"Data, DiSCOVERY, DEPLOYMENT"

Preface

The microbiota in our bodies far outnumber our own cells, and their collective genetic diversity is estimated to be at least 2,000 times greater than our genes—highlighting the vast physiological potential of these 'micro-mates.' With the advances in next-generation sequencing (NGS) technologies, we now have unprecedented access to the hidden world of microbial communities.

For instance, research has increasingly linked the microbiota to the onset, progression, and even treatment of several cancers, conditions once solely attributed to genetic factors. A particularly intriguing aspect is the abnormal migration of oral microbes to distant organs, such as the colon, nasal passages, or genital tract, which can spark chronic inflammation and exacerbate seemingly mild diseases. This discovery suggests that the oral microbiota could serve as a non-invasive, highly informative diagnostic tool—offering an appealing alternative to traditional biopsies.

At our laboratory, we aim to:

1. Identify disease- (or health-) associated microbes through data-driven approaches.

2. Uncover the functions and roles of microbial genes and pathways involved in pathogenesis.

3. Ultimately, harness this knowledge for medical applications.

Our work aspires to turn the complexity of the microbiome into actionable insights that could revolutionize diagnostics and therapeutics, with your 'micro-mates' playing an essential role in shaping human health.