Three dimension (3D) nanofibrous scaffold/microparticles can be prepared using a thermally induced phase separation technique combined with particle leaching (TIPS&P). 

These scaffolds/microparticles feature well-defined microporous structures and collagen-like nanofibers, mimicking the physiological microenvironment, making them promising candidates for drug delivery and tissue regeneration. 

The stem cell secretome, has been recognized for its significant reparative abilities and is considered a promising alternative to traditional cell therapy. Controlled/sustained release of stem cells secretome from our bio-inspired scaffolds demonstrated the ability to enhance stem cell proliferation, migration, angiogenesis, and osteogenic differentiation, underscoring its significant potential for tissue regeneration.

Core-shell nanofibers as drug delivery vehicles show a lower burst release and sustained release of bioactive molecules. 

Nanoclay has demonstrated strong drug binding and sustained release capacity for many types of molecules.

Nanosized CaCO3/DNA coprecipitates were developed for gene delivery. 

Extracellular vesicles exhibit strong cell affinity and demonstrate significantly higher and safer drug delivery efficiency.