1. Development of anti-fibrotic agents for inflammatory bowel disease or other gastrointestinal disease
The central theme of my doctoral, postdoctoral, and professorial research has been the investigation of intestinal fibrosis associated with gastrointestinal diseases, particularly inflammatory bowel disease (IBD). My work has focused on elucidating the cellular and molecular mechanisms underlying fibrosis and on developing novel anti-fibrotic therapeutic agents targeting epithelial–mesenchymal transition and activated myofibroblasts.
2. Development of therapeutics using umbilical cord- or placenta-derived mesenchymal stem cells for gastrointestinal fibrosis
I have conducted research on the development of anti-fibrotic therapies targeting gastrointestinal fibrosis using mesenchymal stem cells derived from human umbilical cord or placenta tissues.
3. Therapeutic strategies for inflammatory bowel disease and other chronic, intractable enteritis
My work has focused on exploring novel treatment approaches for inflammatory bowel disease (IBD) and other forms of refractory chronic enteritis, with an emphasis on immune modulation and mucosal healing.
4. Identification of risk factors and development of diagnostic and therapeutic strategies for gastric and colorectal neoplasms
I have contributed to research identifying epidemiologic risk factors, as well as advancing diagnostic and therapeutic methods for gastric and colorectal tumors.
5. Epidemiological investigations of outbreaks of foodborne illness and infectious enteritis
I have participated in epidemiological studies investigating the causes and transmission patterns of foodborne disease outbreaks and various types of infectious enteritis, with the goal of informing public health interventions.
International journal (*major author)
Kang HN, Kim S, Lee SJ, Lee A, Lee SY, Go Y, Yoo JH, Park SM, Choi YJ, Hwang YH.
Prim-O-glucosylcimifugin attenuates intestinal fibrosis by modulating TGF-β/MAPK
signaling and ECM remodeling. Life Sci. 2025 Sep 5:123951.
Han YM, Yun SM, Lee DY, Song MY, Lee SW, Son WS, Yoo JH, Lim C, Kim SH, Kim
EH. Targeting KEAP1-mediated IKKβ degradation strategy for colitis-associated
colorectal carcinogenesis: The potential of xanthohumol. Biomed Pharmacother.
2025 Mar;184:117879.
Choi YJ, Kim JH, Lee Y, Pyeon HJ, Yoo IK, Yoo JH*. Anti-fibrogenic effect of
umbilical cord-derived mesenchymal stem cell-conditioned media in human
esophageal fibroblasts. Sci Rep. 2024 Sep 27;14(1):22233. (corresponding author)
Kim K, Park JJ, Yoon H, Lee J, Kim KO, Kim ES, Kim SY, Boo SJ, Jung Y, Yoo
JH, Hwang SW, Park SH, Yang SK, Ye BD; Scientific Committee of the Korean
Association for the Study of Intestinal Diseases. Application of clinical
decision support tools for predicting outcomes with vedolizumab therapy in
patients with inflammatory bowel disease: A KASID multicentre study. Aliment
Pharmacol Ther. 2024 Jun;59(12):1539-1550.
Choi YJ, Kim WR, Kim DH, Kim JH, Yoo JH*. Human umbilical cord/placenta
mesenchymal stem cell conditioned medium attenuates intestinal fibrosis in vivo
and in vitro. Stem Cell Res Ther. 2024 Mar 7;15(1):69. (corresponding author)
Lee KJ, Yon DK, Kim JH, Kim DH, Kim YS, Yoo JH*. Significance of
photodocumentation-associated factors in colonoscopy on the detection rate of
colorectal neoplasms. Eur Rev Med Pharmacol Sci. 2023 Apr;27(8):3552-3564. (corresponding author)
Kim JH, Oh CM, Yoo JH*. Obesity and novel management of inflammatory bowel
disease. World J Gastroenterol. 2023 Mar 28;29(12):1779-1794. (corresponding author)
Kim WH, Yoo JH, Yoo IK, Kwon CI, Hong SP. Effects of Mesenchymal Stem Cells
Treatment on Radiation-Induced Proctitis in Rats. Yonsei Med J. 2023
Mar;64(3):167-174.
Yoo JH*, Holubar S, Rieder F. Fibrostenotic strictures in Crohn's disease.
Intest Res. 2020 Oct;18(4):379-401. (corresponding author)
Choi YJ, Koo JB, Kim HY, Seo JW, Lee EJ, Kim WR, Cho JY, Hahm KB, Hong SP,
Kim DH, Yoo JH*. Umbilical cord/placenta-derived mesenchymal stem cells inhibit
fibrogenic activation in human intestinal myofibroblasts via inhibition of
myocardin-related transcription factor A. Stem Cell Res Ther. 2019 Sep
23;10(1):291. (corresponding author)
Yoo JH*, Donowitz M. Intestinal enteroids/organoids: A novel platform for drug
discovery in inflammatory bowel diseases. World J Gastroenterol. 2019 Aug
14;25(30):4125-4147. (corresponding author)
Kim GW, Kim YS, Lee SH, Park SG, Kim DH, Cho JY, Hahm KB, Hong SP, Yoo JH*.
