Publications

1. K. Tsuji, T. Tanigawa, Y. Tsutsumi, T. Kubo, N. Kaji, An initial study of cell separation based on mechanical properties using a sponge-like monolithic polymer, Talanta Open, in press, DOI: 10.1016/j.talo.2024.100321

1. K. Iijima, N. Kaji, M. Tokeshi, Y. Baba, Micro- and nanochamber array system for single enzyme assays, Scientific Reports, 13, 13322 (2023) DOI: 10.1038/s41598-023-40544-4

2. Y. Kishimoto, S. Ide, T. Naito, Y. Nakashima, Y. Nakanishi, N. Kaji, Development of a microfluidic ion current measurement system for a single microplastic detection, Journal of Robotics and Mechatronics, 35, 1193 (2023) DOI: 10.20965/jrm.2023.p1193

3. Y. Banno, T. Nomiyama, S. Okuno, S. Ide, N. Kaji, Quantitative Evaluation of Interleukin-4 by Immunowall Devices Made of Gelatin Methacryloyl Hydrogel, Molecules, 28, 4635 (2023) DOI: 10.3390/molecules28124635

4. Y. Onizuka, K. Fujita, S. Ide, T. Naito, N. Kaji, Antioxidants encapsulated milk-derived exosomes for functional food development, Analytical Sciences, 39, 705-712 (2023), DOI: 10.1007/s44211-023-00278-9  

Refereed Conference proceedings

1. T. Nomiyama, S. Ide, N. Kaji, Development of a microfluidic device for mesurement of deformability and pluripotency from the same cell, The proceedings of μTAS 2023, Katowice, Poland (2023)

2. . Y. Banno, T. Nomiyama, S. Okuno, N. Kaji, Gelma-hydrogel immunowall device for IL-6 quantitation in human serum, The proceedings of μTAS 2023, Katowice, Poland (2023)

3. . Y. Yamakawa, W. Iwasaki, N. Kaji, Fabrication of villi microintenstinal structures for evaluation of intestinal microbiota, The proceedings of μTAS 2023, Katowice, Poland (2023)

1. Y. M. Metias, M. M. Hosny, M. M. Ayad, N. Kaji, High‐throughput spectrofluorimetric approach for one-step, sensitive, and green assays of alfuzosin hydrochloride using a 96-well microplate reader: Application to tablet formulations and human urine, Talanta Open, 6, 100139 (2022) DOI: 10.1016/j.talo.2022.100139

2. H. Murahara, N. Kaji, M. Tokeshi, Y. Baba, Enzyme kinetics in confined geometries at a single enzyme level, Analyst, 147, 1375-1384 (2022) DOI: 10.1039/d1an02024b

1. T. Kasama, M. Sun, N. Kaji, S. i. Akiyama, Y. Yuzawa, M. Tokeshi, S. Matsuo, Y. Baba, Microchip immunoassays for monitoring renal function: Rapid, low-cost, and highly sensitive quantification of urinary biomarkers of diabetic nephropathy, Micromachines, 12, 1353 (2021) DOI: 10.3390/mi12111353   

2. M. Terada, S. Ide, T. Naito, N. Kimura, M. Matsusaki, N. Kaji, Label-free cancer stem-like cell assay conducted at a single cell level using microfluidic mechanotyping devices, Analytical Chemistry, 93, 14409-14416 (2021) DOI: 10.1021/acs.analchem.1c02316 - This paper was selected as a supplementary journal cover picture of Analytical Chemistry. 

3. T. Yasui, P. Paisrisarn, T. Yanagida, Y. Konakade, Y. Nakamura, K. Nagashima, M. Musa, I. A. Thiodorus, H. Takahashi, T. Naganawa, T. Shimada, N. Kaji, T. Ochiya, T. Kawai and Y. Baba, Molecular profiling of extracellular vesicles via charge-based capture using oxide nanowire microfluidics, Biosensors and Bioelectronics, 113589 (2021) DOI: 10.1016/j.bios.2021.113589

