Contact Information
Li Juntao
Address: Address: Parexel International Singapore
51 Bras Basah Rd, Lazada One, 189554
E-mail: li.juntao at outlook.com
Interests: Biostatistics, Bioinformatics, Computational biology.
Education
2012 PhD in Statistics
Department of Statistics and Applied Probability, Faculty of Science, National University of Singapore, Singapore
2004 Master of Science in Applied Mathematics
Department of Mathematics, Beijing Normal University, Beijing, China
2001 Bachelor of Science in Statistics (Minor in Computer Science)
Department of Mathematics, Beijing Normal University, Beijing, China
Work Experience
Sep 2020 - Present Functional Services Provider (FSP), Parexel International Singapore
Feb 2022 - Present Manager, Biostatistics
Sep 2020 - Feb 2022 Principal Biostatistician
Feb 2016 - Sep 2020 Biometric and Medical Writing, Drug Development Satellite, Lundbeck Singapore.
Aug 2018 - Nov 2019 Senior Bioinformatician
Feb 2016 - Sep 2020 Biostatistician
Jun 2014 - Feb 2016 Biostatistician, SingHealth, Singapore
Apr 2004 - Jun 2014 Computational and Systems Biology, Genome Institute of Singapore, Singapore
Jun 2012 - Jun 2014 Postdoctoral Research Fellow
Apr 2006 - June 2012 Bioinformatics Specialist
Apr 2004 - Apr 2006 Research Assistant
Sep 2003 - Dec 2003 Intern Researcher
Statistical Computing Group, Intel China Research Center, Beijing, China
Jun 2002 - Sep 2002 Intern Researcher
Department of Bioinformatics, Beijing Genomics Institute, Beijing, China
Honors
- SingHealth Talent Development Funding Fellowship, Singapore, 2015
- Merck Millipore Young Scientist Award Singapore (MMYSA) 2011
- GIS Long Service Award 2010 in Genome Institute of Singapore
- Scientific Staff Development Award 2007 in Genome Institute of Singapore
- Monitor of Grade 2001, President of Postgraduate Student Union in postgraduate period, BNU
- The First Prize in China College Mathematical Contest in Modeling on September 2000
- Secretary of Training Department and Vice Secretary of Tutor Department, college PartTime Job Agency, BNU
- Specialty Scholarship, Outstanding Student Leader Award, Contest Scholarship in undergraduate period, BNU
- Monitor of class 972, Vice Secretary of Studying Department of Student Union in undergraduate period, BNU
Skills
- Language C/C++, python, perl
- R,SAS
- Mysql, Oracle, Linux, Office, LaTex
- Bioperl, BioEdit, GeneSpring
- Other softwares in Mathematics, Statistics and Bioinformatics
Note: one of the authors in Chinese translation of "R for Beginners"
Publications and Research Papers
Journal papers
- Valerie Chew, Liyun Lai, Lu Pan, Chun Jye Lim, Juntao Li, Raymond Ong, Camillus Chua, Jing Yao Leong, Kiat Hon Lim, Han Chong Toh, Ser Yee Lee, Chung Yip Chan, Brian Goh, Alexander Chung, Pierce Chow, and Salvatore Albani, Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses, PNAS, 2017. PubMed (IF: 9.661)
- Michelle Pek, Siti Yatim, Yufeng Chen, Juntao Li, Min Gong, Xia Jiang, Fan Zhang, Jie Zheng, Xiaojing Wu and Qiang Yu, Oncogenic KRAS-associated gene signature defines co-targeting of CDK4/6 and MEK as a viable therapeutic strategy in colorectal cancer, Oncogene, 2017. PubMed (IF: 7.519)
- Xia Jiang, Cheryl Zi Hui Lim, Zhimei Li, Puay Leng Lee, Siti Yatim, Peiyong Guan, Juntao Li, Jianbiao Zhou, Jingxuan Pan, Wee-Joo Chng, Christina L. L. Chai, and Qiang Yu, Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML), PLoS One. 10(4), 2015. PubMed (IF: 3.53)
