Research

Skin and mucosal surfaces are the areas where various pathogens and antigens first encounter. Immune systems in these tissues play important roles in controlling various diseases including infection, allergy, autoimmune disease, and even cancer. We study how immune systems in the skin and mucosal tissues modulate disease pathogenesis and how to use immune systems to develop therapeutic strategies for incurable diseases.

B cells and antibody responses are one of the important arms of adaptive immunity. While tissue-resident memory T cells (TRMs) have been thoroughly studied in many different tissues, it is not well known about memory B cells resident in the peripheral tissue (BRMs). We focus on dissecting the mechanism of BRMs establishment, the roles of BRMs in controlling inflammation and homeostasis, and tissue-specific factors determining the establishment and function of BRMs.

We are pursuing continuous interaction and enrichment between basic research and clinical practice, translating scientific discoveries into new treatments that improve patient health.