi.org/10.1002/ejoc.201300319 

2. IBX-TfOH mediated oxidation of alcohols to aldehydes and ketones under mild reaction conditions. Tetrahedron Letters 61 (15), 151749. https://doi.org/10.1016/j.tetlet.2020.151749  highlighted in Organic chemistry highlights Oxidation: The Sherman/Williams Synthesis of Baulamycin A (organic-chemistry.org) 

3. (±)-Camphor sulfonic acid assisted IBX-based oxidation of 1° and 2° alcohols. Tetrahedron Letters 81, 153298. https://doi.org/10.1016/j.tetlet.2021.153298