- Liyun Lai, Raymond Ong, Juntao Li and Salvatore Albani, A CD45-based barcoding approach to multiplex mass-cytometry (CyTOF), Cytometry A. 2015. PubMed (IF: 3.066)
- Jianhua Liu, Yonghui Jia, Juntao Li, Zhaoqing Chu, Transcriptional profiling analysis of individual kinase-deletion strains of fission yeast in response to nitrogen starvation. Mol Genet Genomics. 2014 Dec 21.PubMed (IF: 2.831)
- Huaien Luo*, Juntao Li*, Burton Kuan Hui Chia, Paul Robson and Niranjan Nagarajan, The importance of study design for detecting differentially abundant features in high-throughput experiments, Genome Biology, 2014, 15:527. (*Equal contributors). PubMed (IF: 10.465)
- Min Feng, Yi Bao, Zhimei Li, Juntao Li, Min Gong, Stella Lam, Jinhua Wang, Diego M. Marzese, Nicholas Donovan, Ern Yu Tan, Dave S.B. Hoon and Qiang Yu, RASAL2 activates RAC1 to promote triple-negative breast cancer progression, The Journal of Clinical Investigation, 2014. PubMed (IF: 13.765)
- Shuet Theng Lee, Min Feng, Yong Wei, Zhimei Li, Yuanyuan Qiao, Peiyong Guan, Xia Jiang, Chew Hooi Wong, Kelly Huynh, Jinhua Wang, Juntao Li, K Murthy Karuturi, Ern Yu Tan, Dave S B Hoon, Yibin Kang, Qiang Yu, Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis. PNAS, 06/2013. PubMed (IF: 9.809)
-Jeena Gupta, Sandeep Kumar, Juntao Li, R Krishna M. Karuturi, Kulbhushan Tikoo, Histone H3 lysine 4 monomethylation (H3K4me1) and H3 lysine 9 monomethylation (H3K9me1): Distribution and their association in regulating gene expression under hyperglycaemic/hyperinsulinemic conditions in 3T3 cells, Biochimie, 2012. PubMed (IF: 3.142)
-Juntao Li, Puteri Paramita, Kwok Pui Choi and R Krishna M. Karuturi, ConReg-R: Extrapolative recalibration of the empirical distribution of p-values to improve false discovery rate estimates, Biology Direct, 6:27, 2011. PubMed; R code for ConReg-R (IF: 4.017)
-Juntao Li, Lei Zhu, Majid Eshaghi, Jianhua Liu and R Krishna M. Karuturi, Deciphering Transcription Factor Binding Patterns from Genome-wide High Density ChIP-chip Tiling Array Data, BMC Proceedings, 5(Suppl 2):S8, 2011. PubMed; EE
-Majid Eshaghi, Lei Zhu, Zhaoqing Chu, Juntao Li, Chee Seng Chan, Atif Shahab, R. Krishna M. Karuturi and Jianhua Liu, Deconvolution of ChIP-chip MBF occupancies reveals the temporal recruitment of Rep2 at the MBF-target genes, Eukaryotic Cell, Jan;10(1):130-41. 2011. PubMed (IF: 3.604)
-Majid Eshaghi, Jong Hoon Lee, Lei Zhu, Suk Yean Poon, Juntao Li, HyunKwang Cho, Zhaoqing Chu, R.Krishna M.Karuturi and Jianhua Liu, Genomic Binding Profiling of the Fission Yeast StressActivated MAPK Sty1 and the bZIP Transcriptional Activator Atf1 in Response to H2O2, PLoS ONE 5(7): e11620, 2010. PubMed (IF: 4.411)
-Huaien Luo, Juntao Li, Majid Eshaghi, Jianhua Liu and R.Krishna M.Karuturi, Genomewide estimation of firing efficiencies of origins of DNA replication from timecourse copy number variation data, BMC Bioinformatics, 11:247, 2010. PubMed; EE (IF: 3.028)
-Zhaoqing Chu, Juntao Li, R.Krishna M.Karuturi, Kui Lin and Jianhua Liu, Adaptive Expression Responses in the Polgamma Null Strain Depleted of Mitochondrial Genome in S-pombe, BMC Genomics, 8:323, 2007. PubMed (IF: 4.180)
-Majid Eshaghi, R.Krishna M.Karuturi, Juntao Li, Zhaoqing Chu, Edison T-Liu and Jianhua Liu, Global Profiling of DNA Replication Timing and Efficiency Reveals that Efficient Replication/ Firing Occurs Late During Sphase in Cells Released after HUblock in S-pombe, PLoS ONE 2(8): e722, 2007. PubMed (IF: 4.351)