4. H. Takahashi, T. Yasui, H. Kashida, K. Makino, K. Shinjo, Q. Liu, T. Shimada, S. Rahong, N. Kaji, H. Asanuma, Y. Baba, Microheater-integrated zinc oxide nanowire microfluidic device for hybridization-based detection of target single-stranded DNA, Nanotechnology, 32, 255301 (2021) DOI: 10.1088/1361-6528/abef2c

5. S. Ryuzaki, T. Yasui, M. Tsutsui, K. Yokota, Y. Komoto, P. Paisrisarn, N. Kaji, D. Ito, K. Tamada, T. Ochiya, M. Taniguchi, Y. Baba, T. Kawai, Rapid discrimination of extracellular vesicles by shape distribution analysis, Analytical Chemistry, 93, 7037-7044 (2021) DOI: 10.1021/acs.analchem.1c00258 

6. A. M. Zeid, J. J. M. Nasr, F. Belal, M. Walash, N. Kaji, Y. Baba, Microfluidic fast chiral separation of baclofen and phenylalanine enantiomers based on cyclodextrin-electrokinetic chromatography, Microchemical Journal, 160, 105770 (2021) DOI:10.1016/j.microc.2020.105770

7. A. M. Zeid, J. J. M. Nasr, F. Belal, M. I. Walash, Y. Baba, N. Kaji, Determination of three antiepileptic drugs in pharmaceutical formulations using microfluidic chips coupled with light-emitting diode induced fluorescence detection, Spectrochimica Acta. Part A: Molecular and Biomolecular Spectroscopy, 246, 119021 (2021) DOI:10.1016/j.saa.2020.119021 

Refereed Conference proceedings

Articles

1. 加地範匡、細胞核・細胞質内分子夾雑系定量評価法の開発、8, 9, 2021 Sep., CMCB NEWS LETTER

2. 寺田美悠, 井手幸子, 内藤豊裕, 松崎典弥, 加地範匡, 単一細胞変形能測定によるヒト結腸腺がん細胞の多能性評価, 化学とマイクロ・ナノシステム, 20, 29-30 (2021) ISSN:1881-364X

3. 加地範匡、ナノピラー、先端の分析法　新訂第2版、株式会社エヌ・ティー・エス、506-510. ISBN: 978-4-86043-737-4

4. 木村笑、内藤豊裕、加地範匡、配列分析、先端の分析法　新訂第2版、株式会社エヌ・ティー・エス、802-807. ISBN: 978-4-86043-737-4

5. 内藤豊裕、木村笑、加地範匡、第3章　マイクロ流体デバイスによる単一がん細胞診断、188-194, 2021, in AI・ナノ・量子による超高感度・迅速バイオセンシング ―超早期パンデミック検査・超早期診断・POCTから健康長寿社会へ―（馬場嘉信、柳田剛、加地範匡　監修）、シーエムシー出版

Books

1. 馬場嘉信、柳田剛、加地範匡　監修、AI・ナノ・量子による超高感度・迅速バイオセンシング ―超早期パンデミック検査・超早期診断・POCTから健康長寿社会へ―、シーエムシー出版、2021

1. T. Shimada, T. Yasui, A. Yonese, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai, Y. Baba, Mechanical rupture-based antibacterial and cell-compatible ZnO/SiO2 nanowire structures formed by bottom-up approaches, Micromachines, 11, 610 (2020)  DOI:10.3390/mi11060610

2. H. Suzuki, K. Fujiyoshi, N. Kaji, M. Tokeshi, Y. Baba, Observation of ethanol-induced condensation and decondensation processes at a single DNA molecular level in microfluidic devices equipped with a rapid solution exchange system, Analytical Chemistry, 92, 9132-9137 (2020) DOI:10.1021/acs.analchem.0c01417

3. T. Suzuki, N. Kaji, H. Yasaki, T. Yasui, Y. Baba,  Mechanical low-pass filtering of cells for detection of circulating tumor cells in whole blood, Analytical Chemistry,  92, 2483-2491 (2020) DOI:10.1021/acs.analchem.9b03939