Periodontitis is associated with an increased risk for proximal colorectal
neoplasms. Sci Rep. 2019 May 17;9(1):7528. (corresponding author)
Koo JB, Nam MO, Jung Y, Yoo J, Kim DH, Kim G, Shin SJ, Lee KM, Hahm KB, Kim
JW, Hong SP, Lee KJ, Yoo JH*. Anti-fibrogenic effect of PPAR-γ agonists in human
intestinal myofibroblasts. BMC Gastroenterol. 2017 Jun 7;17(1):73. (corresponding author)
Hahn S, Nam MO, Noh JH, Lee DH, Han HW, Kim DH, Hahm KB, Hong SP, Yoo JH*,
Yoo J. Organoid-based epithelial to mesenchymal transition (OEMT) model: from an
intestinal fibrosis perspective. Sci Rep. 2017 May 26;7(1):2435. (corresponding author)
Park JM, Lee HJ, Yoo JH, Ko WJ, Cho JY, Hahm KB. Overview of
gastrointestinal cancer prevention in Asia. Best Pract Res Clin Gastroenterol.
2015 Dec;29(6):855-67.
Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB. Dietary
prevention of Helicobacter pylori-associated gastric cancer with kimchi.
Oncotarget. 2015 Oct 6;6(30):29513-26.
Han YM, Park JM, Jeong M, Yoo JH, Kim WH, Shin SP, Ko WJ, Hahm KB. Dietary,
non-microbial intervention to prevent Helicobacter pylori-associated gastric
diseases. Ann Transl Med. 2015 Jun;3(9):122.
Yang MJ, Kim JH, Yoo BM, Hwang JC, Yoo JH, Lee KS, Kang JK, Kim SS, Lim SG,
Shin SJ, Cheong JY, Lee KM, Lee KJ, Cho SW. Partially covered versus uncovered
self-expandable nitinol stents with anti-migration properties for the palliation
of malignant distal biliary obstruction: A randomized controlled trial. Scand J
Gastroenterol. 2015;50(12):1490-9.
Yoo JH*, Ho S, Tran DH, Cheng M, Bakirtzi K, Kukota Y, Ichikawa R, Su B, Tran
DH, Hing TC, Chang I, Shih DQ, Issacson RE, Gallo RL, Fiocchi C, Pothoulakis C,
Koon HW. Anti-fibrogenic effects of the anti-microbial peptide cathelicidin in
murine colitis-associated fibrosis. Cell Mol Gastroenterol Hepatol. 2015
Jan;1(1):55-74.e1. (first author)
Cheng M, Ho S, Yoo JH*, Tran DH, Bakirtzi K, Su B, Tran DH, Kubota Y,
Ichikawa R, Koon HW. Cathelicidin suppresses colon cancer development by
inhibition of cancer associated fibroblasts. Clin Exp Gastroenterol. 2014 Dec
17;8:13-29. (co-first author)
Lee HS, An YS, Kang J, Yoo JH, Lee KJ. Effect of acute auditory stress on
gastric motor responses to a meal in healthy volunteers. J Gastroenterol
Hepatol. 2013 Nov;28(11):1699-704.
Lim SG, Lee KJ, Suh KW, Oh SY, Kim SS, Yoo JH, Wi JO. Preoperative
colonoscopy for detection of synchronous neoplasms after insertion of self-
expandable metal stents in occlusive colorectal cancer: comparison of covered
and uncovered stents. Gut Liver. 2013 May;7(3):311-6.
Koon HW, Shih DQ, Hing TC, Yoo JH, Ho S, Chen X, Kelly CP, Targan SR,
Pothoulakis C. Human monoclonal antibodies against Clostridium difficile toxins
A and B inhibit inflammatory and histologic responses to the toxins in human
colon and peripheral blood monocytes. Antimicrob Agents Chemother. 2013
Jul;57(7):3214-23.
Yu BH, Shin SJ, Lee KW, Ryoo KH, Wi JO, Yoo JH, Choi JW. A large polypoid
vascular ectasia removed by using a polypectomy with a detachable snare in an
asymptomatic patient. Ann Coloproctol. 2013 Feb;29(1):31-3.
Wi JO, Shin SJ, Yoo JH, Choi JW, Yoo BH, Lim SG, Lee KM, Kim JH. Insertion
of self expandable metal stent for malignant stomal obstruction in a patient
with advanced colon cancer. Clin Endosc. 2012 Nov;45(4):448-50.