-Zhaoqing Chu, Juntao Li, Majid Eshaghi, Xu Peng, R.Krishna M.Karuturi and Jianhua Liu, Modulation of Cell Cyclespecific Gene Expressions at the Onset of Sphase Arrest Contributes to the Robust DNA Replication Checkpoint Response in Fission Yeast, Mol Biol Cell, Vol-18, 17561767, 2007. PubMed (IF: 6.028)
-Juntao Li and Laifu Liu, Mathematical Model of Biosequence Alignment and It’s Applications, Mathematics in Practice and Theory (Chinese), Vol.35 No.1 P.511, 2005. Wan Fang
Conference full papers
-Juntao Li, Kwok Pui Choi and R Krishna M. Karuturi, Iterative Piecewise Linear Regression to Accurately Assess Statistical Significance in Batch Confounded Differential Expression Analysis, in the proc. of the 8th International Symposium on Bioinformatics Research and Applications (ISBRA 2012), University of Texas at Dallas, Dallas, Texas, USA, May 21-23, 2012. EE
-Juntao Li, Lei Zhu, Majid Eshaghi, Jianhua Liu, and R Krishna M.Karuturi, Deciphering Transcription Factor Binding Patterns from Genomewide High Density ChIPchip Tiling Array Data, in the proc-of the 6th International Symposium on Bioinformatics Research and Applications (ISBRA'10), University of Connecticut, Storrs, Connecticut, USA, May 23-26, 2010. EE
-Juntao Li, Fajrian Yunus, Lei Zhu, Majid Eshaghi, Jianhua Liu and R.Krishna M.Karuturi, Modeling and Visualizing Heterogeneity of Spatial Patterns of ProteinDNA Interaction from Highdensity Chromatin Precipitation Mapping Data, in the proc-of the 5th International Symposium on Bioinformatics Research and Applications (ISBRA'09),pp236-247, Ft-Lauderdale, Florida, USA, May 13-16, 2009. EE
-Juntao Li, Jianhua Liu and R.Krishna M.Karuturi, Statistical Significance Assessment in Batch Effect Confounded Differential Expression Analysis, in the proc-of The 1st International Workshop on Optimal Data Mining in Gene Expression Analysis (ODGEA'08),ISBRA'08,pp481491, 69 May, Atlanta, Georgia, USA, 2008. EE
-Juntao Li, Majid Eshaghi, Jianhua Liu and R.Krishna M.Karuturi, NearSigmoid Modeling to simultaneously profile Genomewide DNA replication timing and Efficiency in Single DNA replication microarray studies, in the proc-of The 6th Asia Pacific Bioinformatics Conference (APBC'08), pp383392,14-17 Jan, Kyoto, Japan, 2008. EE
-Juntao Li, Jianhua Liu and R.Krishna M.Karuturi, Datadriven Smoothness Enhanced Variance Ratio Test to Unearth Responsive Genes in Unreplicated 0time Normalized Timecourse Microarray Studies, Springer Verlag Lecture Notes in Bioinformatics series for ISBRA'07,pp2536, Atlanta, Georgia, USA, May 7-10, 2007. EE
-Qian Diao, Wei Hu, Hao Zhong, Juntao Li, Feng Xue, Tao Wang and Yimin Zhang, Disease Gene Explorer: Display Disease Gene Dependency by Combining Bayesian Networks with Clustering, in the proc-of the 2004 IEEE Computational Systems Bioinformatics Conference (CSB'04):574575, in Stanford, CA, 16-19 August, 2004. EE
Book chapter
-Juntao Li, , Kwok Pui Choi, Yudi Pawitan and R. Krishna M. Karuturi, Statistical Significance Assessment for Biological Feature Selection: Methods and Issues, in Biological Knowledge Discovery Handbook, Wiley, 2014. EE
Other papers
-Juntao Li, Statistical Significance Assessment in Computational Systems Biology, PhD dissertation, 2012. Download here.