4. N. Yogo, T. Hase, T. Kasama, K. Nishiyama, N. Ozawa, T. Hatta, H. Shibata, M. Sato, K. Komeda, N. Kawabe, K. Matsuoka, T. F. Chen-Yoshikawa, N. Kaji, M. Tokeshi, Y. Baba, Y. Hasegawa, Development of an immuno-wall device for the rapid and sensitive detection of egfr mutations in tumor tissues resected from lung cancer patients, PloS One, 15, e0241422 (2020) DOI: 10.1371/journal.pone.0241422

5. 三浦夏琳, 井手幸子, 内藤豊裕, 嶋田泰佑, 安井隆雄, 馬場嘉信, 加地範匡, 九州大学伊都キャンパスにおけるPM2.5の生物学的観点からの実態調査・分析, 分析化学, 12, 741-746 (2020) DOI: 10.2116/bunsekikagaku.69.741

1. M. Terada, S. Ide, T. Naito, M. Matsusaki, N. Kaji, Evaluation of pluripotency in human intestinal cells by microfluidic-based single cell deformability analysis, The proceedings of μTAS 2020, Online, 1049-1050 (2020)

1. 加地範匡, マイクロ流体デバイスによる単一細菌・単一細胞の電気的センシング技術, 応用物理学会 有機分子・バイオエレクトロニクス分科会 (Molecular Electronics and Bioelectronics) 会誌, 31, 243-248 (2020) ISSN: 2423-8805

1. M. Sano, N. Kaji, A. C. Rowat, H. Yasaki, L. Shao, H. Odaka, T. Yasui, T. Higashiyama, Y. Baba,  Microfluidic mechanotyping of a single cell with two consecutive constrictions of different sizes and an electrical detection system, Analytical Chemistry, 91, 12890-12899 (2019) - This paper was selected as a supplementary journal cover picture of Analytical Chemistry. DOI:10.1021/acs.analchem.9b02818

2. Y. Hattori, T. Shimada, T. Yasui, N. Kaji, Y. Baba, Micro- and nanopillar chips for continuous separation of extracellular vesicles, Analytical Chemistry, 91, 6514-6521 (2019) DOI:10.1021/acs.analchem.8b05538

3. T. Yasui, T. Yanagida, T. Shimada, K. Otsuka, M. Takeuchi, K. Nagashima, S. Rahong, T. Naito, D. Takeshita, A. Yonese, R. Magofuku, Z. Zhu, N. Kaji, M. Kanai, T. Kawai, Y. Baba, Engineering nanowire-mediated cell lysis for microbial cell identification, Acs Nano, 13, 2262-2273 (2019) DOI: 10.1021/acsnano.8b08959

4. K. Nishiyama, K. Sugiura, N. Kaji, M. Tokeshi, Y. Baba, Development of a microdevice for facile analysis of theophylline in whole blood by a cloned enzyme donor immunoassay, Lab on a Chip, 19, 233-240 (2019) - This paper was selected as a back cover picture of Lab on a Chip. DOI:10.1039/c8lc01105b

5. M. F. Serag, A. Aikeremu, R. Tsukamoto, H. Piwonski, M. Abadi, N. Kaji, J. R. Dwyer, Y. Baba, S. Habuchi, Geometry-based self-assembly of histone-DNA nanostructures at single-nucleotide resolution, Acs Nano, 13, 8155-8168 (2019) DOI: 10.1021/acsnano.9b03259 

Refereed Conference proceedings

1. H. Takahashi, T. Yasui, K. Shinjo, N. Kaji, A. Okamoto, Y. Baba, Microheater-nanowires device for detection of cell-free circulating methylated DNA, The proceedings of μTAS 2019, Basel, 1886-1887 (2019)

1. A. M. Zeid, N. Kaji, J. J. M. Nasr, F. Belal, M. I. Walash, Y. Baba, Determination of baclofen and vigabatrin by microchip electrophoresis with fluorescence detection: Application of field-enhanced sample stacking and dynamic ph junction, New Journal of Chemistry, 42, 9965-9974 (2018) DOI:10.1039/c8nj00829a

2. H. Yukawa, K. Suzuki, K. Aoki, T. Arimoto, T. Yasui, N. Kaji, T. Ishikawa, T. Ochiya, Y. Baba, Imaging of angiogenesis of human umbilical vein endothelial cells by uptake of exosomes secreted from hepatocellular carcinoma cells, Scientific Reports, 8 (2018) DOI:10.1038/s41598-018-24563-0