Yoo JH*, Shin SJ, Lee KM, Choi JM, Wi JO, Kim DH, Lim SG, Hwang JC, Cheong
JY, Yoo BM, Lee KJ, Kim JH, Cho SW. How can we predict the presence of missed
synchronous lesions after endoscopic submucosal dissection for early gastric
cancers or gastric adenomas? J Clin Gastroenterol. 2013 Feb;47(2):e17-22. (first author)
Choi JM, Kim JH, Kim SS, Yu JH, Hwang JC, Yoo BM, Park SH, Kim HG, Lee DK,
Ko KH, Yoo KS, Park DH. A comparative study on the efficacy of covered metal
stent and plastic stent in unresectable malignant biliary obstruction. Clin
Endosc. 2012 Mar;45(1):78-83.
Yoo JH*, Shin SJ, Lee KM, Choi JM, Wi JO, Kim DH, Lim SG, Hwang JC, Cheong
JY, Yoo BM, Lee KJ, Kim JH, Cho SW. Risk factors for perforations associated
with endoscopic submucosal dissection in gastric lesions: emphasis on
perforation type. Surg Endosc. 2012 Sep;26(9):2456-64. (first author)
Yu JH*, Kim NY, Lee EJ, Jeon IS. Norovirus infections in asymptomatic food
handlers in elementary schools without norovirus outbreaks in some regions of
Incheon, Korea. J Korean Med Sci. 2011 Jun;26(6):734-9. (first author)
Yu JH*, Kim NY, Cho NG, Kim JH, Kang YA, Lee HG. Epidemiology of
Campylobacter jejuni outbreak in a middle school in Incheon, Korea. J Korean Med
Sci. 2010 Nov;25(11):1595-600. (corresponding author)
Yu JH*, Kim NY, Koh YJ, Lee HJ. Epidemiology of foodborne Norovirus outbreak
in Incheon, Korea. J Korean Med Sci. 2010 Aug;25(8):1128-33. (corresponding author)
Cheong JY, Cho SW, Yoo JH, Hong SP, Kim SO, Yoo WD, Kim JH. Selection of
precore mutants during lamivudine treatment in patients with chronic hepatitis
B. Hepatogastroenterology. 2008 May-Jun;55(84):1029-33.
Korean journal
Gil Soon Choi, Jun Hwan Yoo, Sung Jae Shin, Kee Myung Lee, Ki Baik Hahm, Jin Hong Kim and Jang Hee Kim: A case of acute hemorrhagic rectal ulcer syndrome. The Korean Journal of Internal Medicine 75(5): 577-581, 2008
Seung Hee Baik, Sung-Gyun Ahn, Jung-Hyun Choi, Bo Ram Koh, Jun Hwan Yoo, Soo-Jin Kang, Byoung-Joo Choi, So-Yeon Choi, Myeong-Ho Yoon, Seung-Jea Tahk and Joon-Han Shin: The Relationship of epicardial adipose tissue to metabolic syndrome and cardiovascular risk factors. The Korean Journal of Internal Medicine 72(3): 290-297, 2007
Hyoung Il Kim, Seung Hee Baik, Jun Hwan Yoo, Dai Yeol Joe, Jung Il Park, Hyun Woo Lee, Seok Yun Kang, Jun Ho Jang, Joon Seong Park, Jin Hyuk Choi and Hugh Chul Kim: Outcome of Severe Aplastic Anemia Treated with Immunosuppressive Therapy Compared with Bone Marrow Transplantation. The Korean Journal of Hematology 41(4): 259-265, 2006
Hyeok Choon Kwon, Kwang Jae Lee, Jang Hee Kim, Jun Hwan Yoo, Jae Myung Choi, Sung Jae Sin, Jae Yeon Chung, Ki Baik Hahm, Jin Hong Kim and Sung Won Cho: A Case of Barrett's Esophagus Developed 1 Year after Subtotal Gastrectomy due to Stomach Cancer. The Korean Journal of Neurogastroenterology and Motility 12: 77-80, 2006
Su Kyong Yu, Jae Myung Choi, Jun Hwan Yoo, Duck Kee Kim, Seung Jae Shin, Kee Myung Lee, Beung Moo Yoo, Ki Baik Hahm, Jin Hong Kim and Jae Ho Han: A Case of Intestinal Lymphangiectasia Improved with Antiplasmin and Octreotide Treatment. The Korean Journal of Gastrointestinal Endoscopy 33: 248-252, 2006
Jun Hwan Yoo*, In Ho Jung, Young Bae Kim, Jai Keun Kim, Ju Sung Sun, Seung Jun Choi, Joon Hyuck Choi, Kee Myung Lee, Ki Baik Hahm and Jin Hong Kim: A Case of Adult Intussusception of the Colon Caused by Cecal Neurofibroma in a patient with Neurofibromatosis Type 1. The Korean Journal of Gastrointestinal Endoscopy 31: 343-347, 2005 (first author)