Publications

Selected publications

1. LG Jang*, JW Huh*, et al. Mouth-to-gut microbial transmission signatures enable robust, non-invasive diagnosis of gastrointestinal cancers. Cell Host & Microbe. 2026 Aug 20; doi.org/10.1016/j.chom.2026.07.007 (*Co-first; IF = 23.2, 98.5% in Microbiology; 한빛사 논문)

   • • This study performed paired oral–fecal microbiome analysis in healthy individuals and patients with gastrointestinal (GI) cancers, complemented by extensive meta-analysis to chracterize generalizable oral-to-gut microbial  dynamics. 

     • GI cancer patients showed impaired decoupling between the oral and gut microbiomes, and ectopic transmission of oral bacteria was demonstrated to be a robust predictor of the GI cancers.

     • Cell Host & Microbe featured our study with an accompanying commentary: "Swallowing the evidence: Oral microbes mark gut cancer" Cell Host & Microbe. 2026 (https://doi.org/10.1016/j.chom.2026.08.013)

2. JW Huh, et al Enterotypical Prevotella and three novel bacterial biomarkers in preoperative stool predict the clinical outcome of colorectal cancer. Microbiome. 2022 Nov 28;10(1):203. doi: 10.1186/s40168-022-01388-8. (IF = 15.5, 96.5% in Microbiology; 한빛사 논문) 

• This paper revealed that the gut microbiota can predict the medical outcomes of colorectal cancer patients

• Fiber-digesting genus of Prevotella may improve the health of CRC patients

3. KH Kim*, Y Chung*, JW Huh*, et al. Gut microbiota of the young ameliorates physical fitness of the aged in mice. Microbiome. 2022 Dec 26;10(1):238. doi: 10.1186/s40168-022-01386-w. (*Co-first; IF = 15.5, 96.5% in Microbiology; 한빛사 논문) 

• This paper demonstrated that the gut microbiome of the young donor can rejuvenate the aged phenotype of skin and muscle in mice

• This also identified a host gene that is regulated by the 'young' microbiome and affects the skin phenotype

4. JW Huh$, et al. Charge-dependent localization of Toll-like receptor 5 at the plasma membrane. Mol Cells. 2025 Nov;48(11):100275. doi: 10.1016/j.mocell.2025.100275. Epub 2025 Sep 5. ($Correspondence; IF = 8.2, 88.3% in Molecular Biology)

5. JW Huh and TY Roh. Opportunistic detection of Fusobacterium nucleatum as a marker for the early gut microbial dysbiosis. BMC Microbiol. 2020 Jul 13;20(1):208. doi: 10.1186/s12866-020-01887-4.  (IF = 5.4, 78.1% in Microbiology) 

• This paper suggested a novel method for identifying 'dysbiosis' in the early phase from a longitudinal perspective. (cited# 87)

6. JW Huh*, T Shibata*, et al. UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 5. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7072-7. doi: 10.1073/pnas.1322838111. Epub 2014 Apr 28. (*Co-first; IF = 9.5, 90.4% in Multidisciplinary Science; 한빛사 논문) 

Others

1. J Kim, JW Huh, et al. Acidic amino acid residues in the juxtamembrane region of the nucleotide-sensing TLRs are important for UNC93B1 binding and signaling. J Immunol. 2013 May 15;190(10):5287-95. doi: 10.4049/jimmunol.1202767. Epub 2013 Apr 12. (IF = 5.4, 83.7% in Immunology)

2. HS Song, S Park, JW Huh, et al. N-glycosylation of UNC93B1 at a Specific Asparagine Residue Is Required for TLR9 Signaling. Front Immunol. 2022 Jul 7;13:875083. doi: 10.3389/fimmu.2022.875083. (IF = 7.3, 78.6% in Immunology) 

3. W Kang, A Park, JW Huh, et al.G You, DJ Jung, M Song, HK Lee, YM Kim. Flagellin-Stimulated Production of Interferon-β Promotes Anti-Flagellin IgG2c and IgA Responses. Mol Cells. 2020 Mar 31;43(3):251-263. doi: 10.14348/molcells.2020.2300. (IF = 8.2, 88.3% in Molecular Biology) 

4. S Kim, H Nam, E Lee, JW Huh, et al. Ion concentration polarization-based multifunctional microfluidic device for analysis of intracellular components. Sens. Actuator B-Chem. 2022. Nov 371(15). doi: 10.1016/j.snb.2022.132576 (IF = 7.7, 96.0% in Analytical Chemistry)

5. C Park, SA Lee, JH Hong, Y Suh, SJ Park, BK Suh, Y Woo, J Choi, JW Huh, et al. Disrupted-in-schizophrenia 1 (DISC1) and Syntaphilin collaborate to modulate axonal mitochondrial anchoring. Mol Brain. 2016 Jul 2;9(1):69. doi: 10.1186/s13041-016-0250-2. (IF = 2.9)