🔷 Measurement of Brain Waste Clearance System (glymphatic, CSF, meningeal lymphatic vessels)

🔷 Deep Learning Applications on MRI

🔷  Development of novel MR Imaging Techniques and Sequence Programming

🔷 Simulation of MRI signal dynamics

🔵 Project Title: Development and Clinical Application of Novel MRI Techniques for Brain Waste Clearance and Brain Disease Diagnosis 

(Role: Principal Investigator, May 2024 - Current)

• Principal Investigator: Jun-Hee Kim; SNU

• Objective: This project aims to develop comprehensive imaging protocols and quantitative analysis techniques to visualize and assess the entire brain waste clearance pathway, including the glymphatic system, cerebrospinal fluid flow, and meningeal lymphatics. The goal is to apply these methods clinically to identify imaging biomarkers related to brain waste clearance activity, aiding in the early diagnosis and treatment of neurodegenerative and other brain diseases by finding indicators that influence disease progression.

⚫ Project Title: Basic Research Laboratory for Brain Cognitive Function based on Cerebrospinal Fluid Circulation 

(Role: Project Manager, June 2020 - February 2024)

• Principal Investigator: Sung-Hong Park; KAIST

• Objective: To develop novel quantitative MRI techniques for measuring cerebrospinal fluid circulation related to brain waste clearance, and to investigate the correlation between CSF circulation and factors such as brain diseases, sleep, and aging.

• Key Developments:

  1. Developed a novel inter-slice CSF-weighted MRI technique for measuring CSF circulation.

  2. Re-developed the proposed inter-slice CSF circulation measurement technique into a high-speed imaging method compatible with resting-state fMRI.

  3. Developed deep learning-based techniques for enhancing meningeal lymphatic vessel imaging and non-invasive methods for visualizing meningeal lymphatics.

  4. Confirmed changes in brain waste clearance activity related to brain diseases, Parkinson's disease, traumatic brain injury, and exercise using the proposed MRI techniques.

⚫ Project Title: Development of Simultaneous MRI-Optical Endoscopy for Brain Surgery 

(Role: Project Manager, February 2019 - March 2021)

• Principal Investigator: Sung-Hong Park; KAIST

• Objective: To develop a next-generation medical imaging device capable of simultaneous brain tumor diagnosis and treatment by establishing an MRI-optical endoscopy fusion system module optimized for brain tumor surgery.

• Key Developments:

  1. Developed an endoscope-attachable small MR coil for brain tumor surgery and improved image quality of the surgical site by developing associated MR image processing techniques.

  2. Developed a Graphical User Interface (GUI) for real-time simultaneous utilization of MRI/optical endoscopy images and endoscope position information.

  3. Established an MR-endoscopy real-time navigation system.

  4. Conducted certified testing and technology evaluation for the commercialization of the MR-endoscopy fusion system.