-Juntao Li, Dynamic Bayesian Network Used in Protein Sequence Analysis, Master dissertation (Chinese), 2004.
-Juntao Li, Profile HMMs Protein Analysis Using PNL, Technical Report in Intel China Research Center, 2003.
-Juntao Li, Bioinformatics: the Core Science in the 21stcentury, Bachelor dissertation (Chinese), 2001.
-Juntao Li, Wenyan Song and Chunsheng Yao, DNA Sequence Analysis, the first prize paper in China College Mathematical Contest in Modeling (Chinese), 2000.
Academic Activities
- International Conference on Research in Computational Molecular Biology (RECOMB2017), Hong Kong, 3-7 May, 2017.
- 7th International Society forPharmacoeconomics and Outcomes Research (ISPOR) Asia-Pacific Conference, Singapore, 3-6 Sep, 2016.
- 15th Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS), San Diego, CA, USA, June 24-27, 2015.
-SingHealth Duke-NUS Scientific Congress 2014, Academia, Singapore, 5-6 Sep, 2014
-Joint Conference of HGM 2013 and 21st International Congress of Genetics, Marina Bay Sands, Singapore, 13-18 April, 2013
-2012 Merck Millipore Asia Bioforum, Matrix, Biopolis, Singapore, 19 Nov, 2012
-The 8th International Symposium on Bioinformatics Research and Applications (ISBRA 2012), University of Texas at Dallas, Dallas, Texas, USA, May 21-23, 2012.
-Second Singapore Conference on Statistical Science, National University of Singapore, Singapore, 19-20 Sep, 2011.
-Personalized Cancer Medicine:towards individualized cancer treatments, Matrix, Biopolis, Singapore, 21 – 23 Feb 2011.
-The 6th International Symposium on Bioinformatics Research and Applications (ISBRA’10), University of Connecticut, Storrs, Connecticut, USA, May 23-26, 2010.
-Statistical Genomics, Institute for Mathematical Sciences, National University of Singapore, Singapore, 1-28 July, 2009.
-The 5th International Symposium on Bioinformatics Research and Applications (ISBRA’09), Ft. Lauderdale, Florida, USA, 13-16 May, 2009.
-The 4th Mathematics and Physical Science Graduate Conference (MPSGC’08), Singapore, 17-19 Dec, 2008.
-Asia-Pacific Regional S.pombe Meeting 2008, Singapore, 25-27 July, 2008.
-The 7th World Congress in Probability and Statistics, Singapore, 14-19 July, 2008.
-The 12th Annual International Conference on Research in Computational Molecular Biology (RECOMB’08), National University of Singapore, Singapore, 30th Mar- 2nd Apr, 2008.
-The 6th Asia Pacific Bioinformatics Conference (APBC’08), Kyoto, Japan, 14-17 Jan, 2008.
-The 18th International Conference on Genome Informatics (GIW’07), Biopolis, Singapore, 3-4 Dec, 2007.
-AACR Centennial Conference on Translational Cancer Medicine: Technologies to Treatment. Singapore, 4-8 Nov, 2007.
-RECOMB Satellite Workshop on Regulatory Genomics, National University of Singapore, Singapore, 17-18 Jul, 2006.
-Workshop on BioAlgorithmics, Institute for Mathematical Sciences, National University of Singapore, Singapore, 12-14 Jul, 2006.
-The 5th HUGO Pacific Meeting and 6th Asia Pacific Conference on Human Genetics, Biopolis, Singapore, 17-20 Nov 2004.
-The first International Bioinformatics Workshop IBW 2003, Fudan University, Shanghai, China, 18-19 Dec, 2003.
-The Summer Course on Bioinformatics, Peking University, Beijing, China, July-Aug, 2001.
-The first China Bioinformatics Conference, Academy of Military Medical Sciences, Beijing, China, 11-13 May, 2001.