3. H. Yasaki, T. Yasui, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai, Y. Baba, Effect of channel geometry on ionic current signal of a bridge circuit based microfluidic channel, Chemistry Letters, 47, 350-353 (2018) DOI:10.1246/cl.171139

4. H. Yasaki, T. Yasui, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai, Y. Baba, A real-time simultaneous measurement on a microfluidic device for individual bacteria discrimination, Sensors and Actuators B-Chemical, 260, 746-752 (2018) DOI:10.1016/j.snb.2018.01.079

5. H. Yasaki, T. Shimada, T. Yasui, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai, Y. Baba, Robust ionic current sensor for bacterial cell size detection, Acs Sensors, 3, 574-579 (2018) DOI:10.1021/acssensors.8b00045

6. T. Shimada, T. Yasui, A. Yokoyama, T. Goda, M. Hara, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, Y. Miyahara, T. Kawai, Y. Baba, Biomolecular recognition on nanowire surfaces modified by the self-assembled monolayer, Lab on a Chip, 18, 3225-3229 (2018) DOI:10.1039/c8lc00438b

7. T. Shimada, H. Yasaki, T. Yasui, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai, Y. Baba, PM2.5 particle detection in a microfluidic device by using ionic current sensing, Analytical Sciences, 34, 1347-1349 (2018) DOI:10.2116/analsci.18C018

8. M. Sano, N. Kaji, Q. Wu, T. Naito, T. Yasui, M. Taniguchi, T. Kawai, Y. Baba, Quantitative evaluation of dielectric breakdown of silicon micro- and nanofluidic devices for electrophoretic transport of a single DNA molecule, Micromachines, 9 (2018) DOI:10.3390/mi9040180

9. S. Zaitsu, T. Tanabe, K. Oshima, H. Hirata, Theoretical analysis of a molecular optical modulator for a continuous-wave laser based on a hollow-core photonic crystal fiber, Applied Sciences, 8, 1895 (2018)

10. S. Zaitsu, T. Tsuchiya, A molecularly modulated mode-locked laser, Scientific Reports, 8, 12175 (2018)

Refereed Conference proceedings

1. T. Suzuki, N. Kaji, H. Yasaki, T. Yasui, Y. Baba, Cell deformability measurement device for labeled-free cancer cells discriminating using ionic current detection, The proceedings of μTAS 2018, Kaohsiung, 347-348 (2018) selected as an oral presentation

2. T. Shimada, H. Yasaki, T. Yasui, A. Hibara, T. Yanagida, N. Kaji, M. Kanai, K. Nagashima, T. Kawai, Y. Baba, Pm2.5 analysis in liquid phase via water film-based collection and microfluidics-based electrical detection, The proceedings of μTAS 2018, Kaohsiung, 270-271 (2018) selected as an oral presentation

1. K. Iijima, N. Kaji, M. Tokeshi, Y. Baba, Micro- and nanochamber array system for single enzyme assays, Scientific Reports, 13, 13322 (2023) DOI: https://doi.org/10.1038/s41598-023-40544-4

2. Y. Kishimoto, S. Ide, T. Naito, Y. Nakashima, Y. Nakanishi, N. Kaji, Development of a microfluidic ion current measurement system for a single microplastic detection, Journal of Robotics and Mechatronics, 35, 1193 (2023) DOI: 10.20965/jrm.2023.p1193

3. Y. Banno, T. Nomiyama, S. Okuno, S. Ide, N. Kaji, Quantitative Evaluation of Interleukin-4 by Immunowall Devices Made of Gelatin Methacryloyl Hydrogel, Molecules, 28, 4635 (2023) DOI: 10.3390/molecules28124635

4. Y. Onizuka, K. Fujita, S. Ide, T. Naito, N. Kaji, Antioxidants encapsulated milk-derived exosomes for functional food development, Analytical Sciences, 39, 705-712 (2023), DOI: 10.1007/s44211-023-00278-9