LG Jang*, JW Huh*, S Kim, JY Lee, HS Hwang, J Yoon, HG Lee, TI Kim, YC Lee, SH Jee, JF Kim. Oral microbiome signatures of gut transmission enable robust, non-invasive classification of gastrointestinal cancers. Cell Host & Microbe. 2026. Pre-accepted (*Co-first; IF = 23.2, 98.5% in Microbiology)
This study performed paired oral–fecal microbiome analysis in healthy individuals and patients with gastrointestinal (GI) cancers, complemented by extensive meta-analysis to chracterize generalizable oral-to-gut microbial dynamics.
GI cancer patients showed impaired decoupling between the oral and gut microbiomes, and ectopic transmission of oral bacteria was demonstrated to be a robust predictor of the GI cancers.
JW Huh, MJ Kim, J Kim, HG Lee, SB Ryoo, JL Ku, SY Jeong, KJ Park, D Kim, JF Kim, JW Park. Enterotypical Prevotella and three novel bacterial biomarkers in preoperative stool predict the clinical outcome of colorectal cancer. Microbiome. 2022 Nov 28;10(1):203. doi: 10.1186/s40168-022-01388-8. (IF = 15.5, 96.5% in Microbiology)
This paper revealed that the gut microbiota can predict the medical outcomes of colorectal cancer patients
Fiber-digesting genus of Prevotella may improve the health of CRC patients
KH Kim*, Y Chung*, JW Huh*, DJ Park, Y Cho, Y Oh, H Jeong, J Yoon, JH Kang, HS Shin, HC Kim, SK Kwon, KY Seo, SH Oh , JK Seong, SJ Ha, KT Nam, JF Kim. Gut microbiota of the young ameliorates physical fitness of the aged in mice. Microbiome. 2022 Dec 26;10(1):238. doi: 10.1186/s40168-022-01386-w. (*Co-first; IF = 15.5, 96.5% in Microbiology)
This paper demonstrated that the gut microbiome of the young donor can rejuvenate the aged phenotype of skin and muscle in mice
This also identified a host gene that is regulated by the 'young' microbiome and affects the skin phenotype
JW Huh and TY Roh. Opportunistic detection of Fusobacterium nucleatum as a marker for the early gut microbial dysbiosis. BMC Microbiol. 2020 Jul 13;20(1):208. doi: 10.1186/s12866-020-01887-4. (IF = 5.4, 78.1% in Microbiology)
This paper suggested a novel method for identifying 'dysbiosis' in the early phase from a longitudinal perspective.
JW Huh*, T Shibata*, M Hwang, EH Kwon, MS Jang, R Fukui, A Kanno, DJ Jung, MH Jang, K Miyake, YM Kim. UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 5. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7072-7. doi: 10.1073/pnas.1322838111. Epub 2014 Apr 28. (*Co-first; IF = 9.5, 90.4% in Multidisciplinary Science)
JW Huh*, K Park, HS Song, S Kim, YM Kim*. Charge-dependent localization of Toll-like receptor 5 at the plasma membrane. Mol Cells. 2025 Nov;48(11):100275. doi: 10.1016/j.mocell.2025.100275. Epub 2025 Sep 5. (*Correspondence; IF = 8.2, 88.3% in Molecular Biology)
J Kim, JW Huh, M Hwang, EH Kwon, DJ Jung, MM Brinkmann, MH Jang, HL Ploegh, YM Kim. Acidic amino acid residues in the juxtamembrane region of the nucleotide-sensing TLRs are important for UNC93B1 binding and signaling. J Immunol. 2013 May 15;190(10):5287-95. doi: 10.4049/jimmunol.1202767. Epub 2013 Apr 12. (IF = 5.4, 83.7% in Immunology)
HS Song, S Park, JW Huh, YR Lee, DJ Jung, C Yang, SH Kim, HM Kim, YM Kim. N-glycosylation of UNC93B1 at a Specific Asparagine Residue Is Required for TLR9 Signaling. Front Immunol. 2022 Jul 7;13:875083. doi: 10.3389/fimmu.2022.875083. (IF = 7.3, 78.6% in Immunology)
W Kang, A Park, JW Huh, G You, DJ Jung, M Song, HK Lee, YM Kim. Flagellin-Stimulated Production of Interferon-β Promotes Anti-Flagellin IgG2c and IgA Responses. Mol Cells. 2020 Mar 31;43(3):251-263. doi: 10.14348/molcells.2020.2300. (IF = 8.2, 88.3% in Molecular Biology)
S Kim, H Nam, E Lee, JW Huh, YM Kim, H Jeon, G Lim. Ion concentration polarization-based multifunctional microfluidic device for analysis of intracellular components. Sens. Actuator B-Chem. 2022. Nov 371(15). doi: 10.1016/j.snb.2022.132576 (IF = 7.7, 96.0% in Analytical Chemistry)
C Park, SA Lee, JH Hong, Y Suh, SJ Park, BK Suh, Y Woo, J Choi, JW Huh, YM Kim, SK Park. Disrupted-in-schizophrenia 1 (DISC1) and Syntaphilin collaborate to modulate axonal mitochondrial anchoring. Mol Brain. 2016 Jul 2;9(1):69. doi: 10.1186/s13041-016-0250-2. (IF = 2.9)